DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and EPB41L1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_011526969.1	Gene:	EPB41L1 / 2036	HGNCID:	3378	Length:	1585	Species:	Homo sapiens

Alignment Length:	926	Identity:	261/926 - (28%)
Similarity:	381/926 - (41%)	Gaps:	229/926 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ARDKKTPQ------RQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLF--- 79
            ::.:|:||      :.....|..||...:...:||..:|..|.|.|.::|.|.|:|||||.|
Human   106 SKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDA 170

  Fly    80 -PQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRN 143
             .||     .|:|..|:.|||..|...:      ..|.|||:..||::|.|:.|||...||::.:
Human   171 DSQK-----NWLDPSKEIKKQIRSSPWN------FAFTVKFYPPDPAQLTEDITRYYLCLQLRAD 224

  Fly   144 ILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQ 208
            |:.|:||||..|..||.||.||:||||::|.||...|:|.::...:||.|.|.::.||||.:||.
Human   225 IITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGM 289

  Fly   209 LPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSF 273
            .|.:||.::||:||:|.:||:|||.|.||.|.::.|||.|.|||:::..||:|.|:|.|::|:|:
Human   290 TPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISY 354

  Fly   274 KRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSR-FLNISLGSK 337
            ||.:|:|::|....|.:::.:||.:.:|:.||.|||.|:|||:||||..|....: ||  .:|||
Human   355 KRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFL--VMGSK 417

  Fly   338 FYYSGRTELQAVQESKQRGRIHKVFVRSPSKR------LLGA-------------AGGVG----T 379
            |.|||||:.|..|.|....|....|.||.|||      |.||             ||..|    .
Human   418 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDE 482

  Fly   380 SGSSGGTPMQQHSG--------------SESANSHNN---GKPAGA-----GTILTITKTSRPHD 422
            .|.|||...:...|              .|:...|..   .||...     .:|..:.:|.:..:
Human   483 DGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPN 547

  Fly   423 NKVTSKEAD-----------------SMPRKAWEQQSDEYDIQLDV-------GFIEQCTRRFES 463
            :|:..::.|                 ..|.||.|.|..:...|.|:       ..:|..|::..:
Human   548 SKLIHRDRDWERERRLPSSPASPSPKGTPEKANESQRTQDISQRDLVPEPGAAAGLEVFTQKSLA 612

  Fly   464 ASPSP------MPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITI----------------- 505
            |||..      :...|:..:...:|..||:      ||.|..:.|..|
Human   613 ASPEGSEHWVFIEREYTRPEELGLLKVTTM------QQEERQAGLAGILANGRLSKVDVLVDKFK 671

  Fly   506 ------------RLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTP------------- 545
                        |....:||:.         ::.|.....|....|..|.:|
Human   672 VEVATEEMVGNRRANTQQQGKM---------IASPEDFESVGEEGPWIRESPGGAALASGRTLAE 727

  Fly   546 RVCEGDEVLMINGRDVHGLRHEQVVAMIRD-CRH--QASGELLLTV---------RPQRSAPLLL 598
            ::.||.|           ||.:...|.||: |..  |..|:..|..         ||........
Human   728 KLLEGSE-----------LRADTREATIRNRCMSDGQPEGQTELRKGLEEPHTCGRPTAPGTRPA 781

  Fly   599 EEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKN--------PD 655
            |.:.|   .|.||:.|..|.||  |....::...||:...:......:.|.|.:.        |.
Human   782 EVDVL---SPASDKGGLQSFLL--DPAHAEARAELSNETDTSFAERSFYLNYEEKDSEDQVLPPP 841

  Fly   656 LAITEARK------PANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIP--GGAVNRYI 712
            |   |.||      |...|:.....:.    .|||...|..    :.:..:|..|  |....:..
Human   842 L---EERKGRLDAPPGGEPRPTLNSLD----LRVSAAASSR----SKDEAHMTSPKEGAGTPKNH 895

  Fly   713 ATQG-----PLASTTTDFWR----MVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGF 768
            ...|     |...|..:.|.    .|:.|..||..  :...|.|.       ||:|:.|..||..
Human   896 GGPGDLKGSPAGQTFAEGWEDAQWGVEGEFPHLTA--SAAREEGT-------PVSGDLLGKAEES 951

  Fly   769 SVRCLSEKPDETGSFV 784
            ....|.:.|...|..|
Human   952 PTEELKKHPPHRGQGV 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	83/200 (42%)
		FERM_N	38..102	CDD:286467	26/67 (39%)
		FERM_M	125..232	CDD:278785	50/106 (47%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	44/93 (47%)
		FA	333..369	CDD:285894	17/35 (49%)
		PDZ_signaling	502..589	CDD:238492	22/140 (16%)
		Y_phosphatase	666..955	CDD:278528	28/130 (22%)
		PTPc	668..955	CDD:238006	28/128 (22%)
EPB41L1	XP_011526969.1	B41	124..313	CDD:214604	83/199 (42%)
		FERM_N	126..189	CDD:286467	26/67 (39%)
		FERM_M	208..313	CDD:278785	50/104 (48%)
		FERM_C_4_1_family	308..401	CDD:270005	44/92 (48%)
		FA	410..450	CDD:285894	20/41 (49%)
		SAB	518..>549	CDD:282265	4/30 (13%)
		4_1_CTD	<1495..1572	CDD:283537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910