Protein Alignment Ptpmeg and Ptpn4

DIOPT Version :10

• Sequence 1: NP_612031.3
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: NP_064317.2
• Gene: Ptpn4 / 19258
• MGIID: 1099792
• Length: 926
• Species: Mus musculus
• Alignment Length: 1009
• Identity: 418/1009 - (41%)
• Similarity: 576/1009 - (57%)
• Gaps: 147/1009 - (14%)

  Fly     1 MFERFRLNNLTRTFRLRGGGPELARDKKTPQRQQCV-TVLFLDDITHTFRIEKRAKGSELLDQVF 64
            |..|||| ...||:.:|..  |||||:   |..:.| .:|.||:....||:.|..:|..|||.||
Mouse     1 MTARFRL-PAGRTYNVRAS--ELARDR---QHTEVVCNILLLDNTVQAFRVNKHDQGQVLLDIVF 59

  Fly    65 QYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQE 129
            ::|:|:|||||||.......|..||:|..|..:||....|..|     |.||||||||||::|||
Mouse    60 KHLDLTERDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYN-----LNFRVKFFVSDPNKLQE 119

  Fly   130 EFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEA 194
            |:||||::||||::||.|:|.|..||..||||:.|||||||:|..|:..||||....:.:|..:.
Mouse   120 EYTRYQYFLQIKQDILTGRLSCPCNTAALLASFAVQSELGDYNQSENLAGYLSDYSFIPNQPQDF 184

  Fly   195 ERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLR 259
            |:::.:||:.|.|..||:||:|||..|:.|||||::.|.|.|.:..|:.:||.:.|:|::::.:|
Mouse   185 EKEIAKLHQQHVGLSPAEAEFNYLNAARTLELYGVEFHYARDQSNNEILIGVMSGGILIYKNRVR 249

  Fly   260 VNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR-- 322
            :|||.|.|:||:|||.|.||||||:|..|:.:|||||.|.:::..|.|||:|||||:||||.|
Mouse   250 MNTFLWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKTLWKACVEHHTFFRLDRPL 314

  Fly   323 PHRLSRFLN-ISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRL--------LGAAGGVG 378
            |.:.:.|.: .:|||||.|.||||:|:||..|::....:||.|||||.|        :.:...:.
Mouse   315 PPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSLS 379

  Fly   379 ---------TSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKV-----TSKE 429
                     .|.|..|||  .|..|.........:|:..|.::.......|.::.|     :|.:
Mouse   380 DDRLETQSLPSRSPPGTP--NHRNSSFTQEATRVRPSSVGHLVDHVVHMSPSEDFVSQRSPSSTQ 442

  Fly   430 ADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYS-SGQHSPILLPTTIADAVGH 493
            |:|:..::...|...                 |...|..:||..| ....:.|....:..|.|.|
Mouse   443 ANSIVLESSPSQETP-----------------EDGQPPALPPKQSKKNSWNQIHFSNSQQDLVTH 490

  Fly   494 --------QQPESGS--------DLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADR 542
                    ..||..:        :|:.|:::.||.||:|||||||.|..:||.||:|.|.||||.
Mouse   491 TNESFDVPSSPEKSTPNGGIPHDNLVLIKMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADL 555

  Fly   543 CTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLL---LEEEPLY 604
            |.||:.|||:|::|||||:....|:|||..|:....:.||||:|.|||.....::   ||.||.:
Mouse   556 CVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCEKHSGELVLLVRPNAVYDVVEEKLESEPDF 620

  Fly   605 QYVPESDEIGS-HSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAP 668
            ||:||...:.| |.:    |....:|::.|::||.:|.:|||::.:|||.|.:.::.|:.|.|..
Mouse   621 QYIPEKAPLDSVHQD----DHSLRESMIQLAEGLITGTVLAQFDQLYRKKPGMTMSCAKLPQNIS 681

  Fly   669 KNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGA-VNRYIATQGPLASTTTDFWRMVQQE 732
            |||||||||||.|||.|..:  .|||||||:|||||..: :|:|||.||||..|..|||:|..::
Mouse   682 KNRYRDISPYDATRVLLKGN--EDYINANYINMEIPSSSIINQYIACQGPLPHTCKDFWQMTWEQ 744

  Fly   733 SSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVL--KDKHE 795
            .|.::|||||.:|.||.|||||||...|..... .:.|.|.||:.:.  :::||:..|  ::|:|
Mouse   745 GSSMVVMLTTQVERGRVKCHQYWPEPSESSSYG-CYQVTCHSEEGNP--AYIFRKMTLFNQEKNE 806

  Fly   796 QRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGL 860
            .|.:..:||.|||||.||.|.:.||:|...||                           |:..|
Mouse   807 SRQLTQIQYTAWPDHGVPDDSSDFLDFVCHVR---------------------------DQRAG- 843

  Fly   861 MRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPV 925
                          ::|                |:|||||||||||||||.|:||:.|:|..:||
Mouse   844 --------------KEE----------------PIIVHCSAGIGRTGVLITMETAMCLIECNQPV 878

  Fly   926 YPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY 959
            ||||||||||||||.|:|..||||||||.|...|
Mouse   879 YPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_612031.3	B41	35..232	CDD:214604	97/197 (49%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	48/93 (52%)
		FA	333..369	CDD:462582	20/35 (57%)
		PDZ_PTPN3-4-like	500..589	CDD:467190	46/96 (48%)
		PTPc-N3_4	692..961	CDD:350389	119/271 (44%)
Ptpn4	NP_064317.2	B41	30..222	CDD:214604	97/196 (49%)
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010	48/93 (52%)
		FA	324..365	CDD:462582	22/40 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..412		7/34 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..474		10/61 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..511		2/18 (11%)
		PDZ_PTPN3-4-like	513..602	CDD:467190	46/88 (52%)
		PTP_DSP_cys	641..914	CDD:475123	149/335 (44%)