DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Ptpn13

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_035334.2	Gene:	Ptpn13 / 19249	MGIID:	103293	Length:	2451	Species:	Mus musculus

Alignment Length:	990	Identity:	227/990 - (22%)
Similarity:	330/990 - (33%)	Gaps:	374/990 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 RVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKL----------------PCSSNTQCL------ 158
            ||..|..:..|.|||.....|||..|   :.|||                .|....:|.
Mouse  1666 RVAAFPHEAPRSQEESICAMFYLPRK---IPGKLESESSHPPPLDVSPGQTCQPPAECAPSDATG 1727

  Fly   159 -----LASY--------TVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLP 210
                 |||.        |::::||  |.||             |...|.|..: .|.|..:|.|
Mouse  1728 KHFTHLASQLSKEENITTLKNDLG--NHLE-------------DSELEVELLI-TLVKSEKGSL- 1775

  Fly   211 ADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLG-----VSAVGLLVFQHSLRVNTF-SWSKMV 269
               .:...:.::.:..|..|:.:........|:.|     |:...:....|:..||.. :..|.|
Mouse  1776 ---GFTVTKGSQSIGCYVHDVIQDPAKGDGRLKAGDRLIKVNDTDVTNMTHTDAVNLLRAAPKTV 1837

  Fly   270 KVSFKRKDFFIQLRREP--------------SENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRL 320
            ::...|   .::|.|.|              .|.    |||.:|..:.:
Mouse  1838 RLVLGR---ILELPRMPVFPHLLPDITVTCHGEE----LGFSLSGGQGS---------------- 1879

  Fly   321 KRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSG---- 381
              ||.:....:|:..|.....|..:|..:        ||.|             .||.|.|
Mouse  1880 --PHGVVYISDINPRSAAAVDGSLQLLDI--------IHYV-------------NGVSTQGMTLE 1921

  Fly   382 --------------------------------------SSGGTPMQQHSGSESANSHN-----NG 403
                                                  .:.|....:.||..:....|     ||
Mouse  1922 DANRALDLSLPSVVLKVTRDGCPVVPTTRAAISAPRFTKANGLTSMEPSGQPALMPKNSFSKVNG 1986

  Fly   404 K-------PAGAGTI--------LTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDV-- 451
            :       |||.|:.        ||.||.|...|:.:...     |::|...||     .|||
Mouse  1987 EGVHEAVCPAGEGSSSQMKESAGLTETKESNSRDDDIYDD-----PQEAEVIQS-----LLDVVD 2041

  Fly   452 ----GFIEQ--CTRRFESASPSPM-----PPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITI 505
                ..:.|  .|||  :.||.|:     .|......:....||..:.::|  ...|...||.::
Mouse  2042 EEAQNLLNQRHATRR--ACSPDPLRTNGEAPEEGDTDYDGSPLPEDVPESV--SSGEGKVDLASL 2102

  Fly   506 RLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADR-CTPRVCEGDEVLMINGRDVHGLRHEQV 569
            ...:.|:              .|::...    |...| .|....:|::    :.:|...|.:|::
Mouse  2103 TAASQEE--------------KPIEEDA----TQESRNSTTETTDGED----SSKDPPFLTNEEL 2145

  Fly   570 VAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSH----SNLLDGDALFTQSL 630
            .|:                             |:.:..|.....|:.    ...|.|
Mouse  2146 AAL-----------------------------PVVRVPPSGKYTGTQLQATIRTLQG-------- 2173

  Fly   631 LLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYIN 695
             ||..|:.|..|....||   |..|..:....| .|..||||::|.|||.|||.|.:.  |.|||
Mouse  2174 -LLDQGIPSKELENLQEL---KPLDQCLIGQTK-ENRRKNRYKNILPYDTTRVPLGDE--GGYIN 2231

  Fly   696 ANYVNMEIPGGAVN-RYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWP--- 756
            |:::  .||.|... .|||.||||.:|..|||:||.:::|.::.|:|..:|..:.||.:|||
Mouse  2232 ASFI--RIPVGTQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPSIL 2294

  Fly   757 ----VTGEELQLA-------EGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDH 810
                :..|.|:||       :||.||.::.:..:||             |.|||.|:.:.|||||
Mouse  2295 GTTTMANERLRLALLRMQQLKGFIVRVMALEDIQTG-------------EVRHISHLNFTAWPDH 2346

  Fly   811 CVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPE 875
            ..||.|:..|.|...:|..|.
Mouse  2347 DTPSQPDDLLTFISYMRHIRR-------------------------------------------- 2367

  Fly   876 DETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRAC 940
                            :.|||.||||||||:|.||.:|..|.|:.........|:||.||.||..
Mouse  2368 ----------------SGPVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRHG 2416

  Fly   941 MVQNVSQYRFVCECI 955
            |||...||.|..:.|
Mouse  2417 MVQTEGQYVFCYQVI 2431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	34/150 (23%)
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785	31/141 (22%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	19/113 (17%)
		FA	333..369	CDD:285894	6/35 (17%)
		PDZ_signaling	502..589	CDD:238492	11/87 (13%)
		Y_phosphatase	666..955	CDD:278528	100/303 (33%)
		PTPc	668..955	CDD:238006	99/301 (33%)
Ptpn13	NP_035334.2	KIND	3..190	CDD:214801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..227
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..457
		B41	566..774	CDD:214604
		FERM_N	569..631	CDD:286467
		FERM_M	661..774	CDD:278785
		PH-like	770..870	CDD:302622
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..966
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1007..1063
		PDZ_signaling	1082..1166	CDD:238492
		PTN13_u3	1168..1356	CDD:293207
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1199..1356
		PDZ_signaling	1355..1439	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1441..1478
		PDZ	1488..1578	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1602..1662
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1695..1726		4/30 (13%)
		PDZ_signaling	1762..1841	CDD:238492	15/83 (18%)
		PDZ	1859..1942	CDD:214570	18/125 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1991..2024		10/32 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2051..2139		20/113 (18%)
		Neuromodulin	2067..2207	CDD:284117	33/205 (16%)
		PTPc	2181..2433	CDD:214550	108/332 (33%)
		PTPc	2207..2433	CDD:238006	100/302 (33%)
		Substrate binding. /evidence=ECO:0000250	2375..2381		5/5 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810