DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and EPB41L2

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_024302117.1	Gene:	EPB41L2 / 2037	HGNCID:	3379	Length:	1079	Species:	Homo sapiens

Alignment Length:	1039	Identity:	287/1039 - (27%)
Similarity:	422/1039 - (40%)	Gaps:	267/1039 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TRTFRLRGGGP----------ELARDK------KTPQRQQCVTVLFLDDITHTFRIEKRAKGSEL 59
            |:..:|.||..          ||..:|      |..:..|| .|..||...::..:||.|||..|
Human   180 TQEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQC-KVTLLDGTEYSCDLEKHAKGQVL 243

  Fly    60 LDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDP 124
            .|:|.::|.|.|:|||||||.:.| :...|:|..|:.|:|..::..      |..|.|||:..||
Human   244 FDKVCEHLNLLEKDYFGLLFQESP-EQKNWLDPAKEIKRQLRNLPW------LFTFNVKFYPPDP 301

  Fly   125 SRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCD 189
            |:|.|:.|||...||::::|..|:||||..|..||.|||:|:||||::..||....||..|....
Human   302 SQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPT 366

  Fly   190 QTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVF 254
            ||.|.|.||.||||.|||..||.|:..:||:||||.:||:|||.|.||.|.:::|||.|.|||::
Human   367 QTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIY 431

  Fly   255 QHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFR 319
            :..||:|.|:|.|::|:|:||.:|:|::|....|.:::.:||.:.:|:.||.|||.|||||:|:|
Human   432 KDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYR 496

  Fly   320 LKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLL------------- 371
            |..|.:..:...::|||||.|||||:.|..|.|....|....|.|:.|||:.
Human   497 LVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQ 561

  Fly   372 -------GAAGGVGTSGSS--GGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTS 427
                   ||||.:...|..  ....:|...|.....|                .|..||...:..
Human   562 SLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRS----------------PTKAPHLQLIEG 610

  Fly   428 K------EADSMPRKAWEQQSDEYD-IQLDV----GFIEQCTRRFESASPSPMPPAYSSGQHSPI 481
            |      |.|::..:......:|.| .|.|:    ..|.:..|.|..::|.|.|..:...:.:|:
Human   611 KKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTPEPRPNEWEKRRITPL 675

  Fly   482 LLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPR 546
            .|.|.     |..:.|..|.|              |:.||..|       |.....|.|   |..
Human   676 SLQTQ-----GSLEEEITSIL--------------FSEKGFSD-------SMKATFTSA---TTW 711

  Fly   547 VCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPL--LLEEEPLYQYVPE 609
            ..|| .|:..|                      |..|.|      .|:|.  |||..     .||
Human   712 TAEG-AVVSAN----------------------APSEKL------SSSPFSHLLETR-----APE 742

  Fly   610 SDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRY-- 672
                                    |:|..:||    .:.:...:..|.|.|.:|.|...|:..
Human   743 ------------------------SEGPCTGA----RDAVKSSHETLNIVEEKKRAEVGKDERVI 779

  Fly   673 ------RDISP---------------YDCTRVSLVNSLT---------GDYINANYVN------- 700
                  ::|||               .|.|.:|..:|.:         |:|...:.|.
Human   780 TEEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREE 844

  Fly   701 -------MEIPGGA---VNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMES-GRQKCHQY 754
                   .|.|..|   |.|..|.  |.||..|       |..:.::.:.|.:.|: |.||
Human   845 QEYEEEVEEEPRPAAKVVEREEAV--PEASPVT-------QAGASVITVETVIQENVGAQK---- 896

  Fly   755 WPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLF 819
              :.||: .:.||...:.:.|:.:|....|..|           :.|:.....|.....|:|.:.
Human   897 --IPGEK-SVHEGALKQDMGEEAEEEPQKVNGE-----------VSHVDIDVLPQIICCSEPPVV 947

  Fly   820 LEFTERVRAARNRTLLQEIEESLKQVRLMDA------------DADADENGGLMRERKCAASNGA 872
            ......:..|..||     |.|.|:|.::..            |..|..:.|.:...:...|...
Human   948 KTEMVTISDASQRT-----EISTKEVPIVQTETKTITYESPQIDGGAGGDSGTLLTAQTITSESV 1007

  Fly   873 TPEDETPVSTSVHQCISAA--NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTM 934
            :....|.::.:|...||..  ...:::.....|.....|     |.|:.||||....:.:.|.:
Human  1008 STTTTTHITKTVKGGISETRIEKRIVITGDGDIDHDQAL-----AQAIREAREQHPDMSVTRVV 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	90/196 (46%)
		FERM_N	38..102	CDD:286467	27/63 (43%)
		FERM_M	125..232	CDD:278785	55/106 (52%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	44/93 (47%)
		FA	333..369	CDD:285894	17/35 (49%)
		PDZ_signaling	502..589	CDD:238492	16/86 (19%)
		Y_phosphatase	666..955	CDD:278528	63/333 (19%)
		PTPc	668..955	CDD:238006	63/331 (19%)
EPB41L2	XP_024302117.1	Neuromodulin_N	<9..222	CDD:331332	10/42 (24%)
		B41	220..409	CDD:214604	90/196 (46%)
		FERM_C_4_1_family	404..497	CDD:270005	44/92 (48%)
		FA	507..549	CDD:312314	19/41 (46%)
		SAB	630..673	CDD:309500	10/42 (24%)
		4_1_CTD	967..1072	CDD:310467	18/105 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910