DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Nf2

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_006251250.1	Gene:	Nf2 / 25744	RGDID:	3169	Length:	596	Species:	Rattus norvegicus

Alignment Length:	344	Identity:	97/344 - (28%)
Similarity:	160/344 - (46%)	Gaps:	50/344 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDN 107
            |....|..|.:.||.:|.|.|.:.|.|.|..:|||.:..|  |.|.|:...|:.        ||:
  Rat    30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIK--DTVAWLKMDKKV--------LDH 84

  Fly   108 DA---VPL-LEFRVKFFVSD-PSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSE 167
            |.   .|: ..|..||:..: ...|.:|.|::.|:||:|:.||..|:.|......|||||.||::
  Rat    85 DVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKVYCPPEASVLLASYAVQAK 149

  Fly   168 LGDFNALEHQPGYLSGMQL-------LCDQTTEA-ERKVGELHKLHRGQLPADAEYNYLEHAKRL 224
            .||::...|:.|:|:..:|       |...|.|. |.::...:..|||:...:||..||:.|:.|
  Rat   150 YGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDL 214

  Fly   225 ELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVN---TFSWSKMVKVSFKRKDFFIQLRREP 286
            |:||::.....:..|.||.|||.|:||.::....|:.   :|.|:::..:|:..|:|.|    :|
  Rat   215 EMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTI----KP 275

  Fly   287 SENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQE 351
            .:....:..|..|..:..|.:.:.|:.:|..|..:|                    :.:...||:
  Rat   276 LDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRR--------------------KADSLEVQQ 320

  Fly   352 SKQRGRIHKVFVRSPSKRL 370
            .|.:.|..|...:...:||
  Rat   321 MKAQAREEKARKQMERQRL 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	66/201 (33%)
		FERM_N	38..102	CDD:286467	19/58 (33%)
		FERM_M	125..232	CDD:278785	40/114 (35%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	25/96 (26%)
		FA	333..369	CDD:285894	5/35 (14%)
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
Nf2	XP_006251250.1	B41	23..222	CDD:214604	66/201 (33%)
		FERM_N	26..87	CDD:286467	22/66 (33%)
		FERM_M	107..222	CDD:278785	40/114 (35%)
		FERM_C_ERM	216..312	CDD:270015	26/119 (22%)
		14-3-3	334..>487	CDD:295170	2/6 (33%)
		ERM	347..596	CDD:279153
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910