DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and ZK484.7

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_491758.1	Gene:	ZK484.7 / 191327	WormBaseID:	WBGene00022753	Length:	344	Species:	Caenorhabditis elegans

Alignment Length:	354	Identity:	92/354 - (25%)
Similarity:	135/354 - (38%)	Gaps:	104/354 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   628 QSLLLLSDGLASG--ALLAQYELMYRKNPDLAITEARKPANA-PKNRYRDISPYDCTRVSLVNSL 689
            |.:..:.:.|..|  .|.|::..|.|.| |....:|.|.|.. .||||:|:...|..||.|....
Worm    39 QIVKFVKNALEKGPAGLRAEFAAMKRFN-DFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPW 102

  Fly   690 TGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQY 754
            ..|||:||:|:  .|... .|:|.||.||..:..|||.|..||....:.||..:||.|.:||..|
Worm   103 PHDYIHANFVS--TPSNP-RRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDY 164

  Fly   755 W-----PVTGEELQLAE-GFSVRCLSEKPDETGSFVFREFV----------------LKDKHEQR 797
            :     ||    |:..| |..:   ..|.:.||...|.:..                |..|..|.
Worm   165 FACKDKPV----LEFEEKGHKI---IVKFESTGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQY 222

  Fly   798 HIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMR 862
            |     ::.|||..||:.....:|...:.|.::.
Worm   223 H-----WIDWPDRGVPTADMAIVELLAKTRPSKG------------------------------- 251

  Fly   863 ERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYP 927
                                           |.:|||||||||||.:::::..|..:...:.:..
Worm   252 -------------------------------PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEE 285

  Fly   928 LD-IVRTMRDQRACMVQNVSQYRFVCECI 955
            .| |::.:|:||...:|...||.||.:.|
Worm   286 TDKILQKIREQRNNSIQTDQQYLFVHQVI 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528	79/312 (25%)
		PTPc	668..955	CDD:238006	79/309 (26%)
ZK484.7	NP_491758.1	Y_phosphatase	80..316	CDD:278528	80/312 (26%)
ZK484.7	NP_491758.1	PTPc	81..316	CDD:238006	80/311 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910