DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Ptpmeg2

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	627	Identity:	154/627 - (24%)
Similarity:	230/627 - (36%)	Gaps:	200/627 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 LLGAAGGVGTSGSSGGTPMQQHSGSESANS----------HNNGK-------------PAGA--- 408
            ::|..||.|:..::|...:...:|:|:..:          |..|.             |||:
  Fly   341 IVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAGSASG 405

  Fly   409 GTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAY 473
            |.....:..:.|::| :|........|:|....|........|            |:|..:..:.
  Fly   406 GATTAASAATEPNEN-ITINGLSPSHRQAANNSSSSSSSAATV------------ANPLKLNTSG 457

  Fly   474 SSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHT 538
            |:..:|.|...||.|.|.|                    ...|....||         .:.....
  Fly   458 SADNNSTITNATTAAGAAG--------------------AAAGTTTNGG---------GEFWSEN 493

  Fly   539 PADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPL 603
            |....:....:.|.   :.|::......:|:|.|::                ||
  Fly   494 PPSSASSGFSDDDS---LAGQEGDPKPIDQIVQMVK----------------QR----------- 528

  Fly   604 YQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAP 668
                      |.|                        .|:.:|..:..:.|:.....||..||..
  Fly   529 ----------GRH------------------------GLIKEYADIRNRAPEGTFLHARMRANLT 559

  Fly   669 KNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEIPGG--AVNRYIATQGPLASTTTDFWRM 728
            ||||.|:..||.:||.|.:   ....||||||:|:     |  ..|.||:|||||..|:.|||||
  Fly   560 KNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVD-----GYKQKNAYISTQGPLPKTSQDFWRM 619

  Fly   729 VQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEG-FSVRCLSEKPDETGSFVFREFVLKD 792
            :.::...::||.|.|||.||.||.|||..| ||..|..| :.||.:|.:.:|  .::.....|::
  Fly   620 IWEQHCLVIVMTTRVMERGRVKCGQYWEPT-EESSLEFGDYHVRTISVECNE--DYMVASLELRN 681

  Fly   793 --KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADAD 855
              ..|.|::.|.|:.:|||:.|||.....|.|.::||.              ||.:|:....|
  Fly   682 IKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVRE--------------KQAQLVQGLGD-- 730

  Fly   856 ENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALME 920
                                     :.:.|    ...||::|||||||||||..|.:|..::.:
  Fly   731 -------------------------TWAGH----PRGPPIVVHCSAGIGRTGTFITLDICISRL- 765

  Fly   921 AREPVYPLDI---VRTMRDQRACMVQNVSQYRFVCECICAAY 959
              |.|...||   |..:|.|||..:|...||.| |......|
  Fly   766 --EDVGTADIRGTVEKIRSQRAYSIQMPDQYVF-CHLALIEY 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	9/86 (10%)
		Y_phosphatase	666..955	CDD:278528	104/299 (35%)
		PTPc	668..955	CDD:238006	103/297 (35%)
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099
		Y_phosphatase	557..803	CDD:278528	104/302 (34%)
		PTPc	559..803	CDD:238006	103/300 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443555
Domainoid	1	1.000	133	1.000	Domainoid score	I1104
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930