Protein Alignment Ptpmeg and IA-2

DIOPT Version :10

• Sequence 1: NP_612031.3
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Alignment Length: 1079
• Identity: 219/1079 - (20%)
• Similarity: 353/1079 - (32%)
• Gaps: 356/1079 - (32%)

  Fly    40 FLDDITHTFRIE-------------KRAKGSELLDQVFQYLELSERDYFGLLFPQ----KPGDVV 87
            |||  |...|||             :||:.:.|  :::|.|..||.|      ||    ||....
  Fly   369 FLD--TERQRIEREQQLAAAEQDADRRAEQNRL--ELYQILAASEPD------PQPYQRKPAAQP 423

  Fly    88 RWVD---------AQKQFKKQ-----------------CSSVSLDNDAVPLLEFRVKFFVSDPSR 126
            ..:|         .|::.|:|                 .|.:...::..|....|.:........
  Fly   424 NAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARGRSRGGLAEE 488

  Fly   127 LQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQT 191
            :::|..:..|:.::                           .|:...::..|.....::...|.|
  Fly   489 VEDEQPKRSFFREL---------------------------AGEQGLVQEPPLRFRHVETEVDAT 526

  Fly   192 TEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQH 256
            .|..::           .||.        .|:|:.|.:.|.:..                :.|:.
  Fly   527 PELVKR-----------RPAS--------FKQLDPYDVSLQQQE----------------MAFES 556

  Fly   257 SLRVNTFS----WSKMVKVSFKRKDFFIQLRRE------PSENYDT------------------L 293
            .|..|:.:    .:.:...||.|:....::..|      |.:..||                  :
  Fly   557 GLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANM 621

  Fly   294 LGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGR--TELQAVQESKQRG 356
            |||.                .|....:|:|..|       ||.....|..  .:|:..:..||:|
  Fly   622 LGFA----------------RHERLDVKKPGPL-------LGPPSLGSAELSNQLETEKAHKQKG 663

  Fly   357 RIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESA-----------------NSHNNGK 404
            ..:|..:.:..|     ......:........||||..:.|                 :|.|:|:
  Fly   664 HGNKEVLPAHIK-----GNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVHVFVKNPIDSWNDGQ 723

  Fly   405 -----------PAGAGTILTITK---TSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFI- 454
                       ..|..:.||:.:   :.|.:.|....|.|..:.|...|.:..:.:||..|||.
  Fly   724 RIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPERKTAGDVARTINENRGVKNNIQRRVGFYV 788

  Fly   455 ---------------EQCTRRFESASPSPMPP---AY---SSGQHSPILLPTTIADAVGHQQPES 498
                           ...:.|.|.|...|...   ||   .:|..:.|::..|:.....|.:
  Fly   789 LHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRHDR--- 850

  Fly   499 GSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVC--EGDEVLMINGRDV 561
                     :.|:.|.....:.|....|...|          :.|..|:.  .|.......|...
  Fly   851 ---------KRDKLGGLQSGIAGAETCSKDYQ----------ELCRARMAGKAGGGGNSTGGAAG 896

  Fly   562 HGLRHEQVVAMIRDCRHQASGELLLTVRP--QRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDA 624
            .|.........|.....:..|      ||  .||:.....|||..          ::.::..|..
  Fly   897 GGSNEPAPSGRITSLSKENEG------RPPSSRSSTSSWSEEPAL----------TNMDISTGHM 945

  Fly   625 LFTQSLLLLSDGLAS-GALLAQYELMYRKNPDLAITE-ARKPANAPKNRYRDISPYDCTRV---S 684
            :    |..:.|.|.: |.|..::|.:.|...:.:..| |.:|..|..||.....|||.:||   .
  Fly   946 V----LSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNH 1006

  Fly   685 LVNSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQ 749
            |.|:...||:||:.:....|....  |:|.||||.||...||:|:.::.:.::|.|..:.|:|..
  Fly  1007 LANAEGLDYVNASTITDHDPRAPA--YVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEV 1069

  Fly   750 KCHQYWPVTGEELQLAEGFSVRCLSEK--PDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDH 810
            .|.:|||..|.|:.  ..:.|..:||.  .|:   ::.|.|.||:  ..|.|.:....:|:||..
  Fly  1070 ACARYWPEEGAEVY--HIYEVHLVSEHIWCDD---YLVRSFYLKNLRTSETRTVTQFHFLSWPHM 1129

  Fly   811 CVPSDPNLFLEFTERV-RAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATP 874
            .||:.....|:|..:| ::.|.|                               |.|
  Fly  1130 GVPAQAKALLDFRRKVNKSYRGR-------------------------------RSC-------- 1155

  Fly   875 EDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALME--AREPVYPLDIVRT---M 934
                               |::||.|||.|||||.||:|..|..|.  |||    :||..|   :
  Fly  1156 -------------------PIVVHGSAGAGRTGVYILLDLVLERMNKGARE----IDIAATLEHL 1197

  Fly   935 RDQRACMVQNVSQYRFVCECICAAYMKISRSSAAINDDE 973
            |||||.:|....|:.||...:......|.::..|....|
  Fly  1198 RDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSGE 1236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_612031.3	B41	35..232	CDD:214604	38/234 (16%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	16/121 (13%)
		FA	333..369	CDD:462582	8/37 (22%)
		PDZ_PTPN3-4-like	500..589	CDD:467190	12/90 (13%)
		PTPc-N3_4	692..961	CDD:350389	79/278 (28%)
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	17/89 (19%)
		PTP_DSP_cys	942..1225	CDD:475123	100/355 (28%)