DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Ptp36E

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	372	Identity:	103/372 - (27%)
Similarity:	143/372 - (38%)	Gaps:	101/372 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 DEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYR-------KNPDLAITEARKPANAP 668
            ||..|.|..:....:..:..|.|.|      |..::.::|:       |........|.|..|..
  Fly    69 DENNSLSKTIPNGPIDIRHFLKLCD------LRRKFPVLYKLEFQTAAKVESNTCRHALKKNNLE 127

  Fly   669 KNRYRDISPYDCTRVSL--VNSL-TGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQ 730
            ||:.....|||..||.|  |..| ..||:||:||:..:   ..|.||.||||:..|...:||||.
  Fly   128 KNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLL---KPNAYIVTQGPVEETVQAYWRMVW 189

  Fly   731 QESSHLLVMLTTVMESGRQKCHQYWPVTGE--------------ELQLAEGFSVRCLSEKPDETG 781
            ||:...:||||...:..:..||||||...|              |.||| .|.:|
  Fly   190 QENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLA-NFHIR---------- 243

  Fly   782 SFVFREFVLKDKHE---QRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLK 843
              .||.:.:.:|.|   :|.|....|..|..|..|.. |..|||..|||......:
  Fly   244 --TFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGNII--------- 296

  Fly   844 QVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGV 908
                    .|.|:..|                                  |::||||.|.||:||
  Fly   297 --------KDEDDMRG----------------------------------PILVHCSDGGGRSGV 319

  Fly   909 LILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI 955
            .:.:|..|.|.|..|.......::.:|..|..:|:||.||:|:.:.:
  Fly   320 YMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528	91/308 (30%)
		PTPc	668..955	CDD:238006	90/306 (29%)
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	91/310 (29%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443568
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930