DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Epb41

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_006538970.1	Gene:	Epb41 / 269587	MGIID:	95401	Length:	1025	Species:	Mus musculus

Alignment Length:	974	Identity:	260/974 - (26%)
Similarity:	409/974 - (41%)	Gaps:	210/974 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGL-LFPQKPG 84
            ||.::......|.....|..|||..:...:||.|||.:||.:|.::|.|.|.||||| |:.....
Mouse   198 PEASQKPVRRHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLALWDSATS 262

  Fly    85 DVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKL 149
            ..  |:|:.|:.|||...|..:      ..|.|||:..||::|.|:.|||...||::::|:.|:|
Mouse   263 KT--WLDSAKEIKKQVRGVPWN------FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRL 319

  Fly   150 PCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAE 214
            |||..|..||.|||:||||||::...|...|:|..:|..:||.|.|.||.||||.:|...||.|:
Mouse   320 PCSFATLALLGSYTIQSELGDYDPELHGMDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQAD 384

  Fly   215 YNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFF 279
            ..:||:||:|.:||:|||:|.|..|.::.|||.:.||||::..||:|.|.|.|::|:|:||..||
Mouse   385 LEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 449

  Fly   280 IQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRT 344
            |::|....|:|::.:||.:.|::.||.|||.|||||:||||.....:.:...::|||||.|||||
Mouse   450 IKIRPGEQEHYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRT 514

  Fly   345 ELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAG 409
            :.|..|.|....|....|.|:.|||...:..|...:.|:..:|                :|..|.
Mouse   515 QAQTRQASALIDRPAPHFERTASKRASRSLDGAAAAESTDRSP----------------RPTSAP 563

  Fly   410 TILTITKTSRP-HDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAY 473
            .|.....|..| ...|.|.|||..:..|..|:.:                   |.|.|.|.....
Mouse   564 AIAQSQVTEGPGAPIKKTPKEAVKVEEKRGEEPA-------------------EPAEPEPTEAWK 609

  Fly   474 SSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHT 538
            ....|:.:.:||:..|.. .:....|.|||.:|.:..|:
Mouse   610 VEKTHTEVTVPTSNGDQT-QKLAGKGEDLIRMRKKKRER-------------------------- 647

  Fly   539 PADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDC--------RHQAS-GELLLTVRPQRSA 594
                             ::|.::: :||..:  |:.|.        :|.|| .||
Mouse   648 -----------------LDGENIY-IRHSNL--MLEDLDKSQEEIKKHHASISEL---------- 682

  Fly   595 PLLLEEEPLYQYVPE------SDEIGSHS---------NLLDGDALFTQSLLLLSDGLASGALLA 644
                 ::...:.|||      ...:.:||         .:..||.:...|:      |.||..:.
Mouse   683 -----KKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQVPTGDGVKKTSI------LPSGRKVG 736

  Fly   645 QYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVN 709
            ..|.:.....:...|..:.|:..|      .|.::|.:.|:|.|.:         .|..|..:..
Mouse   737 GPESVNGIRTEEVATVTKGPSTYP------ASEWECPKQSVVPSQS---------LMTTPPASPQ 786

  Fly   710 RYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESG------RQKCHQYWPVTGEELQLAEGF 768
            .:  ..|.|:..:.:.....|..:.:|.........||      .|.....:|||....||..|
Mouse   787 SF--GSGSLSINSKEAEEKEQGAAGYLDAEEMPTGPSGECLGVEEQASAFSFPVTPASCQLQLG- 848

  Fly   769 SVRCLSEKPD--------------ETGSF----VFREFVLKDKHEQRHIHHMQYLAWPD--HCVP 813
                 .||.|              ::|||    |..:|....:..|..:...|.:...|  :.|.
Mouse   849 -----GEKADSSEELGAAAETLETQSGSFLDSPVGNQFPTLIRSFQPPLVKTQTVTISDTANAVK 908

  Fly   814 SD---PNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPE 875
            |:   .::.:..||      .:|:..|..::        .|::.|.:.|::...:...|...:..
Mouse   909 SEIPTKDVPIVHTE------TKTITYEAAQT--------EDSNGDLDPGVLLTAQTITSETTSST 959

  Fly   876 DETPVSTSVHQCISAA--NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQ 937
            ..|.::.:|...||..  ...:::...|.|....||:     .|:.||:|....:.:.:.:..|
Mouse   960 TTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLV-----QAIKEAKEQHPDMSVTKVVVHQ 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	85/197 (43%)
		FERM_N	38..102	CDD:286467	27/64 (42%)
		FERM_M	125..232	CDD:278785	51/106 (48%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	46/93 (49%)
		FA	333..369	CDD:285894	17/35 (49%)
		PDZ_signaling	502..589	CDD:238492	14/95 (15%)
		Y_phosphatase	666..955	CDD:278528	55/303 (18%)
		PTPc	668..955	CDD:238006	55/301 (18%)
Epb41	XP_006538970.1	B41	212..402	CDD:214604	85/197 (43%)
		FERM_C_4_1_family	397..490	CDD:270005	46/92 (50%)
		FA	500..542	CDD:370090	19/41 (46%)
		SAB	662..709	CDD:367916	11/61 (18%)
		4_1_CTD	915..1021	CDD:368659	21/123 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910