DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Farp2

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_663494.2	Gene:	Farp2 / 227377	MGIID:	2385126	Length:	1065	Species:	Mus musculus

Alignment Length:	862	Identity:	230/862 - (26%)
Similarity:	353/862 - (40%)	Gaps:	193/862 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGD 85
            ||.:...:..::...:.|..||.....|.||.:..|..||.||:::|.|.|.|||||.|......
Mouse    31 PEQSLSPRMQEKHMRIRVKLLDSTVELFDIEPKCDGQVLLTQVWKHLNLIECDYFGLEFKNVQSY 95

  Fly    86 VVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLP 150
            .: |::..|...:|   |....:||  |...||||..||.:||||:|||.|.||:||::|..:|.
Mouse    96 WI-WLEPMKPIIRQ---VRKPKNAV--LRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLT 154

  Fly   151 CSSNTQCLLASYTVQSELGDFN-ALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAE 214
            |::||..||.|:.:|||:||:: .|:.:  :|...:.|.:|....| |:.:.|:.|.||.||:::
Mouse   155 CTANTAALLISHLLQSEIGDYDETLDRE--HLKANEYLPNQEKSLE-KILDFHQRHTGQTPAESD 216

  Fly   215 YNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFF 279
            :..||.|::||:|||..|.|:|..|.::.|.||.:|:||||.:.::|||:|||:.|:|||||.|.
Mouse   217 FQVLEIARKLEMYGIRFHMASDREGTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFL 281

  Fly   280 IQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLK-RPHRLSRFLNISLGSKFYYSGR 343
            |:|..|....|...|.|.:.|....|..||.|||:|:||||. :|...::.:..|.||.|.||||
Mouse   282 IKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLSDQPKPKAKAVFFSRGSSFRYSGR 346

  Fly   344 TELQAV---------------QESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQH-- 391
            |:.|.|               :.||.|..:|.:.|..| |:.:....|:.||.|.....:..:
Mouse   347 TQKQLVDYVKDGGMKRIPYERRHSKTRTSLHALTVDLP-KQSVSFTDGLRTSASLSSANVSFYPP 410

  Fly   392 -SGSESANSHNNGKPAGAGTI---------LTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYD 446
             |.|.|.....|.|.:.:..:         ....::|.|..:...|.::..:|...        .
Mouse   411 PSSSLSPPGLPNLKDSSSSLVDPQAPVIKSTAAERSSGPSSSDGPSTQSAHLPGPP--------V 467

  Fly   447 IQLDVGFIEQCTRRFESASPSP------------MPPAYSSGQH--SPILLPTTIADAVGHQQPE 497
            ::...||      ..:|..|||            :..|.|:.:.  ||:|.|..
Mouse   468 LRPGPGF------SMDSPQPSPSSLKSHLSLCPELQAALSTAEQGASPVLSPVL----------- 515

  Fly   498 SGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADR---------CTPRVCEGD-E 552
            ||:.  |.|:...|:.::                    .|.|.|.         .|.|....| |
Mouse   516 SGAG--TARMDNQEEQKH--------------------KHMPEDEAYFIAKEILATERTYLKDLE 558

  Fly   553 VLMINGRDVHGLRHEQVVAMI---------------RDCRHQASGELLLTVRP---------QRS 593
            |:.:..|.|. ::.|.:.|.:               |...|:....|.|...|         ||.
Mouse   559 VITVWFRSVL-IKEEAMPAALMALLFSNIDPVYEFHRGFLHEVEQRLALWEGPSSAHLKGDHQRI 622

  Fly   594 APLLLEE----EPLYQYVPESDEI-------GSHSNLLDGDALFTQSLL---------------- 631
            ..:||..    :....|....||:       ..|...|  :|::.:..|
Mouse   623 GDILLRNMRQLKEFTSYFQRHDEVLTELEKATKHCKKL--EAVYKEFELQKVCYLPLNTFLLKPV 685

  Fly   632 --LLSDGLASGALLAQYELMYRKNPDL-----AITEARKPANAPKNRYRDISPYDCTRVSLVNSL 689
              |:...|....|.|.|...:|...|.     ||||..........|..::..        :..|
Mouse   686 QRLVHYRLLLSRLCAHYSPGHRDYADCHEALKAITEVTTELQQSLTRLENLQK--------LTEL 742

  Fly   690 TGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQE-----SSHLLVMLTTVMESGRQ 749
            ..|.:...  |:..||    |....:|.|...|.   :.:||.     |..||....:|..:...
Mouse   743 QRDLVGVE--NLIAPG----REFIREGCLHKLTK---KGLQQRMFFLFSDMLLYTSKSVTGASHF 798

  Fly   750 KCHQYWPVTGEELQLAE 766
            :...:.|:.|..::.:|
Mouse   799 RIRGFLPLRGMLVEESE 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	78/197 (40%)
		FERM_N	38..102	CDD:286467	23/63 (37%)
		FERM_M	125..232	CDD:278785	45/107 (42%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	44/93 (47%)
		FA	333..369	CDD:285894	17/50 (34%)
		PDZ_signaling	502..589	CDD:238492	19/111 (17%)
		Y_phosphatase	666..955	CDD:278528	19/106 (18%)
		PTPc	668..955	CDD:238006	19/104 (18%)
Farp2	NP_663494.2	B41	45..234	CDD:214604	78/197 (40%)
		FERM_N	48..111	CDD:286467	24/66 (36%)
		FERM_M	131..234	CDD:278785	45/105 (43%)
		FERM_C_FARP1-like	221..341	CDD:270014	54/119 (45%)
		FA	333..375	CDD:285894	14/41 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..489		15/96 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..534		9/62 (15%)
		RhoGEF	540..723	CDD:238091	36/185 (19%)
		PH1_FARP1-like	752..859	CDD:269928	15/71 (21%)
		PH	760..854	CDD:278594	12/59 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..902
		PH2_FARP1-like	929..1026	CDD:270055
		PH	934..1027	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910