DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Epb41l4a

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_006254645.1	Gene:	Epb41l4a / 307514	RGDID:	1306034	Length:	688	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	166/488 - (34%)
Similarity:	244/488 - (50%)	Gaps:	61/488 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PQRQQCVTVLFLDD--ITHTFR---IEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRW 89
            |:...| .||.||:  :|.|.:   |:|..|||.:||.||:::.|.|.|||||.:..:..... |
  Rat     8 PEEFYC-EVLLLDESKLTLTTQHQGIKKSTKGSVVLDHVFRHVNLVEIDYFGLRYCDRSHQTY-W 70

  Fly    90 VDAQKQFKKQCSSVSLDNDAVP-LLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSS 153
            :|..|...:.   ..|.|...| .|.|.:||:..||.:|:||.|||||:||:|::.|.|:|||..
  Rat    71 LDPAKTLAEH---KELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDALQGRLPCPV 132

  Fly   154 NTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEYNYL 218
            |....|.:|.:|:||||.:..:|..||:|..:.:.||..|.|..:..:||...||.|::||.|||
  Rat   133 NIAAQLGAYAIQAELGDHDPCKHTAGYVSEYRFVPDQKEELEESIERIHKTLMGQAPSEAELNYL 197

  Fly   219 EHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLR 283
            ..||.||:||:|||.....|..|..||::.||::|:::..:|..:.|.::.||.||...|  :||
  Rat   198 RTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQF--ELR 260

  Fly   284 REPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR------PHRLSRFLNISLGSKFYYSG 342
            ....:..:|...|...|....|.|||..||||:|||:..      ..:||:|.:||.  |..|||
  Rat   261 VLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPETESNSLSRKLSKFGSISY--KHRYSG 323

  Fly   343 RTELQAVQE-SKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQ----QHSGSESAN---- 398
            ||.||..:: |.|..|.::..|||.||..                |.:    |.:||.|.|
  Rat   324 RTALQMSRDLSIQLPRPNQNVVRSRSKTY----------------PKRVAQTQPAGSNSINRMTA 372

  Fly   399 SHNNGKPAGAGTIL--TITKTSRPHDNKVTSKEADSMPRKAWEQ---QSDEYDIQLDVGFIEQ-- 456
            :..||:..|...|:  :..|:.:...|:.:.....|.....||:   ||..|:...|.....:
  Rat   373 NLENGENEGTTKIIAPSPVKSFKKAKNENSPDPQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFP 437

  Fly   457 CTRR--------FESASPSPMPPAYSSGQHSPI 481
            |||:        .:|:.|.....|:.||:.|.:
  Rat   438 CTRQRNLSCGSDNDSSQPMRRRKAHHSGEDSDL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	84/202 (42%)
		FERM_N	38..102	CDD:286467	25/68 (37%)
		FERM_M	125..232	CDD:278785	49/106 (46%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	34/93 (37%)
		FA	333..369	CDD:285894	16/36 (44%)
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
Epb41l4a	XP_006254645.1	B41	13..211	CDD:214604	84/202 (42%)
		FERM_N	15..80	CDD:286467	25/65 (38%)
		FERM_M	105..211	CDD:278785	49/105 (47%)
		FERM_C_NBL4_NBL5	207..296	CDD:270007	32/90 (36%)
		FA	311..354	CDD:285894	19/60 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910