DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Mylip

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_722484.2	Gene:	Mylip / 218203	MGIID:	2388271	Length:	445	Species:	Mus musculus

Alignment Length:	381	Identity:	107/381 - (28%)
Similarity:	180/381 - (47%)	Gaps:	50/381 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLD 106
            |.:.....:|.:|.|.:.|:||.:.|.:.|.|||||.|....|:.: |::.:.:..:|     :|
Mouse     9 DAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESL-WLNLRNRISQQ-----MD 67

  Fly   107 NDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDF 171
            ..|...|:.|||||| :|..:.:|.||:.|:|.||.::|.|.|.||......|::...|::.||:
Mouse    68 GLAPYRLKLRVKFFV-EPHLILQEQTRHIFFLHIKESLLAGHLQCSPEQAVELSALLAQTKFGDY 131

  Fly   172 NALEHQPGYLSGMQLLCDQ--TTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRA 234
            |....|..|    :.||::  ::.....:...||...|...|.|||..|:....:|.|||:.|..
Mouse   132 NQNTAQYSY----EDLCEKELSSSTLNSIVAKHKELEGISQASAEYQVLQIVSAMENYGIEWHAV 192

  Fly   235 TDSNGKELQLGVSAVGLLVFQHSLR-VNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGM 298
            .||.|::|.:||...|:.:.:.... :|..::..:...:...|:.::.:.:| |.|...|| |.|
Mouse   193 RDSEGQKLLIGVGPEGISICKEDFSPINRIAYPVVQMATQSGKNVYLTVTKE-SGNSIVLL-FKM 255

  Fly   299 SSHKHAKALWKSCVEHHSFFRLK--------------RPHRLSRFL--NISLGSKFYYSGRTELQ 347
            .|.:.|..|:::..|.|:|:|..              :.|..|.||  ||:||.|:.:..:
Mouse   256 ISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIK---- 316

  Fly   348 AVQESKQRGRIHKVFVRSPSKRLLGAAGGVG----TSGSSGGTPMQQHSGSESANS 399
              :.||:        |...::|.|..||.|.    :..|...:|::....|.|.:|
Mouse   317 --RTSKE--------VYDHARRALYNAGVVDLVSRSDQSPPSSPLKSSDSSMSCSS 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	61/191 (32%)
		FERM_N	38..102	CDD:286467	18/59 (31%)
		FERM_M	125..232	CDD:278785	33/108 (31%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	26/94 (28%)
		FA	333..369	CDD:285894	6/35 (17%)
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
Mylip	NP_722484.2	B41	5..190	CDD:214604	61/191 (32%)
		FERM_N	5..67	CDD:286467	18/63 (29%)
		FERM_M	85..190	CDD:278785	33/108 (31%)
		FERM_C_MYLIP_IDOL	185..295	CDD:270016	27/111 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..363		5/23 (22%)
		zf-C3HC4_3	383..428	CDD:290631
		Critical for homodimerization. /evidence=ECO:0000250	431..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910