DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Ptpn20

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001073618.1	Gene:	Ptpn20 / 306281	RGDID:	1309812	Length:	421	Species:	Rattus norvegicus

Alignment Length:	618	Identity:	147/618 - (23%)
Similarity:	223/618 - (36%)	Gaps:	227/618 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 SSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKT----------SRP-HDNKVTSKEADSMPR 435
            ||.|...|:|       ..:|.:..|....|.:.|:          ::| ..|||.|:...:...
  Rat     2 SSPGNVRQKH-------GRDNDEHEGDSDDLNLQKSLPSSSQQKTPTKPVFGNKVNSESVKTSHH 59

  Fly   436 KAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGS 500
            .::   |::||:                ..|.|:                           ||.:
  Rat    60 MSF---SNKYDL----------------VFPEPV---------------------------ESDN 78

  Fly   501 D--LITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHT--PADRCTPRVCEGDEVLMINGRDV 561
            |  |..:|                 |||...:.|.|.|.:  |:...:..:.|......::.|::
  Rat    79 DETLWDVR-----------------DLSHRNRWSSVDPESAGPSKTVSTVLSESSTDTAVSEREL 126

  Fly   562 HGLRHEQVV-------AMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNL 619
            ..|...:.:       |.:|||        |..::.:....::.|...|.:.:|..|
  Rat   127 TQLAQIRPLIFNSSSRAALRDC--------LKALQKKEELDIIREFLELEEMIPPDD-------- 175

  Fly   620 LDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVS 684
                             ..||     |||.                |..|||||||.|||.|||.
  Rat   176 -----------------FKSG-----YELQ----------------NRDKNRYRDILPYDSTRVP 202

  Fly   685 LVNSLTGDYINANYVNMEIPGGAVNR-----YIATQGPLASTTTDFWRMVQQESSHLLVMLTTVM 744
            |  ....|||||:|:.:      ||.     ||||||||..|..|||:||.:.:.:::.|:|..:
  Rat   203 L--GKNKDYINASYIRI------VNHEEEYFYIATQGPLPDTIEDFWQMVLENNCNVIAMITREI 259

  Fly   745 ESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREF--VLKDKHEQRHIHHMQYLAW 807
            |.|..||..||||:.:|....:.|.|  |.|....|..||.|.|  |.|...:...:.|:|::.|
  Rat   260 EGGVIKCCSYWPVSLKEPLEFKHFHV--LLENFQITQYFVIRIFQIVKKSTGKSHSVKHLQFIKW 322

  Fly   808 PDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGA 872
            |||..|:..:.|:::...||.
  Rat   323 PDHGTPASADFFIKYVRYVRK-------------------------------------------- 343

  Fly   873 TPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQ 937
                            |....|::||||||:|||||.|.:|.....:|.......::||..||.|
  Rat   344 ----------------SHITGPLLVHCSAGVGRTGVFICVDVVFCTIEKNYSFNIMNIVTQMRKQ 392

  Fly   938 RACMVQNVSQYRFVCECICAAYMKISRSSAAIN 970
            |..|:|...||:|..|.:    :::.::..|:|
  Rat   393 RFGMIQTKEQYQFCYEIV----LEVLQNLLALN 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	17/95 (18%)
		Y_phosphatase	666..955	CDD:278528	97/295 (33%)
		PTPc	668..955	CDD:238006	96/293 (33%)
Ptpn20	NP_001073618.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		14/62 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..116		5/22 (23%)
		PTPc	160..412	CDD:214550	106/371 (29%)
		PTPc	186..412	CDD:238006	96/299 (32%)
		Substrate binding. /evidence=ECO:0000250	354..360		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000