DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Sntb2

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001355245.1	Gene:	Sntb2 / 20650	MGIID:	101771	Length:	531	Species:	Mus musculus

Alignment Length:	512	Identity:	102/512 - (19%)
Similarity:	166/512 - (32%)	Gaps:	201/512 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 ESASPSPMPPAYS-------SGQHSPILLPTTIADAVGHQQP-----------ESGSDLITIRLQ 508
            ::|:..|.|||.:       .|..|   ||.:....:|...|           .:...:..:|:.
Mouse    38 DAAAVEPEPPAAAFNGLPNGGGGES---LPGSPNRGLGPPSPPAPPRGPAGEASASPPVRRVRVV 99

  Fly   509 ADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMI 573
            ..|.|..|.::|||.:..:|:.:||:.|...||: :..:..||.:|.:||.|:....|:|.|..:
Mouse   100 KQEAGGLGISIKGGRENRMPILISKIFPGLAADQ-SRALRLGDAILSVNGTDLRQATHDQAVQAL 163

  Fly   574 RDCRHQASGELLLTVR------PQRSAPLLLEEEPLYQYVPE------SDEIGS----------- 615
            :    :|..|:||.|:      |....|.|:.:.|.....|:      |::.||
Mouse   164 K----RAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGASPQSPSFSGSEDSGSPKHQNTTKDRK 224

  Fly   616 ---------------------------------------------------HSNLLDGDALFTQS 629
                                                               |:|::   ||..|.
Mouse   225 VIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNIM---ALLPQV 286

  Fly   630 L-----LLLSDGLASGA--------LLAQYEL---MYRKNPDL-AITEARKPANAPKNRYRDISP 677
            |     :|.:...|.|:        |..|.:|   ..:..|.| |:||            :|:..
Mouse   287 LAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTE------------KDLLL 339

  Fly   678 YDC---TR--------------VSLVNSLTGDYINANYVNMEIPGGAVNRYIATQ-GPLASTTTD 724
            |||   ||              ..||:|.:|         ...|....:...||: |........
Mouse   340 YDCMPWTRDAWASPCHSYPLVATRLVHSGSG---------CRSPSLGSDLTFATRTGSRQGIEMH 395

  Fly   725 FWRMVQQESSHLLVMLTTVMESGRQKCH-----------QYWP----------VTGEELQLAEGF 768
            .:|:   |:...|...|.::..|   ||           .|.|          :....::.:...
Mouse   396 LFRV---ETHRDLSTWTRILVQG---CHAAAELIKEVSLDYGPAFLSKADCICIAHVLIRQSHSH 454

  Fly   769 SVRCLSEKPDETGSFVFREF-VLKD---------KHEQRHIHHMQYLAWPDHCVPSD 815
            ...|:|.|.:|....|.|.. ..||         ||:|:.:     |..|..|:|.|
Mouse   455 GTACVSSKSEERALTVTRSISTSKDEKKEKATTKKHKQKPL-----LLPPSQCLPED 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	26/86 (30%)
		Y_phosphatase	666..955	CDD:278528	39/199 (20%)
		PTPc	668..955	CDD:238006	39/197 (20%)
Sntb2	NP_001355245.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..95		9/52 (17%)
Sntb2	NP_001355245.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..220		4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910