DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Ptpn21

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001139671.1	Gene:	Ptpn21 / 24000	MGIID:	1344406	Length:	1176	Species:	Mus musculus

Alignment Length:	1259	Identity:	306/1259 - (24%)
Similarity:	464/1259 - (36%)	Gaps:	404/1259 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GPELARDKK-TPQRQQCVT--VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQ 81
            |.:|.|.:: |...:.|:.  :..|::....|.:...:.|.|.|:.|.|.|||.|..||.|.:..
Mouse     6 GLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYN 70

  Fly    82 KPGDVVRWVDAQKQFKKQCSSVSLDNDAV-PLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNIL 145
            |... .||||.:|..|||     ||..|: |.:.|.|.|:|...|:||:|.||||:|||:|::||
Mouse    71 KQNQ-RRWVDLEKPLKKQ-----LDKHALEPTVYFGVLFYVPSVSQLQQEITRYQYYLQLKKDIL 129

  Fly   146 LGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQL-----LCDQTT--EAERKVGELHK 203
            .|.|||:......||...||::.|||:..|.| .:|....|     |.|:..  ||.:||..||:
Mouse   130 EGNLPCTLEHAIQLAGLAVQADFGDFDQYESQ-DFLQKFALLPVAWLQDEKVLEEAAQKVALLHQ 193

  Fly   204 LHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVN-TFSWSK 267
            .:||....:||..|::..:|::.||.:.:.|.||.|.::.:|....|:.|...:.|.. .|.|..
Mouse   194 KYRGLTAPEAELLYMQEVERMDGYGEESYPAKDSQGSDISIGACLDGIFVKHKNGRPPVVFRWHD 258

  Fly   268 MVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLK----------- 321
            :..:|..:..|.::|     .|.:..:.|.....:.||.:|:.||..|.|:||.
Mouse   259 IANMSHNKSFFALEL-----ANKEETIQFQTEDMETAKYVWRLCVARHKFYRLNQCSLQTQAATL 318

  Fly   322 --------------RP---------------HRLSRFL----NISLGSK--FYYSGRTELQAVQE 351
                          :|               |....|.    ||.:.:|  ||...:|.|...|.
Mouse   319 NSVRRGSSSRMSLPKPQPYAMPPPPQLHYNGHYTEPFASSQDNIFVPNKNGFYCHSQTSLDRTQI 383

  Fly   352 SKQRGRIHKVFVRS---------------PSKRLLGAAGGVGTSGSSGGT--------PMQQHS- 392
            ... |||....|.|               ||.        :.::.|..|:        |..:||
Mouse   384 DLS-GRIRNGSVYSAHSTNSLNTLQPYLQPSP--------MSSNPSITGSDVMRPDYIPSHRHSA 439

  Fly   393 ---------------------GSESANSHNNG-KPAGAGTILTITKTSRPHDNKVTSKEADSMPR 435
                                 |...|:.|::. :....|:....   |||.....:..|....|.
Mouse   440 LIPPSYRPTPDYETVMKQLNRGMVHADRHSHSLRNLNIGSSYAY---SRPDALVYSQPEIREHPH 501

  Fly   436 KAWEQQSDEYDIQLDVGFIEQC-------------------------------------TRRFES 463
            .. ..||..|...|:..|..|.                                     |:.:..
Mouse   502 LT-SPQSAHYPFNLNYSFHSQSPYPYPAERRPVVGAVSVPELTNVQLQAQDYPAPNIMRTQVYRP 565

  Fly   464 ASPSPMP-PAYSS---GQH------SPILLPTTIADAVGHQQPES---------GSDLITIRLQA 509
            ..|.|.| ||.|:   .:|      :|.|:...:..:|...|.:|         .|:.:|....|
Mouse   566 PPPYPYPRPANSTPDLSRHLYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARHA 630

  Fly   510 DEQGRYGFNVKG------GVDL---SLPVQVSKVVPHT----------------------PADRC 543
            ..|.|....:.|      |:.|   ::....:.|.|.|                      ...|.
Mouse   631 HLQKRNSIEIAGLTHGFEGLRLKERTVSASAADVAPRTFSAGSQSSVFSDKMKQEGTEEQEGGRY 695

