DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Ptp10D

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster

Alignment Length:	372	Identity:	113/372 - (30%)
Similarity:	158/372 - (42%)	Gaps:	97/372 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   591 QRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPD 655
            :::.|:|::            ....|..|:..|:.|..|              .::|.:.....|
  Fly  1247 EQNRPILIK------------NFAEHYRLMSADSDFRFS--------------EEFEELKHVGRD 1285

  Fly   656 LAITEARKPANAPKNRYRDISPYDCTRVSL--VNSLTG-DYINANYVNMEIPG-GAVNRYIATQG 716
            ...|.|..|.|.||||:.:|.|||.:|..|  |:...| ||||||||    || .:...:|.|||
  Fly  1286 QPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYV----PGHNSPREFIVTQG 1346

  Fly   717 PLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEG-FSVRCLSEKPDET 780
            ||.||..|||||..:.:|..:||||...|.||:||.||||  .:.:.:..| ..|:.|::  ...
  Fly  1347 PLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP--NDTVPVFYGDIKVQILND--SHY 1407

  Fly   781 GSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQV 845
            ..:|..||:|....|||.:.|..:..|||..||:.|...:.|   |||.|:|
  Fly  1408 ADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRF---VRAFRDR------------- 1456

  Fly   846 RLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLI 910
                                                      |.|...|::||||||:||:|..|
  Fly  1457 ------------------------------------------IGAEQRPIVVHCSAGVGRSGTFI 1479

  Fly   911 LMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA 957
            .:|..|..:...:.|....||..||.:|..|||...||..:.:|:.|
  Fly  1480 TLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA 1526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528	99/293 (34%)
		PTPc	668..955	CDD:238006	98/291 (34%)
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	106/332 (32%)
		PTPc	1298..1525	CDD:238006	99/292 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443515
Domainoid	1	1.000	133	1.000	Domainoid score	I1104
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840