DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and ZK809.1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_502200.1	Gene:	ZK809.1 / 191427	WormBaseID:	WBGene00014085	Length:	428	Species:	Caenorhabditis elegans

Alignment Length:	316	Identity:	70/316 - (22%)
Similarity:	115/316 - (36%)	Gaps:	103/316 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   659 TEARKP-------ANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVNRYIATQG 716
            |||..|       :::.:||:.|...||..|: :|.....||||.:.:|  :|....:.|:....
Worm   142 TEASCPNRCKMWQSHSSRNRHTDYKCYDHNRI-IVQMCKDDYINGSKIN--VPHFTPSIYLVQLP 203

  Fly   717 PLAS--TTTDFWRMV---QQESSHLLVMLTTVMESGRQK--CHQYWPVTGEELQLAEGFSVRCLS 774
            .:.|  ...:|||:|   |.::.|::.....:......|  |.:    :|..| .|.||.|....
Worm   204 KMDSVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQE----SGAWL-YANGFFVNTRK 263

  Fly   775 -EKPDETGSFVFREFVLKDKHEQR-----HIH-HMQYLAWPDHCVPSDPNLFLEFTERVRAARNR 832
             ||.:...:.:|...:|.:.....     ::| :.:.|..||           .|..::|||.
Worm   264 VEKKENAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPD-----------RFGAQIRAAH-- 315

  Fly   833 TLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIV 897
                       |:.       .:|||                                 |.|.::
Worm   316 -----------QIA-------KNENG---------------------------------NSPTVI 329

  Fly   898 HCSAGIGRTGVLILMDTALALME-----AREPVYPLDIVRTMRDQRACMVQNVSQY 948
            ....|.||...|:    .||::|     .:||... :||||:|:||...|.:..||
Worm   330 ASVNGSGRNAALL----TLAVVEDQLTRGKEPKIS-EIVRTIREQRPQSVDSYIQY 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528	66/302 (22%)
		PTPc	668..955	CDD:238006	66/300 (22%)
ZK809.1	NP_502200.1	PTPc	146..386	CDD:214550	67/312 (21%)
ZK809.1	NP_502200.1	PTPc	159..386	CDD:304379	66/299 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910