DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and gopc

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_956851.1	Gene:	gopc / 326887	ZFINID:	ZDB-GENE-030131-5086	Length:	455	Species:	Danio rerio

Alignment Length:	466	Identity:	85/466 - (18%)
Similarity:	156/466 - (33%)	Gaps:	152/466 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 SNGKELQLGVSAV---GLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLG--- 295
            |.|..|..|.:|.   |:.:|:         |.::::..|.:.  |:.:        |.|||
Zfish    10 SPGSGLSAGPAAATGSGMSMFR---------WLEVLEKEFDKA--FVDV--------DLLLGEID 55

  Fly   296 --------------FGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTEL 346
                          ..:||     ...:.|.:..:.|:|.  |:|...| :.|        |:||
Zfish    56 PDQADITYEGRQKMTSLSS-----CFAQLCHKAQTIFQLN--HKLEAQL-VDL--------RSEL 104

  Fly   347 QAVQESK--QRGRIHKVFVRSPSKRL-LGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGA 408
            ..||..|  ....:|:..::..:.:| |.|.||......|....|...|..|..      |...|
Zfish   105 TDVQAEKVVVEKEVHEQLLQLHAMQLKLQAKGGQAVDSDSIKDRMPVPSVEEKE------KELEA 163

  Fly   409 GTILTITKTSRPHDNKVTSKEADSMPR-------------------------------------- 435
            .....:.:.....:.|:..||.:::.|
Zfish   164 SKKEKVKEVKLEAEVKMLKKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMK 228

  Fly   436 -----KAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGH-- 493
                 |.|.|...|..:......|..|..|.:...|.|.|                    |||
Zfish   229 GPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDPKKPLPSP--------------------VGHDT 273

  Fly   494 ---QQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLM 555
               ::.:....:..:.|..::....|.::.||.:..:|:.:|::.|..||:|| ..:..||.:|.
Zfish   274 DSLKKTQGVGPIRKVVLTKEDHEGLGISITGGKEHGVPILISEIHPTQPAERC-GGLHVGDAILA 337

  Fly   556 INGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPES--------DE 612
            :|..::...:|::.|.::...|.:...|::..      ||.:..::...:|..:|        ||
Zfish   338 VNNINLRDAKHKEAVTILSQQRGEIEFEVVYV------APEVDSDDENVEYEDDSGHRYRLYLDE 396

  Fly   613 I-----GSHSN 618
            :     .:|:|
Zfish   397 LEEASAANHNN 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	18/102 (18%)
		FA	333..369	CDD:285894	8/37 (22%)
		PDZ_signaling	502..589	CDD:238492	19/86 (22%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
gopc	NP_956851.1	PDZ_signaling	285..367	CDD:238492	19/82 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910