DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Ptpn18

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_038939136.1	Gene:	Ptpn18 / 301333	RGDID:	1311586	Length:	459	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	109/352 - (30%)
Similarity:	156/352 - (44%)	Gaps:	88/352 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   640 GALLAQ--YELMYR----KNPDLAITEA-RKPANAPKNRYRDISPYDCTRVSLVNSLT-----GD 692
            ||:||:  .::..|    |...:..|:| .:..|:.||||:|:.|||.|||.|  ||.     ||
  Rat    23 GAILAREFSDIKARSVAWKTEGVCSTKAGSQQGNSKKNRYKDVVPYDETRVIL--SLLQEEGHGD 85

  Fly   693 YINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV 757
            |||||::.......|   ||||||||..|..||||:|.:....:::|.....|:||:||.:||..
  Rat    86 YINANFIRGTDGSQA---YIATQGPLPHTLLDFWRLVWEFGVKVILMACQETENGRRKCERYWAQ 147

  Fly   758 TGEELQLAEGFSVRCLSEKPDETGSFVFR------EFVLKDKHEQRHIHHMQYLAWPDHCVPSDP 816
            ..|.|| |..|.: .|:::...|.....|      :.|.|.:.|.|.:|.:||::||||.|||..
  Rat   148 EREPLQ-AGPFCI-TLTKETALTADITLRTLQVTFQKVPKGQKESRPVHQLQYMSWPDHGVPSSS 210

  Fly   817 NLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVS 881
            :..|...|..|
  Rat   211 DHILTMVEEAR------------------------------------------------------ 221

  Fly   882 TSVHQCISAANP-PVIVHCSAGIGRTGVLILMD--TALALMEAREPVYPL-DIVRTMRDQRACMV 942
                 |:....| |:.||||||.||||||..:|  ..|.|.:...|.:.| ::|..||.||...|
  Rat   222 -----CLQGLGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFEVVLEMRKQRPAAV 281

  Fly   943 QNVSQYRFVCECICAAYMKISRSSAAI 969
            |...||||:...:...:.:..::::.:
  Rat   282 QTEEQYRFLYHTVAQLFSRTLQNNSPL 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528	101/303 (33%)
		PTPc	668..955	CDD:238006	100/301 (33%)
Ptpn18	XP_038939136.1	PTP_DSP_cys	27..298	CDD:421693	106/336 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910