DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Ptprz1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_037212.2	Gene:	Ptprz1 / 25613	RGDID:	3455	Length:	2316	Species:	Rattus norvegicus

Alignment Length:	1121	Identity:	243/1121 - (21%)
Similarity:	381/1121 - (33%)	Gaps:	362/1121 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DITHTFR-----IEKRAKGSELLDQVFQYLELSERDYFGLLFPQKP------GDVV-RWVDAQKQ 95
            |.|:|..     |:..:||..:..   ...||....:..:.:|.|.      .|:| :|.::.|:
  Rat  1034 DFTYTTSVSGDDIKPLSKGEMMYG---NETELKMSSFSDMAYPSKSTVVPKMSDIVNKWSESLKE 1095

  Fly    96 FKKQCSSVS---LDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQC 157
            .....||::   .::...|:    .|.|..:.||:.|              |:....|..:.:|.
  Rat  1096 TSVSVSSINSVFTESLVYPI----TKVFDQEISRVPE--------------IIFPVKPTHTASQA 1142

  Fly   158 -----LLASYTVQSELGDFNALEHQPGYLSGMQLLCDQ----TTEA----ERKVGELHKLHRGQL 209
                 |....:..||....:....:..:.|...||.:.    .|||    .....::..|.:..|
  Rat  1143 SGDTWLKPGLSTNSEPALSDTASSEVLHPSTQPLLYEAASPFNTEALLQPSFPASDVDTLLKTAL 1207

  Fly   210 PADAEYNYLEHAKRLE--LYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVS 272
            |:......|.....:|  ...:.|..|::|...:..|..::|.:|....| .|:..|..::. |.
  Rat  1208 PSGPRDPVLTETPMVEQSSSSMSLPLASESASSKSTLHFTSVPVLNMSPS-DVHPTSLQRLT-VP 1270

  Fly   273 FKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLG-- 335
            ..|:::|.|               |:...|..:.:..|...|..||:       :..|:||..
  Rat  1271 HSREEYFEQ---------------GLLKSKSPQQVLPSLHSHDEFFQ-------TAHLDISQAYP 1313

  Fly   336 SKFYYSGRTELQAVQESKQR--GRI---HKVF----VRSPSKRLLGAAGGVGTSGSSGGTPMQQH 391
            .|..::..|.:.::.|.:..  .|:   ..:|    :....|.|.|....|
  Rat  1314 PKGRHAFATPILSIDEPQNTLISRLVYSEDIFMHPEISITDKALTGLPTTV-------------- 1364

  Fly   392 SGSESANSHNNGKPAGAGTI------------LTITKTSRPHDNKVTSK---------------- 428
              |:...:.::..|.|:|.|            :|.||...|  :|.|||
  Rat  1365 --SDVLIATDHSVPLGSGPISMTTVSPNRDDSVTTTKLLLP--SKATSKPTHSARSDADLVGGGE 1425

  Fly   429 -------------EADSMP----------RKAWEQQSDEYDIQLDVGFIEQ-------------- 456
                         ::|..|          |::.|:..::.|.| :...::|
  Rat  1426 DGDDYDDDDYDDIDSDRFPVNKCMSCSPYRESQEKVMNDSDTQ-ESSLVDQSDPISHLLSENTEE 1489

  Fly   457 ------CTRRFESASPSP----MPPAYSSGQH-------SPIL--LPTTIADAVGHQQPESGSDL 502
                  .||..:|...||    :|..::.|:.       |.:|  .|.:.|.||.....||||..
  Rat  1490 ENGGTGVTRVDKSPDKSPPPSMLPQKHNDGREDRDIQMGSAVLPHTPGSKAWAVLTSDEESGSGQ 1554

  Fly   503 ITIRLQADEQGRYGFNV----KGGVDLSLPVQVSKVVPHTPADRCTPRVCEG-------DEVLMI 556
            .|.....|.:....|:.    :...|..|....:.:.|.:|.. .||.|..|       .|....
  Rat  1555 GTSDSLNDNETSTDFSFPDVNEKDADGVLEADDTGIAPGSPRS-STPSVTSGHSGVSNSSEAEAS 1618

  Fly   557 NGRD------VHGLRHEQ--------VVAMIRDCRHQASGELLLTVRPQRSAPLLLEEE------ 601
            |...      ..||..|:        |.|:...|.....|.|:...:..::|...||:.
  Rat  1619 NSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDNTSPRVI 1683

  Fly   602 -----PLYQYVPESDEIGS--------HSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKN 653
                 |::   |.||:||:        |...|.....||:....|.:         .|:.:....
  Rat  1684 STPPTPIF---PISDDIGAIPIKHFPKHVADLHASNGFTEEFETLKE---------FYQEVQSCT 1736

  Fly   654 PDLAIT--EARKPANAPKNRYRDISPYDCTRVSLV------NSLTGDYINANYVNMEIPGGAVNR 710
            .||.||  .:..|.|..||||.:|..||.:||.|.      ..|| ||||||||:      ..||
  Rat  1737 VDLGITADSSNHPDNKHKNRYVNIVAYDHSRVKLTQLAEKDGKLT-DYINANYVD------GYNR 1794

  Fly   711 ---YIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRC 772
               |||.||||.||..|||||:.:.:..::||:|.::|.||:||.||||..|.|
  Rat  1795 PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPTDGSE----------- 1848

  Fly   773 LSEKPDETGSFV-------------FREFVL----------KDKHEQRHIHHMQYLAWPDHCVPS 814
                  |.|||:             .|.|.|          |.:...|.:....|..|||..||.
  Rat  1849 ------EYGSFLVNQKNVQVLAYYTVRNFTLRNTKIKKGSQKGRSSGRLVTQYHYTQWPDMGVPE 1907

  Fly   815 DPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETP 879
            .....|.|..:...|:..
  Rat  1908 YSLPVLAFVRKTAQAKRH----------------------------------------------- 1925

  Fly   880 VSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQN 944
                       |..||:||||||:||||..|::|:.|..::....|.....::.:|.||..:||.
  Rat  1926 -----------AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQT 1979

  Fly   945 VSQYRFVCECICAAYM 960
            ..||.|:.:.:..|.:
  Rat  1980 EEQYVFIHDTLVEAIL 1995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	39/218 (18%)
		FERM_N	38..102	CDD:286467	14/70 (20%)
		FERM_M	125..232	CDD:278785	20/121 (17%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	19/93 (20%)
		FA	333..369	CDD:285894	6/46 (13%)
		PDZ_signaling	502..589	CDD:238492	21/111 (19%)
		Y_phosphatase	666..955	CDD:278528	94/320 (29%)
		PTPc	668..955	CDD:238006	93/318 (29%)
Ptprz1	NP_037212.2	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..537
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..624
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1141..1172		4/30 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1401..1521		19/122 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1622		17/77 (22%)
		PTPc	1717..1992	CDD:214550	103/365 (28%)
		PTPc	1753..1992	CDD:238006	93/320 (29%)
		Substrate binding. /evidence=ECO:0000250	1934..1940		4/5 (80%)
		PTPc	2023..2281	CDD:214550
		PTPc	2051..2281	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910