DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Epb41l5

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_038946598.1	Gene:	Epb41l5 / 304733	RGDID:	1311366	Length:	731	Species:	Rattus norvegicus

Alignment Length:	666	Identity:	200/666 - (30%)
Similarity:	296/666 - (44%)	Gaps:	118/666 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSS 102
            |..||....:..:.|:|||.||.||:..:|:|.|.|||||.| .....|..|:|..|..|||...
  Rat    47 VSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRF-MDSAQVAHWLDGTKSIKKQVKI 110

  Fly   103 VSLDNDAVP-LLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQS 166
            .|      | .|..||||:.|:|:.|:||.|||.|.||:|::||.|||.|..:|...||:|.:|:
  Rat   111 GS------PYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLECPFDTAVQLAAYNLQA 169

  Fly   167 ELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDL 231
            ||||::..||.|..:|..:.:..||.|.|..:.|..|.:|||.||.||.|||..||.||:||:|:
  Rat   170 ELGDYDLAEHSPELVSEFRFVPTQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDM 234

  Fly   232 HRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREP---SENYDTL 293
            |.....:|.:..||::..|:|||:...::..|.|.|:.::.||:....:.:..:.   .|...|.
  Rat   235 HVVKARDGNDYSLGLTPTGVLVFEGETKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTF 299

  Fly   294 LGFGMSSHKHAKALWKSCVEHHSFFRLKRP-----HRLSRFLNISLGSKFYYSGRTELQAVQESK 353
            : |.:...|..|.|||..||||:||||:.|     || |.|  |.|||:|.|||:||.|..:.:|
  Rat   300 V-FRLDHPKACKHLWKCAVEHHAFFRLRGPVQKGSHR-SGF--IRLGSRFRYSGKTEYQTTKTNK 360

  Fly   354 QRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTS 418
            .|....  |.|.||||.......|..|     |......|..:|::.||......|....:..||
  Rat   361 ARRSTS--FERRPSKRYSRRTLQVKAS-----TAKPDDLGVHNASAQNNDSQQAWGMKSPVPVTS 418

  Fly   419 RPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILL 483
            ......|. .|.:::|:.:...|.|...:.|.:..:                       :||.||
  Rat   419 FSSSGPVL-VETENLPQNSAADQHDRKRLPLSIDLL-----------------------NSPDLL 459

  Fly   484 PTTIAD--------------------AVGHQQPESGSDLITIR------LQADEQGRYGFNVKGG 522
            .|||.|                    .:.|:..|..:|..|::      .|.:.:.....:::..
  Rat   460 ETTIGDVTRPSDTSAPFPAPDDVNVATMSHELEELRADCETLKDDTEKLKQLNTEQNILPSLRPA 524

  Fly   523 VDLSLPVQVSKVVPHTPADRCTPRVCEG-------------DEVLMINGRDVHGLRHEQVV---- 570
            :|:::..| .:||..|  ::|.....|.             ..:|......||....|..:
  Rat   525 IDINVNSQ-EEVVKLT--EKCLNNAIESPGLNTVRVPPDFKSNILKAQVEAVHKATREDSLLTHK 586

  Fly   571 -AMIRDCRHQASGELLLTVRPQRSAPLLLEE-EPLYQYVPESDEIGSHSNLLDG----DALFTQS 629
             |.::|....:      ||..:.:.||..:. .|::....:||.:     |.|.    |||
  Rat   587 NASVQDAATNS------TVFNENNMPLCKDSLTPVHGTTADSDSV-----LKDATDELDAL---- 636

  Fly   630 LLLLSDGLASGALLAQ 645
            ||.|::.|....:..|
  Rat   637 LLSLTENLMDHTVTPQ 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	88/194 (45%)
		FERM_N	38..102	CDD:286467	27/63 (43%)
		FERM_M	125..232	CDD:278785	52/106 (49%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	30/96 (31%)
		FA	333..369	CDD:285894	16/35 (46%)
		PDZ_signaling	502..589	CDD:238492	16/110 (15%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
Epb41l5	XP_038946598.1	B41	44..235	CDD:214604	88/194 (45%)
		FERM_C_NBL4_NBL5	231..324	CDD:270007	28/93 (30%)
		FA	337..378	CDD:400882	20/44 (45%)
		ZIP_TSC22D-like	<477..510	CDD:424092	4/32 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910