DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Rdx

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_038937380.1	Gene:	Rdx / 315655	RGDID:	1359472	Length:	604	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	138/573 - (24%)
Similarity:	231/573 - (40%)	Gaps:	126/573 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 FRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPL 112
            |.|:....|.:|.|||.:.:.|.|..:|||.:....| ...|:...|:..:|  .|..:|   ||
  Rat    18 FAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKG-YSTWLKLNKKVTQQ--DVKKEN---PL 76

  Fly   113 -LEFRVKFFVSDPS-RLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALE 175
             .:||.|||..|.| .|.:|.|:..|:||:|..||..::.|...|..|||||.||::.||:|...
  Rat    77 QFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEI 141

  Fly   176 HQPGYLSGMQLLCDQTTEA--------ERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLH 232
            |:||||:..:||..:..|.        |.::...|:.|||.|..|:...||:.|:.||:||::..
  Rat   142 HKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYF 206

  Fly   233 RATDSNGKELQLGVSAVGLLVFQHSLRVNT---FSWSKMVKVSFKRKDFFIQLRREPSENY---- 290
            ...:..|.||.|||.|:||.:::|..::..   |.||::..:||..|.|.|:...:.:.::
  Rat   207 EIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYA 271

  Fly   291 ------DTLLGFGMSSH------------------------KHAKALWKSCVEHH---------S 316
                  ..:|...|.:|                        ||.|.|.::.:|:.         .
  Rat   272 PRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKE 336

  Fly   317 FFRLKRP-----HRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGG 376
            ..|::|.     .||.:....::.::.....:|. :|::..::|.|..:...|...:|
  Rat   337 KERIEREKEELMERLRQIEEQTMKAQKELEEQTR-KALELEQERQRAKEEAERLDRER------- 393

  Fly   377 VGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHD-NKVTSKEADSMPRKAWEQ 440
                  ......:.....::|:...|.:...|.......|.:...: .|...:||.....||:..
  Rat   394 ------RAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAA 452

  Fly   441 QSDEYDIQLDVGFIEQCTRRFES---ASPSPMPPAY---------SSGQHSPILLPTTIADAVGH 493
            |.|          :|:.....::   |.|.|.|||.         ...:||........::.|.:
  Rat   453 QED----------LEKTKEELKTVMCAPPPPPPPAVVPPTENEHDEQDEHSAEASAELSSEGVTN 507

  Fly   494 QQPE-------SGSDLITIRLQA---------DEQGR------YGFNVKGGVD 524
            .:.|       ..::.:..:|||         ||..:      :..|||.|.|
  Rat   508 HRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRD 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	70/193 (36%)
		FERM_N	38..102	CDD:286467	16/53 (30%)
		FERM_M	125..232	CDD:278785	44/115 (38%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	28/139 (20%)
		FA	333..369	CDD:285894	5/35 (14%)
		PDZ_signaling	502..589	CDD:238492	10/38 (26%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
Rdx	XP_038937380.1	B41	7..206	CDD:214604	70/193 (36%)
		FERM_C_ERM	200..296	CDD:270015	23/95 (24%)
		ERM	347..583	CDD:395622	40/238 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910