DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and F07C6.4

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001255674.1	Gene:	F07C6.4 / 178235	WormBaseID:	WBGene00008555	Length:	977	Species:	Caenorhabditis elegans

Alignment Length:	1059	Identity:	195/1059 - (18%)
Similarity:	346/1059 - (32%)	Gaps:	336/1059 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 IEKRAKGSELLDQVFQYLELS--ERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPL 112
            :..|....::|..|.:.::||  :..||.|.|.....: ..|:|.........:|.|.....: .
Worm    30 LHSRLSVEDVLRLVAEKVDLSFPDSQYFCLGFSDNLNN-FHWLDGSVILYDLVASTSNPKGTL-T 92

  Fly   113 LEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQ----CLLAS--------YTVQ 165
            |...|:|||.....:|...|...|:..|...:...:|..:|...    .:|.|        :|..
Worm    93 LSHHVRFFVDTIYEVQCASTAKLFFFDIHNQLARHELLVTSEDYFELVAILVSVFVPDCQEHTTA 157

  Fly   166 SELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLP-ADAEYNYLEHAKRLELYGI 229
            ..:.....:.|.| |:    ||....:|.||:|.|..:.:| :|| .....::::.|::.|.||.
Worm   158 EAISRIMPMSHPP-YI----LLKTDQSEVERRVFEKFRYYR-RLPVGTGMISFIKLAEKSESYGY 216

  Fly   230 DLHRATDSNGKELQLGVSAVGLLVFQHSLRVN------TFSWSKMVKVSFKRKDFFIQLR----R 284
            .::.|.:.|..:..|.:...|:.:::.|...|      .:.|..:..:.::.|.|.|::|    .
Worm   217 RMYEALNENNDKCILSIGYKGIYIYRRSRHQNLITPYLAYPWRVIDNLYYRDKKFSIEIREPKKN 281

  Fly   285 EPSENY--DTLL-------------------GFGMSSHKHAKAL---------------WKSCVE 313
            |.|||.  |.:|                   |...|:::..:.|               |.|.:.
Worm   282 ESSENVSDDVILINDRQLSEAFSHPTTQVSCGRRRSNNQQPRVLLFPFTCQTPLVCRTVWMSAIA 346

  Fly   314 HHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRS------PSKRLLG 372
            .|.|| |:|.         .|..|.::..|..:...||..:  :::::...|      ||...|.
Worm   347 QHRFF-LERK---------ELKKKGHHHSRNAVVDHQELTE--KLNRLTSTSSLGSSLPSLSSLH 399

  Fly   373 AAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRP------------HDNKV 425
            :...:||..|:     :...||.|:...::.||..       |:||.|            |:..:
Worm   400 SNSSIGTMPSA-----KIGDGSTSSLPMSSAKPMS-------TQTSEPQLPDVPEPNESLHNKTI 452

  Fly   426 TSKEADSMPRKAWEQQSDEYDIQL--------DVGFIEQCTRRFESASPSPMPPAYSSGQHSPIL 482
            ...:.|.......:.:..|.:::|        ||     |....:.....|:       :.:.::
Worm   453 DEFQKDQEKCDRLKARKAELEMRLRQKMQELKDV-----CVEEGDITGEMPV-------EINDVV 505

  Fly   483 LPTTIADAVGHQQPESGSDLITIR-------------LQADEQGRYGFNVKGGVDLSLPVQVSKV 534
            ||              |.|...::             ::||:..:..   :...|:.|..::...
Worm   506 LP--------------GDDFPRLKRRVGTAYSIPDELIKADKADKMS---QLETDVELHRRIVAA 553

  Fly   535 VPHTPADRCTPRVCEGDEVLMINGRDVHG--LRHEQVVAMIRDCRHQA----------------- 580
            ......|:.|.:     .|.....:|:..  ||..::...::..||.|
Worm   554 ASRLATDKNTNK-----SVRKKRQKDLQAARLRLNRLEQGLQQMRHSASKPDISSLTSDSSNSWT 613

  Fly   581 ----SGELL-------LTVRPQRSAPLL---LEEEPLYQYVPESDEIGSHSNLLD------GDAL 625
                ||.:|       ....|:.|.|.|   |::|.     .|.||     |:.|      ..|:
Worm   614 ASNSSGPMLTMAMTKSCPTTPRGSVPDLRNGLDDEK-----DEFDE-----NVEDRVSRRAPSAI 668

  Fly   626 FTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLT 690
            ...||.....|::|.:..:..:.|....|.       :|.:. |::.:..:|:|
Worm   669 SRHSLSQRYSGVSSSSTSSGSDSMGLGLPP-------RPTSR-KSQQQQTTPFD----------- 714

  Fly   691 GDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW 755
             |.:: |.:..|||          ..|.::.....:..|...|       |:...|.||.  .|.
Worm   715 -DQLD-NPMICEIP----------PPPSSAAAHPLYENVGYRS-------TSYRSSYRQA--HYP 758

  Fly   756 PVTGEELQLAEGFSVRCLSEKPDETG------------SFVFREFVLKDKHEQRHIHHMQYLAWP 808
            .:..|..|.....|...:|.....||            :..|||:...|:.:......:     |
Worm   759 TIQDEHTQRKRAQSAHSISTDNGATGRTSTYSVPLNDAAQKFREYDYDDEEDSTPTMDL-----P 818

  Fly   809 DHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLK-QVRLMDADAD---ADENGGLMRERKCAAS 869
            .|.:.                     ::.:..|:. |.....|..|   :..|||.:      :|
Worm   819 SHLIN---------------------VRRLTSSISCQAGFATASLDRRYSKLNGGRL------SS 856

  Fly   870 NGATPEDET-----------PVSTSVHQCI------SAAN-------PPV--IVHCSAGIGRTGV 908
            .|...:|..           ||:||....|      ||:.       |||  :.|...|
Worm   857 GGGGSDDVVRQNVTTRITTFPVATSAATVILSGKPYSASELPRFQPPPPVARVTHMPRG------ 915

  Fly   909 LILMDTALALMEAREPVYP 927
             .|...:.|.|.|:.|..|
Worm   916 -SLPPYSSATMGAQSPAPP 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	44/196 (22%)
		FERM_N	38..102	CDD:286467	11/53 (21%)
		FERM_M	125..232	CDD:278785	26/119 (22%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	27/139 (19%)
		FA	333..369	CDD:285894	8/41 (20%)
		PDZ_signaling	502..589	CDD:238492	16/129 (12%)
		Y_phosphatase	666..955	CDD:278528	56/304 (18%)
		PTPc	668..955	CDD:238006	56/302 (19%)
F07C6.4	NP_001255674.1	B41	18..219	CDD:214604	44/196 (22%)
		FERM_C_FRMD4A_FRMD4B	215..360	CDD:270012	29/154 (19%)
		DUF3338	416..565	CDD:371743	26/184 (14%)
		DAZAP2	900..>977	CDD:371348	11/41 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910