DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Ptpn14

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_008768075.1	Gene:	Ptpn14 / 305064	RGDID:	1307885	Length:	1189	Species:	Rattus norvegicus

Alignment Length:	1252	Identity:	277/1252 - (22%)
Similarity:	449/1252 - (35%)	Gaps:	414/1252 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VLFLDD--ITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQC 100
            :..||.  |..|..:|  :.|.|.|:.|.|.|||.|..||||.|..| ....|||:.:|..||.
  Rat    25 IRLLDSNVIECTLSVE--STGQECLEAVAQRLELRETHYFGLWFLSK-SQQARWVELEKPLKKH- 85

  Fly   101 SSVSLDNDA-VPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTV 164
                ||..| .|||.|.|.|:|...||||:|.||||:|||:|:::|.|:|.||......||...|
  Rat    86 ----LDKFANEPLLFFGVMFYVPSVSRLQQEATRYQYYLQVKKDVLEGRLRCSLEQVIRLAGLAV 146

  Fly   165 QSELGDFNALEHQ----PGYLSGMQLLCDQTT--EAERKVGELHKLHRGQLPADAEYNYLEHAKR 223
            |::.||:|..:.|    ...|..|.|..::..  |..:||.:.||.|.|.|||:||..|:...:|
  Rat   147 QADFGDYNQFDSQEFLREYVLFPMDLAMEEAALEELTQKVAQEHKAHSGILPAEAELMYINEVER 211

  Fly   224 LELYGIDLHRATDSNGKELQLGVSAVGLLVFQH-SLRVNTFSWSKMVKVSFKRKDFFIQL----- 282
            |:.:|.::....||:|..:.||:..:|:.|... ..:...:.|:.:..|:..:....::|
  Rat   212 LDGFGQEIFPVKDSHGNSMHLGIFFMGIFVRNRIGRQAVIYRWNDIGTVTHSKAAILLELIDKEE 276

  Fly   283 ----RREPSENYDTLLGFGMSSHKHAK------------------ALWK---------------- 309
                ..:..||...:.....:.||..|                  ..|.
  Rat   277 TALFHTDDIENAKYISRLFTTRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPMH 341

  Fly   310 -SCVEHHSFFRLKRP-----------------------------------HRLS------RFL-- 330
             .|.||:|.....:.                                   |.::      .|:
  Rat   342 VQCSEHYSETHTSQDSIFPGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSINSLSCSQSFIQA 406

  Fly   331 -----NISL-GSKFY-----------------YSGRTELQAVQESKQRGRIHKVFVRSPSKRLLG 372
                 |:|: ||...                 |....:.:.|....:||.:|    .....|.|.
  Rat   407 SPVSSNLSIPGSDIMRADYIPSHRHSTIIVPSYRPTPDYETVMRQMKRGLLH----ADSQSRSLR 467

  Fly   373 AAGGVGTS-------------------------GSSGGTPMQQHSGSESANSHNNGKPA--GAGT 410
            ....:.|.                         ...||...:..|.|:..|..|:..|:  |||:
  Rat   468 NLNIINTHAYNQPEELVYSQPEMRERHPYTVPYAPQGGYGHKLVSPSDQVNPQNSAMPSKPGAGS 532

  Fly   411 ILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMP----- 470
            |          .:.|::.|..:|..:..:..|..:.::         ...|....|.|.|
  Rat   533 I----------SHTVSTPELANMQLQGAQHYSTAHMLK---------NYLFRPPPPYPRPRPATS 578

  Fly   471 -PAYSSGQH------SPILLPTTI----------ADAVGHQQPESGSDLI--------------- 503
             |..:|.:|      ||.|:...:          :..|.||..:..|:.:
  Rat   579 TPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGGGGGAVNK 643

  Fly   504 ------------------------------TIRLQADEQGRYGFNVKG---------GVDLSLPV 529
                                          |:|.|...:...|.:|.|         ..|.::.:
  Rat   644 RHSLEVMNSMVRGMEAMTLKSLNIPMARRNTLREQGPSEEAGGHDVHGLPQYHHKKTFSDATMLI 708

  Fly   530 QVSKVVPHTPADRCTPRVCE---------------------------GDEVLMINGRDVHGLRHE 567
            ..|:......|....|::.|                           |....:.||.    ||.:
  Rat   709 HSSESEEEEEAPEAAPQIPELREKVEYSAQLQAALARIPSRPPPEYPGPRKSVSNGT----LRQD 769

  Fly   568 Q-----VVAMIRDCRHQASGELLL-----------TVRPQRSAPLL------LEEEPLYQYVPES 610
            |     .:|..|..||..:..|.:           ::.|..|.|.|      :::||:.:. |.|
  Rat   770 QGTLLPAMARARVLRHGPAKALSVSRAEQLAVNGASLGPSISEPDLTSVKERVKKEPVKER-PVS 833

  Fly   611 DEIGSHSNLLDGDAL----------------------------------------------FTQS 629
            :......::::.:.:                                              ..:.
  Rat   834 EMFSLEDSIIEREMMIRNLEKQKMTGLQAQKRPLMLAALNGLSVARVSGREDGRHDVTRVPMDER 898

  Fly   630 LLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLV---NSLTG 691
            |..|...|..|.:..:||.:..|..:...:.|..|.||.::|.|::.||:..||.|:   .:.||
  Rat   899 LRALKKKLEDGMVFTEYEQIPNKKANGIFSTATLPENAERSRIREVVPYEENRVELIPTKENNTG 963

  Fly   692 DYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWP 756
             ||||:::.: :.||:...||||||||..|..|||:||.::..:::.|:|...|.||.|.|:|||
  Rat   964 -YINASHIKV-VVGGSEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWP 1026

  Fly   757 VTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKH----EQRHIHHMQYLAWPDHCVPSDPN 817
            ..|.:...|.....:..::...::|.:....  ||.||    ::|.:.|:||..||.|..|.|..
  Rat  1027 KLGSKHSSATYGKFKVTTKFRTDSGCYATTG--LKVKHLLSGQERTVWHLQYTDWPHHGCPEDVQ 1089

  Fly   818 LFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVST 882
            .||.:.|.:::.|..|                                                .
  Rat  1090 GFLSYLEEIQSVRRHT------------------------------------------------N 1106

  Fly   883 SVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQ 947
            ||.:.:...:||::||||||:|||||:||.:..:..:|..|.|....::|.:|:||..|:|.::|
  Rat  1107 SVLEGVKTRHPPIVVHCSAGVGRTGVVILSELMIYCLEHNEKVEVPTMLRFLREQRMFMIQTIAQ 1171

  Fly   948 YRFVCECICAAYMKISR 964
            |:||.: :...:::.||
  Rat  1172 YKFVYQ-VLVQFLQNSR 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	81/202 (40%)
		FERM_N	38..102	CDD:286467	26/65 (40%)
		FERM_M	125..232	CDD:278785	45/112 (40%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	21/138 (15%)
		FA	333..369	CDD:285894	8/53 (15%)
		PDZ_signaling	502..589	CDD:238492	22/183 (12%)
		Y_phosphatase	666..955	CDD:278528	92/295 (31%)
		PTPc	668..955	CDD:238006	90/293 (31%)
Ptpn14	XP_008768075.1	B41	24..220	CDD:214604	81/202 (40%)
		PH-like	215..305	CDD:418428	16/89 (18%)
		PTPc-N14	898..1184	CDD:350447	101/338 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810