DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Ptprd

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_038967340.1	Gene:	Ptprd / 313278	RGDID:	1561090	Length:	1940	Species:	Rattus norvegicus

Alignment Length:	959	Identity:	219/959 - (22%)
Similarity:	346/959 - (36%)	Gaps:	294/959 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 VPLLEFRVKFFV--SDPSRLQ-----EEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSE 167
            |||.:.|.||..  ..|..::     :|.:|.:..::..|.:.| |...:::...|...:|
  Rat  1154 VPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVEL-KPYIAAHFDVLPTEFT---- 1213

  Fly   168 LGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEYNY-----LEHAKRLELY 227
            |||.   :|..|:.:                        .||.:..||.:     ::||:. ::|
  Rat  1214 LGDD---KHYGGFTN------------------------KQLQSGQEYVFFVLAVMDHAES-KMY 1250

  Fly   228 ----------GIDLHRATDSNGKELQLGV------------SAVGLLVFQHS----------LRV 260
                      .:||.....::.:|..:.|            ..:.:|:::.|          .|.
  Rat  1251 ATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSSKPDRKRAESESRK 1315

  Fly   261 NTFSWSKMV-------KVSFKRKDFFIQLRREPSENYDTLLGF-GMSSHKHAKALWKSCVEHHSF 317
            ::...||.|       .|..:|.:|  |........|...|.| .|:||.....|  ...:|  .
  Rat  1316 SSLPNSKEVPSHHPTDPVELRRLNF--QTPGSDDSGYPGNLHFSSMASHPPIPIL--ELADH--I 1374

  Fly   318 FRLKRPHRL---SRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGT 379
            .|||....|   ..:.:|..|.:|.:    |...::.:|.:.|...|.....|:.||.|..|:
  Rat  1375 ERLKANDNLKFSQEYESIDPGQQFTW----EHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGI-- 1433

  Fly   380 SGSSGGTPMQQHSGSESANSH-------NNGKPAGAGTILTITKTSRPHDNKVTSKEADSMP--- 434
                        .||:..|::       .|...|..|                      |:|
  Rat  1434 ------------PGSDYVNANYIDGYRKQNAYIATQG----------------------SLPETF 1464

  Fly   435 ----RKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQ 495
                |..|||:|      ..|..:.:...|.........|   |.|..:..|:..|:.|.|
  Rat  1465 GDFWRMIWEQRS------ATVVMMTKLEERSRVKCDQYWP---SRGTETHGLVQVTLLDTV---- 1516

  Fly   496 PESGSDLITIRLQADEQGRYGFNVKGGV---------DLSLPVQ-------VSKVVPHTPAD--- 541
                 :|.|..::.....:.|.:.|..|         |..:|..       :.:|....|.|
  Rat  1517 -----ELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGP 1576

  Fly   542 ---RCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPL 603
               .|:..|......::|:.. :..::||:.|.:.        |.:.| :|.||:  .:::.|..
  Rat  1577 MVVHCSAGVGRTGCFIVIDAM-LERIKHEKTVDIY--------GHVTL-MRAQRN--YMVQTEDQ 1629

  Fly   604 YQYVPESDEIGSHSNLLD----GDA--------LFTQSLLLLSDG-LASGALLAQYELMYRKNPD 655
            |.::        |..||:    |:.        .:.|.|..:..| ..:|..|....|...|...
  Rat  1630 YIFI--------HDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHT 1686

  Fly   656 LAITEARKPANAPKNRYRDISPYDCTRVSL--VNSLTG-DYINANYVNMEIPGGAVNR-YIATQG 716
            .....|..|.|..|||..:|.||:.|||.|  :..:.| |||||::::    |....: ||||||
  Rat  1687 SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFLD----GYRQQKAYIATQG 1747

  Fly   717 PLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETG 781
            |||.||.|||||:.:.:|.::||||.:.|.||:|||||||  .|.....:.|.|..::|.  ...
  Rat  1748 PLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP--AERSARYQYFVVDPMAEY--NMP 1808

  Fly   782 SFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQ 844
            .::.|||.:.|..  :.|.:...|:..||:..||.....|::|..:|         .:.:|...|
  Rat  1809 QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV---------HKTKEQFGQ 1864

  Fly   845 VRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVL 909
                                                           :.|:.||||||:|||||.
  Rat  1865 -----------------------------------------------DGPISVHCSAGVGRTGVF 1882

  Fly   910 ILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA 958
            |.:...|..|.....|.....|:.:|.||..|||...||:|   |..||
  Rat  1883 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQF---CYRAA 1928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	27/143 (19%)
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785	20/126 (16%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	23/133 (17%)
		FA	333..369	CDD:285894	7/35 (20%)
		PDZ_signaling	502..589	CDD:238492	18/108 (17%)
		Y_phosphatase	666..955	CDD:278528	94/294 (32%)
		PTPc	668..955	CDD:238006	93/292 (32%)
Ptprd	XP_038967340.1	I-set	31..123	CDD:400151
		Ig strand A'	39..43	CDD:409353
		Ig strand B	46..55	CDD:409353
		Ig strand C	61..66	CDD:409353
		Ig strand C'	69..72	CDD:409353
		Ig strand D	75..83	CDD:409353
		Ig strand E	84..94	CDD:409353
		Ig strand F	102..110	CDD:409353
		Ig strand G	113..123	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	135..234	CDD:409400
		Ig strand B	151..155	CDD:409400
		Ig strand C	164..168	CDD:409400
		Ig strand E	198..202	CDD:409400
		Ig strand F	212..217	CDD:409400
		Ig strand G	224..227	CDD:409400
		IgI_3_RPTP_IIa_LAR_like	247..328	CDD:409401
		Ig strand B	261..265	CDD:409401
		Ig strand C	274..278	CDD:409401
		Ig strand E	295..299	CDD:409401
		Ig strand F	307..312	CDD:409401
		Ig strand G	320..323	CDD:409401
		FN3	331..420	CDD:238020
		FN3	427..519	CDD:238020
		FN3	524..612	CDD:238020
		FN3	620..714	CDD:238020
		fn3	721..820	CDD:394996
		FN3	832..927	CDD:238020
		FN3	930..1021	CDD:238020
		FN3	1031..>1092	CDD:238020
		R-PTPc-D-1	1362..1645	CDD:350472	67/364 (18%)
		R-PTP-D-2	1646..1937	CDD:350476	106/350 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910