DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and msna

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001004296.1	Gene:	msna / 286739	ZFINID:	ZDB-GENE-021211-2	Length:	579	Species:	Danio rerio

Alignment Length:	331	Identity:	93/331 - (28%)
Similarity:	156/331 - (47%)	Gaps:	40/331 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 FRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPL 112
            |.|:....|.:|.|||.:.:.|.|..:|||.:....| ...|:    :..|:.::..:..::..|
Zfish    18 FAIQPSTTGKQLFDQVVKTIGLREVWFFGLQYQDTKG-FSTWL----KLNKKVTAQDVRKESPLL 77

  Fly   113 LEFRVKFFVSDPS-RLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEH 176
            .:||.||:..|.| .|.:|.|:..|:||:|..||...:.|...|..|||||.||::..|:|...|
Zfish    78 FKFRAKFYPEDVSEELIQEATQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQAKYADYNKDAH 142

  Fly   177 QPGYLSGMQLLCDQTTEA--------ERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHR 233
            .|||||..:||..:..|.        |.::...|:.|:|.|..|:...||:.|:.||:||::...
Zfish   143 TPGYLSNEKLLPQRVLEQHKLNKEQWEERIQVWHEEHKGMLREDSMMEYLKIAQDLEMYGVNYFS 207

  Fly   234 ATDSNGKELQLGVSAVGLLVFQHSLRVNT---FSWSKMVKVSFKRKDFFIQLRREPSENYDTLLG 295
            ..:..|.||.|||.|:||.:::.:.::..   |.||::..:||..|.|.|    :|.:.......
Zfish   208 IKNKKGSELWLGVDALGLNIYEQNDKMTPKIGFPWSEIRNISFNDKKFVI----KPIDKKAPDFV 268

  Fly   296 FGMSSHKHAKALWKSCVEHHS-FFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIH 359
            |.....:..|.:...|:.:|. :.|.::|..:                  |:|.::...:..:.|
Zfish   269 FYAQRLRINKRILALCMGNHELYMRRRKPDTI------------------EVQQMKAQAKEEKNH 315

  Fly   360 KVFVRS 365
            |...|:
Zfish   316 KKMERA 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	64/192 (33%)
		FERM_N	38..102	CDD:286467	15/53 (28%)
		FERM_M	125..232	CDD:278785	43/115 (37%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	24/97 (25%)
		FA	333..369	CDD:285894	5/33 (15%)
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
msna	NP_001004296.1	B41	7..206	CDD:214604	64/192 (33%)
		FERM_N	9..71	CDD:286467	15/57 (26%)
		FERM_M	91..206	CDD:278785	42/114 (37%)
		FERM_C_ERM	200..296	CDD:270015	25/99 (25%)
		ERM	347..579	CDD:279153
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910