DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and stn-1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_492521.1	Gene:	stn-1 / 266844	WormBaseID:	WBGene00006062	Length:	440	Species:	Caenorhabditis elegans

Alignment Length:	431	Identity:	83/431 - (19%)
Similarity:	144/431 - (33%)	Gaps:	134/431 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 SASPSPMPPAYSSGQHSPILL---PTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVD 524
            :|..|.:...:..||...:|.   ||.|. ....:|.|:.::..|:|:...:....|.::|||.|
Worm     2 AAVRSGLVDIFVQGQWHRVLATLDPTAIT-LQTMEQNEAEAEKRTVRVVKYDGNGLGISIKGGRD 65

  Fly   525 LSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVR 589
            .::|:.:||:.....||:......: |.::.:||.::....||:.|..::    :|...:.|.|:
Worm    66 NNMPIVISKIFKGMAADQAGELFLD-DVIISVNGENLLDASHEEAVRALK----RAGRVVDLQVQ 125

  Fly   590 PQRSAPLLLEEEPLYQYVPESDEIG---------------------------------------- 614
            .:|..  ::..|.:.:.|...|:|.
Worm   126 YRRED--MMHRENIVENVEWDDDIRERVRTIGLKLAYVARAGIDADAEGRILEMRSPSGRYSLAM 188

  Fly   615 --SHSNLLDG--DALFTQSLLLLSDGLA------------------------SGALLAQYELMYR 651
              |.|...||  :||...:..||:..||                        :|..:.:.:.|..
Worm   189 RCSSSEEADGWFEALHACTTCLLTQALAQVNIMLGNNPQVRHMGWIAEQVSENGISMWKPKFMTL 253

  Fly   652 KNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYIN--------------------- 695
            .|.::...||.....|.....|.:.|...|||...:|.|...|.
Worm   254 TNSEILFYEAVPQLKAEWAEPRLVRPLVATRVVQTSSRTAPVIKGLTDVISFRMRTGTQQGVRTH 318

  Fly   696 ----------ANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVML---TTVMESG 747
                      |.:|...:.||    |.|.......:....||   .||..|:|.|   .:::.|
Worm   319 TIRVETHAELARWVRAVVIGG----YEACLSTSQVSAPCLWR---GESCELIVNLDNGISLLSS- 375

  Fly   748 RQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREF 788
                      |||.|......::|...   |:.|.|::.:|
Worm   376 ----------TGEVLWQHSFETIRATG---DDGGRFLWVDF 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	20/86 (23%)
		Y_phosphatase	666..955	CDD:278528	32/157 (20%)
		PTPc	668..955	CDD:238006	31/155 (20%)
stn-1	NP_492521.1	PDZ_signaling	44..125	CDD:238492	20/85 (24%)
		PH-like	<152..208	CDD:302622	6/55 (11%)
		PH	228..334	CDD:278594	16/105 (15%)
		PH	228..334	CDD:214574	16/105 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910