DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Frmd6

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_006240213.1	Gene:	Frmd6 / 257646	RGDID:	727810	Length:	622	Species:	Rattus norvegicus

Alignment Length:	650	Identity:	132/650 - (20%)
Similarity:	245/650 - (37%)	Gaps:	145/650 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWV 90
            :.|..|.::.|.:...:|.:.:..|..:....:||.||...|.|.:...|||...|....|...:
  Rat     8 NNKVMQDRRRVCIFLPNDKSVSIIINVKILCHQLLVQVCDLLRLKDSHLFGLSVIQNNEHVYMEL 72

  Fly    91 DAQ------KQFKKQCSSV-------SLDNDAVP-LLEFRVKFFVSDPSRLQEEFTRYQFYLQIK 141
            ..:      |::||:.|.|       .:|....| ::.|||:::|.:...:.:...||.:|..::
  Rat    73 SQKLYKYCPKEWKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENGKLISDRIARYYYYWHLR 137

  Fly   142 RNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERK---VGELHK 203
            :.:|..:.........|||::.:|::||:|....|...|................|   :..:..
  Rat   138 KQVLHSQCVLREEAYFLLAAFALQADLGNFKRKVHHGDYFEPEAYFPAWVVSKRGKDYILKHIPN 202

  Fly   204 LHRGQL---PADAEYNYLEHAKRLELYGIDLHRA-TDSNGKE--LQLGVSAVGLLVFQH----SL 258
            :||.|.   .::|...|::.|.||:...|..:|. .|....|  |.||::..|:.:||:    ..
  Rat   203 MHRDQFALTASEAYLKYIKEAVRLDDVAIHYYRLYKDKREVEGSLTLGLTMRGIQIFQNLEEEKQ 267

  Fly   259 RVNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKAL--WKSCV--EHHSFFR 319
            .:..|.|:.:.|:.|..|.|             .:|..|:.|   |:.|  :..|.  ..|....
  Rat   268 LLYDFPWTNVGKLVFVGKKF-------------EILPDGLPS---ARKLVYYTGCPTRSRHLLQL 316

  Fly   320 LKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFV-------RSPSKRLLGAAGGV 377
            |...|||  ::|:....:       .|:..:|::::.:..:.::       ..|.::...|:|
  Rat   317 LSNSHRL--YMNLQPVLR-------HLRKQEENEEKKQYRESYISDNLDLDMDPLEKRSRASG-- 370

  Fly   378 GTSGSSGGTPMQQHSGSESANSHNNG-----KPAGAG---------------TILTITKTSRPHD 422
            .::||.....:.:||.:..::||.:|     ||...|               |..::|.....|.
  Rat   371 SSAGSMKHKRLSRHSTASHSSSHTSGIETDTKPRDPGPEDGYSGSVMHRKLKTCSSMTSHGSSHT 435

  Fly   423 NKVTSKEADSMPRKAWEQQSDEYDIQL-DVGFIEQCTRRFESASPSPMPPAYSS---------GQ 477
            :.|.|...|.:..   :.|.||.::.: |...:|..|.  ||...||....|.:         ..
  Rat   436 SGVESGGKDRLEE---DSQDDEIEMLVDDPRDLEPMTE--ESLEVSPEMCIYITQDMLLSRKLNG 495

  Fly   478 HSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADR 542
            ||.:     |...:......|...::.:|.|:.:              |||..:.: .|.|..||
  Rat   496 HSGL-----IVKEISSSTSSSSETVVKLRGQSTD--------------SLPQTICR-KPKTSTDR 540

  Fly   543 CTPRVCEGDEVLMINGRD---VHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLY 604
            .:..:   |::.:.. :|   :.||..:...:....|.|:                  |:|..||
  Rat   541 HSLSL---DDIRLYQ-KDFLRIAGLCQDTAQSYTFGCGHE------------------LDESGLY 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	48/216 (22%)
		FERM_N	38..102	CDD:286467	16/69 (23%)
		FERM_M	125..232	CDD:278785	23/112 (21%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	23/104 (22%)
		FA	333..369	CDD:285894	3/42 (7%)
		PDZ_signaling	502..589	CDD:238492	15/89 (17%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
Frmd6	XP_006240213.1	B41	20..234	CDD:214604	47/213 (22%)
		FERM_N	20..82	CDD:286467	13/61 (21%)
		FERM_M	123..234	CDD:278785	23/110 (21%)
		FERM_C_FRMD1_FRMD6	227..335	CDD:270006	28/132 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910