DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Fgd4

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_038943909.1	Gene:	Fgd4 / 246174	RGDID:	708357	Length:	887	Species:	Rattus norvegicus

Alignment Length:	677	Identity:	134/677 - (19%)
Similarity:	221/677 - (32%)	Gaps:	215/677 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 TSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILT--------------ITKTSRPHDNKVTSKE 429
            ||.:|.|    :||......||..|     |::|:              |.:|.|.|.  :||..
  Rat   130 TSCASKG----KHSKVSDLISHFEG-----GSVLSSYTDVQKDSTMNLNIPQTPRQHG--LTSTT 183

  Fly   430 ADSMP--RKAWEQQSDEYDIQLDVGFIE----------QCTRRFESA-SPSPMPPAYSSGQHSPI 481
            ...:|  :...:|:.|....|...|.:.          :|....|:| ||.......::...:.:
  Rat   184 PQKLPSHKSPQKQEKDSDQNQGQHGCLANGVAAAQSQMECETEKEAALSPETDTQTAAASPDAHV 248

  Fly   482 L------LPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPA 540
            |      ..|..|.:|.:...|:..| .:.|.|             |.||.||   ||
  Rat   249 LNGVRNETTTDSASSVTNSHDENACD-SSCRTQ-------------GTDLGLP---SK------- 289

  Fly   541 DRCTPRVCEGDEVLMI------NGRDVHGL----RHEQVVAMIRDCRHQASGELLLTVRPQRSAP 595
                    ||:.|:..      ||....||    :|.:|........|:.:.|||||.|...|.
  Rat   290 --------EGEPVIEAELQERENGLSTEGLNPLDQHHEVKETNEQKLHKIATELLLTERAYVSR- 345

  Fly   596 LLLEEEPLYQYVPESDEIGS---------HSNLLDGDALFTQSLL--------------LLSDGL 637
            |.|.::..|..:.|....||         .||:...:|..::.||              .:.|.|
  Rat   346 LNLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL 410

  Fly   638 ASGALLAQYELMYR---KNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYV 699
            ..   ||.:..||.   |..|.|: |..|.......:::.::. :..:..:..|||..:
  Rat   411 QK---LAPFLKMYGEYVKGFDNAV-ELVKNMTERVPQFKSVTE-EIQKQKICGSLTLQH------ 464

  Fly   700 NMEIPGGAVNRY----------IATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQY 754
            :|..|...:.||          ::...|..:.......::...:||....:.. ||: .:|..:.
  Rat   465 HMLEPIQRIPRYEMLLKDYLKKLSPDAPDWNDAKKSLEIISTAASHSNSAIRK-MEN-LKKLLEI 527

  Fly   755 WPVTGEELQLA--------EG--FSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPD 809
            :.:.|||..:.        ||  ..:...:....|...|:|...:|
  Rat   528 YEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLL------------------- 573

  Fly   810 HCVPSDPNLFLEFTERVR----------------------AARNRTL-LQEIEESLKQ--VRLMD 849
            :|||....:..:||.|.|                      :.:.||| ||...|..|:  ::.:.
  Rat   574 YCVPRFSLVGSKFTVRTRVGIDGMKIVETHNEEYPHTFQVSGKERTLELQASSEQDKEEWIKALQ 638

  Fly   850 ADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDT 914
            ...||      ..:|.....|....|::.|:..|                :|.:|:.....:.|.
  Rat   639 ESIDA------FHQRHETFRNAIAKENDIPLEVS----------------TAELGKRAPRWIRDN 681

  Fly   915 ALAL-MEAREPVYPLDIVRTMRDQRAC 940
            .:.: |:.:|....|  .|.....|||
  Rat   682 EVTMCMKCKESFNAL--TRRRHHCRAC 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	24/96 (25%)
		Y_phosphatase	666..955	CDD:278528	53/321 (17%)
		PTPc	668..955	CDD:238006	53/319 (17%)
Fgd4	XP_038943909.1	RhoGEF	328..512	CDD:238091	40/195 (21%)
		PH1_FDG4	544..637	CDD:275434	20/111 (18%)
		FYVE_FGD1_2_4	675..739	CDD:277280	8/34 (24%)
		PH2_FGD1-4	758..860	CDD:270056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910