  Fly   544 TPRVCEGDEVLMINGRD-----VHGLRHEQVVAMIRDCRHQA--SGEL----------------- 584
            :.:....|..::|:..:     ......||.::.:.:.|..|  |.||
Mouse   696 SHKKSLSDATMLIHSSEEDEDLEEDSSREQAISAVSEPRLTAAFSQELNYPCASATPITGPLHIF 760

  Fly   585 ----------------------LLTVRPQRSAPLL--LEEEPLY---QYVPESDEIGSH--SNLL 620
                                  :.|.||:|...|.  :.|..|.   :|....|.:...  |:||
Mouse   761 EPKPHVTEPEKRAKDISPVHLVVETHRPRRDGLLTPSMSESDLTTSGRYRARRDSVKKRPVSDLL 825

  Fly   621 DG--------------------------------DALFTQSLLLLSDG----------------- 636
            .|                                :.|....|.|..:|
Mouse   826 SGKKSAVEGLPPLGGMKKTRADAKKIGPLKLAALNGLSLSRLPLPDEGKEVSTRATNDERCKVLE 890

  Fly   637 --LASGALLAQYELMYRKN-PDLAITEARKPANAPKNRYRDISPYDCTRVSLV---NSLTGDYIN 695
              |..|.:..:||.:.:|. .|...:.||.|.||.:||::|:.|||..||.||   .:.|| |||
Mouse   891 QRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDARVELVPTKENNTG-YIN 954

  Fly   696 ANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWP---- 756
            |:::.:.:.|...: ||||||||.:|..|||:||.::...::.|:|...|.||:|..:|||
Mouse   955 ASHIKVSVSGIEWD-YIATQGPLQNTCQDFWQMVWEQGVAIIAMVTAEEEGGREKSFRYWPRLGS 1018

  Fly   757 ----VTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKH----EQRHIHHMQYLAWPDHCVP 813
                ||....::...|          .|.|..:....||.||    ::|.:.|:||..||:|..|
Mouse  1019 RHNTVTYGRFKITTRF----------RTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCP 1073

  Fly   814 SDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDET 878
            .|...||.:.|.:::.|..|                                     .:|.|.::
Mouse  1074 EDLKGFLSYLEEIQSVRRHT-------------------------------------NSTSEPKS 1101

  Fly   879 PVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRT---MRDQRAC 940
                  |      |||::||||||:|||||:||.:..:|.:|..|   .|||.|.   :|.||..
Mouse  1102 ------H------NPPLLVHCSAGVGRTGVVILSEIMVACLEHNE---VLDIPRVLDMLRQQRMM 1151

  Fly   941 MVQNVSQYRFVCECICAAYMKISR 964
            :||.:.||.||.. :...::|.||
Mouse  1152 LVQTLGQYTFVYR-VLIQFLKSSR 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	77/206 (37%)
		FERM_N	38..102	CDD:286467	23/63 (37%)
		FERM_M	125..232	CDD:278785	45/113 (40%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	24/94 (26%)
		FA	333..369	CDD:285894	13/52 (25%)
		PDZ_signaling	502..589	CDD:238492	21/163 (13%)
		Y_phosphatase	666..955	CDD:278528	100/306 (33%)
		PTPc	668..955	CDD:238006	98/304 (32%)
Ptpn21	NP_001139671.1	B41	24..222	CDD:214604	76/204 (37%)
		FERM_N	27..90	CDD:286467	24/68 (35%)
		FERM_M	109..220	CDD:278785	45/111 (41%)
		FERM_C_PTPN14_PTPN21	217..307	CDD:270009	25/94 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..703		2/34 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..825		7/35 (20%)
		PTPc	898..1168	CDD:214550	107/334 (32%)
		PTPc	925..1168	CDD:238006	98/307 (32%)
		Substrate binding. /evidence=ECO:0000250	1110..1116		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810