DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Frmd3

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_038965420.1	Gene:	Frmd3 / 298141	RGDID:	1304802	Length:	595	Species:	Rattus norvegicus

Alignment Length:	407	Identity:	134/407 - (32%)
Similarity:	205/407 - (50%)	Gaps:	39/407 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLF--PQKPGDVVRW 89
            |...|..:| |:..|||...:.||::..||..|::.:..|..|.|:||||:.:  |:|..   .|
  Rat    26 KSLNQEMKC-TIRLLDDSEVSCRIQRETKGQFLIEYICNYYSLLEKDYFGIRYVDPEKQR---HW 86

  Fly    90 VDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSN 154
            ::..|...||..|     .....:.|||||:..:|.:::||.|||..||||||:|..|:|.||..
  Rat    87 LEPNKSIFKQMKS-----HPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFT 146

  Fly   155 TQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLH-RGQLPADAEYNYL 218
            ....|.:..||:|.||:...||...|:|..::...|:.:.|||:.|:|... |||.||.||:|.|
  Rat   147 DAAYLGACIVQAEFGDYYPDEHPENYISEFEIFPKQSQKLERKIMEIHNNELRGQSPAMAEFNLL 211

  Fly   219 EHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLR 283
            ..|..||.||:|.|...||.|....||.:|.|.:|||.:.|::...||.:.|:.|:.|.|:: :.
  Rat   212 LKAHTLETYGVDPHPCKDSRGATAFLGFTAAGFVVFQGNKRIHLRKWSDVCKLKFEGKTFYV-IG 275

  Fly   284 REPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISL---GSKFYYSGRTE 345
            .:..:|  .:|.|..|:....|.|||..||:.:|::..:..::....:..:   ||:|.|||:..
  Rat   276 SQKEKN--AVLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFRYSGKVA 338

  Fly   346 LQAVQESKQRGR----IHKVFV---RS-------------PSKRLLGAAGGVGTSGSSG-GTPMQ 389
            .:.|:.|.:..|    :|:|.:   ||             |.:.||.:..........| |||:.
  Rat   339 KEVVEASSKIQRDPPEVHRVNITQSRSFHSLNKQLIINMEPLQPLLPSPTEQEEEVPMGEGTPLP 403

  Fly   390 QHSGSESANSHNNGKPA 406
            :...|||..|.:..|.|
  Rat   404 KMDVSESLISSSPVKGA 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	77/199 (39%)
		FERM_N	38..102	CDD:286467	21/65 (32%)
		FERM_M	125..232	CDD:278785	47/107 (44%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	32/93 (34%)
		FA	333..369	CDD:285894	14/58 (24%)
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
Frmd3	XP_038965420.1	B41	33..225	CDD:214604	77/200 (39%)
		PH-like	206..309	CDD:418428	39/105 (37%)
		FA	323..365	CDD:400882	11/41 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910