DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Ptprn

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_033011.2	Gene:	Ptprn / 19275	MGIID:	102765	Length:	981	Species:	Mus musculus

Alignment Length:	875	Identity:	189/875 - (21%)
Similarity:	280/875 - (32%)	Gaps:	353/875 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 PHRLSRFLNISLGSKFYYSGRTELQAV----QESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSS 383
            |..|..:|....||:....|......|    ..||..|  ..:|.||.||.:||...|......:
Mouse   205 PALLQPYLFHQFGSRDGSRGSESSSGVVGVGHLSKAEG--PALFSRSASKAILGTHSGHSFGDLT 267

  Fly   384 GGTPMQ--QHSG--------------SESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADS 432
            |.:|.|  |.||              .......|.|..|        ..:|..|:.:|.....:.
Mouse   268 GPSPAQLFQDSGLLYMAQELPVPGRARAPRLPENGGNRA--------EDSSEGHEEEVLGGRGEK 324

  Fly   433 MPRKAWEQQSD---------EYDIQL------------------------------DVG------ 452
            .|.:|.:.:..         .|.::|                              :||
Mouse   325 SPPQAAQPELSLQRLTAVLAGYGVELRQLTPEQFSTLLTLLQLLPKGTGRNLEGAVNVGGADVKK 389

  Fly   453 FIEQCTR--RFESASPSPMPPAY--------------SSGQHSPILLPTTIADA---------VG 492
            .|:|..|  ..|:..|:|..|.|              |.|...|...|:.:..:         :|
Mouse   390 TIQQMQRGDPAEALPPTPSLPGYLTASPASSEVQQVLSPGFPEPPHTPSPLGSSSVLLEKKSPLG 454

  Fly   493 HQQPESGSDLITI------RLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCE-- 549
            ..||       |:      |..|:|   ||:.|.....|||...|              |:.|
Mouse   455 QSQP-------TVVGRPSARPSAEE---YGYIVTDQKPLSLVAGV--------------RLLEIL 495

  Fly   550 GDEVLMINGRDVH----------GLRHEQVVAMIRDCRHQA----------SG-ELLLT------ 587
            .:.|.|.:|..::          .:||.:....:.|...||          :| ::|.|
Mouse   496 AEHVHMSSGSFINISVVGPAVTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQRE 560

  Fly   588 ------------VRPQRSAPLLL--------------------------EEEPLYQYVPESDEIG 614
                        :.|.||..|.|                          ::|.|....||    |
Mouse   561 EAAEVLPRQAHGISPMRSVLLTLVALAGVAGLLVALAVALCMRHHSRQRDKERLAALGPE----G 621

  Fly   615 SHSNLLDGDALF-----------TQSLLLLSDG-------------------------------- 636
            :|     ||..|           |:||...::|
Mouse   622 AH-----GDTTFEYQDLCRQHMATKSLFNRAEGQPEPSRVSSVSSQFSDAAQASPSSHSSTPSWC 681

  Fly   637 ---------LASGALLAQYELMYRKNPDLAITE----------------ARKPANAPKNRYRDIS 676
                     :::|.::..|...:.:|.|....|                |:..:|..|||:.|..
Mouse   682 EEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCAAAQDESNIKKNRHPDFL 746

  Fly   677 PYDCTRVSL-VNS--LTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLV 738
            |||..|:.| |.|  ...|||||:.:....|  .:..||||||||:.|..|||:||.:....::|
Mouse   747 PYDHARIKLKVESSPSRSDYINASPIIEHDP--RMPAYIATQGPLSHTIADFWQMVWESGCTVIV 809

  Fly   739 MLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEK---PDETGSFVFREFVLKD--KHEQRH 798
            |||.::|.|.::|.:|||..|..|.  ..:.|..:||.   .|    |:.|.|.||:  ..|.|.
Mouse   810 MLTPLVEDGVKQCDRYWPDEGSSLY--HVYEVNLVSEHIWCED----FLVRSFYLKNLQTQETRT 868

  Fly   799 IHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRE 863
            :....:|:||....|:.....|:|..:
Mouse   869 LTQFHFLSWPAEGTPASTRPLLDFRRK-------------------------------------- 895

  Fly   864 RKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPL 928
                                |::|....:.|:|||||.|.||||..||:|..|..|  .:.|..:
Mouse   896 --------------------VNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRM--AKGVKEI 938

  Fly   929 DIVRTM---RDQRACMVQNVSQYRFVCECI 955
            ||..|:   ||||..:|::..|:.|....:
Mouse   939 DIAATLEHVRDQRPGLVRSKDQFEFALTAV 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894	11/39 (28%)
		PDZ_signaling	502..589	CDD:238492	24/133 (18%)
		Y_phosphatase	666..955	CDD:278528	90/299 (30%)
		PTPc	668..955	CDD:238006	89/297 (30%)
Ptprn	NP_033011.2	RESP18 homology domain. /evidence=ECO:0000250\|UniProtKB:Q16849	38..134
		RESP18	63..141	CDD:291609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..332		8/48 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..445		10/50 (20%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000250\|UniProtKB:Q16849	451..577		28/149 (19%)
		Receptor_IA-2	474..559	CDD:288410	19/98 (19%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000250\|UniProtKB:P80560	603..734		19/139 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..682		1/35 (3%)
		PTPc	711..970	CDD:214550	92/326 (28%)
		PTPc	738..970	CDD:238006	89/299 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910