DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and frmd6

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001018652.1	Gene:	frmd6 / 321937	ZFINID:	ZDB-GENE-050522-354	Length:	616	Species:	Danio rerio

Alignment Length:	491	Identity:	106/491 - (21%)
Similarity:	196/491 - (39%)	Gaps:	109/491 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWV 90
            :.|..|.::||.|...:|.|....:..:....|||.||...|.|.:...|||...|....:  ::
Zfish     8 NNKMMQDRRCVCVFLPNDETLNVIVSVKTVCQELLVQVCDLLRLKDCHLFGLSVIQNNEHI--YM 70

  Fly    91 DAQKQFKKQC-------SSVSLDNDAVPLL-EFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLG 147
            :..::..|.|       :|..:|....|:: .||.:::|.:...:.:...||.:|..:::.:|..
Zfish    71 ELGQKLSKHCPKEWKREASKGIDQFGPPMIVHFRAQYYVENGRLISDRVARYYYYWHLRKQVLQS 135

  Fly   148 KLPCSSNTQCLLASYTVQSELGDFNALEH-----QP-GYLSGMQLL---CDQTTEAERKVGELHK 203
            :.........|||::.:|::||:|...:|     || .|.....:.   ||...   |.:..:||
Zfish   136 QCIQREEAYFLLAAFALQADLGNFKRNKHFGAYFQPEAYFPSWVIAKRGCDYIL---RHIPNMHK 197

  Fly   204 LHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQ----LGVSAVGLLVFQHSLRVNT-- 262
            .......::|:..|::.|..|:...:..:|.. .:.|||.    ||::..|:.:||:   |.|
Zfish   198 EQFACTASEAQLKYIKEATLLDDVAVHYYRLY-KDKKELDASLTLGLTLRGIQIFQN---VGTVR 258

  Fly   263 -----FSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKAL--WKSCV--EHHSFF 318
                 |.|:.:.|:.|..|.|             .:|..|:.|   |:.|  :..|.  ..|...
Zfish   259 QLLYDFPWTNVGKLVFVGKRF-------------EILPDGLPS---ARKLIYYTGCPLRSRHLLQ 307

  Fly   319 RLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFV-------------RSPSKRL 370
            .|...|||  ::|:....|       :::.::|::::.:..:.::             ||.:
Zfish   308 LLSNSHRL--YMNLQPVLK-------QVRRLEENEEKKQYRESYIGDALEADMDHLEQRSRA--- 360

  Fly   371 LGAAGGVGTSGSSGGT-----PMQQHSGSESANSHNNGKPAGAGTILTITKTSRPH--------- 421
                     ||||.|:     |..:|    |..||.:.:.:|..|....|.|:.||
Zfish   361 ---------SGSSAGSTSRPNPFSRH----STTSHGSSRTSGVDTDSFRTPTNTPHRPLRTHSSS 412

  Fly   422 DNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQC 457
            :....|.....:...:.|...||.:|::.|...:.|
Zfish   413 NTSHASTHTSGIESSSKEHCLDEDEIEMLVDDPKSC 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	48/213 (23%)
		FERM_N	38..102	CDD:286467	16/70 (23%)
		FERM_M	125..232	CDD:278785	24/115 (21%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	24/108 (22%)
		FA	333..369	CDD:285894	4/48 (8%)
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
frmd6	NP_001018652.1	B41	20..215	CDD:214604	44/199 (22%)
		FERM_N	20..82	CDD:286467	16/63 (25%)
		FERM_M	115..226	CDD:278785	24/113 (21%)
		FERM_C_FRMD1_FRMD6	219..327	CDD:270006	30/136 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910