DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptpmeg and Ptpn14

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:NP_033002.2 Gene:Ptpn14 / 19250 MGIID:102467 Length:1189 Species:Mus musculus


Alignment Length:1251 Identity:293/1251 - (23%)
Similarity:459/1251 - (36%) Gaps:412/1251 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 VLFLDD--ITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQC 100
            :..||.  |..|..:|  :.|.|.|:.|.|.|||.|..||||.|..| ....|||:.:|..||. 
Mouse    25 IRLLDSNVIECTLSVE--STGQECLEAVAQRLELRETHYFGLWFLSK-SQQARWVELEKPLKKH- 85

  Fly   101 SSVSLDNDA-VPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTV 164
                ||..| .|||.|.|.|:|.:.||||:|.||||:|||:|:::|.|:|.||......||...|
Mouse    86 ----LDKFANEPLLFFGVMFYVPNVSRLQQEATRYQYYLQVKKDVLEGRLRCSLEQVIRLAGLAV 146

  Fly   165 QSELGDFNALEHQ----PGYLSGMQLLCDQTT--EAERKVGELHKLHRGQLPADAEYNYLEHAKR 223
            |::.||:|..:.|    ...|..|.|..::..  |..:||.:.||.|.|.|||:||..|:...:|
Mouse   147 QADFGDYNQFDSQEFLREYVLFPMDLAMEEAALEELTQKVAQEHKAHSGILPAEAELMYINEVER 211

  Fly   224 LELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVN----TFSWSKMVKVSFKRKDFFIQLRR 284
            |:.:|.::....||:|..:.||:..:|:.|..   ||.    .:.|:.:..|:..:....::|  
Mouse   212 LDGFGQEIFPVKDSHGNSVHLGIFFMGIFVRN---RVGRQAVIYRWNDIGSVTHSKAAILLEL-- 271

  Fly   285 EPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFR--------------LKRPHRLSRF------ 329
              .:..:|.| |.....::||.:.:.....|.|::              ::|....||.      
Mouse   272 --IDKEETAL-FHTDDIENAKYISRLFTTRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQ 333

  Fly   330 ------LNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGS------ 382
                  :::....  :||   |....|:|...|....::.||.:...|....|..|:||      
Mouse   334 PYILPPMHVQCSE--HYS---ETHTSQDSIFPGNEEALYCRSHNSLDLNYLNGTVTNGSVCSVHS 393

  Fly   383 ----------SGGTPMQQH---SGSESAN-----SHNNGKPAGAGTILTITKTSRPHDNKVTSK- 428
                      ...:|:..:   .||:...     ||.:      .||:..:....|....|..: 
Mouse   394 VNSLSCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRH------STIIVPSYRPTPDYETVMRQM 452

  Fly   429 -----EADSMPRK----------AWEQQSDEYDIQLD--------VGFIEQCTRRFESASPS--- 467
                 .|||..|.          |:.|..:....|.:        |.:..|.....:..|||   
Mouse   453 KRGLMHADSQSRSLRNLNIINTHAYNQPEELVYSQPEMRERHPYTVPYAHQGCYGHKLVSPSDQM 517

  Fly   468 -------PMPPAYSSGQHS--------------------------------PILLP---TTIADA 490
                   |:.|..||..|:                                |...|   |:..|.
Mouse   518 NPQNCAMPIKPGASSISHTVSTPELANMQLQGAQHYSTAHMLKNYLFRPPPPYPRPRPATSTPDL 582

  Fly   491 VGHQQP-ESGS--DLITIRLQADEQGRYGFNVKGGVDLSLPV------QVSKVVPHTP------- 539
            ..|:.. .|||  ||:|.::|        .:||...:.|.||      :||:.:..|.       
Mouse   583 ASHRHKYVSGSSPDLVTRKVQ--------LSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGGGGG 639

  Fly   540 ------ADRCTPRVCEGDEVLMI----------------------NGRDVHG------------- 563
                  :......:..|.|.:.:                      .|.:|||             
Mouse   640 TVNKRHSLEVMNSMVRGMEAMTLKSLNIPMARRNTLREQGPSEETGGHEVHGLPQYHHKKTFSDA 704

  Fly   564 -------------------------------------------------------------LRHE 567
                                                                         ||.:
Mouse   705 TMLIHSSESEEEEETLEAAPQVPVLREKVEYSAQLQAALARIPNRPPPEYPGPRKSVSNGALRQD 769

  Fly   568 Q-----VVAMIRDCRHQASGELLL-----------TVRPQRSAPLL-----------LEEEPLYQ 605
            |     .:|..|..||..|..|.:           ::.|..|.|.|           ::|.|:.:
Mouse   770 QGTPLPAMARCRVLRHGPSKALSVSRAEQLAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSE 834

  Fly   606 YVPESDEIGSHSNLL-----------------------------------DG--DAL---FTQSL 630
            .....|.|.....::                                   ||  ||.   ..:.|
Mouse   835 MFSLEDSIIEREMMIRNLEKQKMTGPQAQKRPLMLAALNGLSVARVSGREDGHHDATRVPIDERL 899

  Fly   631 LLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLV---NSLTGD 692
            ..|...|..|.:..:||.:..|..:...:.|..|.||.::|.|::.||:..||.|:   .:.|| 
Mouse   900 RALKKKLEDGMVFTEYEQIPNKKANGVFSTATLPENAERSRIREVVPYEENRVELIPTKENNTG- 963

  Fly   693 YINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV 757
            ||||:::.: :.||:...||||||||..|..|||:||.::..:::.|:|...|.||.|.|:|||.
Mouse   964 YINASHIKV-VVGGSEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPK 1027

  Fly   758 TGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKH----EQRHIHHMQYLAWPDHCVPSDPNL 818
            .|.:...|.....:..::...::|.:....  ||.||    ::|.:.|:||..||.|..|.|...
Mouse  1028 LGSKHSSATYGKFKVTTKFRTDSGCYATTG--LKVKHLLSGQERTVWHLQYTDWPHHGCPEDVQG 1090

  Fly   819 FLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTS 883
            ||.:.|.:::.|..|                                                .|
Mouse  1091 FLSYLEEIQSVRRHT------------------------------------------------NS 1107

  Fly   884 VHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQY 948
            |.:.|...:||::||||||:|||||:||.:..:..:|..|.|....::|.:|:||..|:|.::||
Mouse  1108 VLEGIRTRHPPIVVHCSAGVGRTGVVILSELMIYCLEHNEKVEVPTMLRFLREQRMFMIQTIAQY 1172

  Fly   949 RFVCECICAAYMKISR 964
            :||.: :...:::.||
Mouse  1173 KFVYQ-VLVQFLQNSR 1187

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604 81/202 (40%)
FERM_N 38..102 CDD:286467 26/65 (40%)
FERM_M 125..232 CDD:278785 45/112 (40%)
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010 20/111 (18%)
FA 333..369 CDD:285894 8/35 (23%)
PDZ_signaling 502..589 CDD:238492 26/217 (12%)
Y_phosphatase 666..955 CDD:278528 93/295 (32%)
PTPc 668..955 CDD:238006 91/293 (31%)
Ptpn14NP_033002.2 B41 24..220 CDD:214604 81/202 (40%)
FERM_C_PTPN14_PTPN21 215..305 CDD:270009 20/97 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..775 3/30 (10%)
PTPc-N14 898..1184 CDD:350447 102/338 (30%)
Substrate binding. /evidence=ECO:0000250 1123..1129 4/5 (80%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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