DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and AgaP_AGAP000292

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_566098.3	Gene:	AgaP_AGAP000292 / 3289648	VectorBaseID:	AGAP000292	Length:	866	Species:	Anopheles gambiae

Alignment Length:	517	Identity:	104/517 - (20%)
Similarity:	172/517 - (33%)	Gaps:	167/517 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 EHQPGYLSGMQLL-----------CDQTTEAERKVGELHKLHRGQLPADA----EYNYLE----- 219
            :..||.|..:||.           |||...:||...:       :||...    |..|:|
Mosquito    14 QQPPGALHNLQLKLPLHRTAIDAGCDQGYGSERSPED-------ELPPPLLLMHETQYIELLTAS 71

  Fly   220 -HAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKV---SFKRKD--F 278
             .|..|...|....:..|...::.|           |...:...::....|.|   ||..||  |
Mosquito    72 TAADCLGTAGPVQQQPGDGTQQQQQ-----------QQPYQPTYWTGGNQVVVGPYSFITKDSIF 125

  Fly   279 FIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR--PHRLSRFLNISLGSKFYYS 341
            |:|:.:....     |||.:|....:.|.:...:      |:||  ||:.:           :.:
Mosquito   126 FVQVAKGSRG-----LGFSVSGGSDSSAPYPGLI------RIKRLFPHQAA-----------WAT 168

  Fly   342 GRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPA 406
            |..:                    |...|| .|.||..:|.:              |.|...:..
Mosquito   169 GMLQ--------------------PGDILL-EANGVPLTGLT--------------NYHALEELR 198

  Fly   407 GAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPP 471
            .|..::|:| ..||.|.:.......:.|.:...:.:..|:            ....|...||:||
Mosquito   199 KATNVVTLT-VCRPKDEQYRKLSPPTEPPRPPLRNAPSYE------------HGSGSVPQSPLPP 250

  Fly   472 A---YSSGQHSPILLPTTIADAVGHQQPESGS-------------DLITIRLQAD-------EQG 513
            |   |...|..           :.|..|.:|:             |.|......:       :||
Mosquito   251 AGIPYPQQQQQ-----------LQHFFPPTGASWNQQVAGFLPPLDPIQTSFSGEFEIVMTKQQG 304

  Fly   514 RYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRH 578
            ..||.::...|..|...|..:| ..|| ....|:..||:::.:|...|..:.||:.|..:|
Mosquito   305 SLGFTLRKEDDSVLGHYVRALV-REPA-LSDGRIRPGDKIVAVNDVPVSSMTHEEAVIFLR---- 363

  Fly   579 QASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEI-GSHSNLLDGDALFTQSLLLLSDGLAS 639
            ||:..:.|.:...::      :.||..:.|....: |:.:.|:    |..::..||:|..||
Mosquito   364 QAADVVRLRLYRDQA------QTPLSAHSPSDASVRGARTRLI----LRPEARNLLNDLAAS 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	18/77 (23%)
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785	18/77 (23%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	18/98 (18%)
		FA	333..369	CDD:285894	2/35 (6%)
		PDZ_signaling	502..589	CDD:238492	23/93 (25%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
AgaP_AGAP000292	XP_566098.3	PDZ	124..212	CDD:214570	27/145 (19%)
		PDZ_signaling	294..373	CDD:238492	22/84 (26%)
		PDZ_signaling	728..807	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900