Protein Alignment Ptpmeg and epi-1

DIOPT Version :9

• Sequence 1: NP_001163309.2
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: NP_001294008.1
• Gene: epi-1 / 177956
• WormBaseID: WBGene00001328
• Length: 3715
• Species: Caenorhabditis elegans
• Alignment Length: 820
• Identity: 154/820 - (18%)
• Similarity: 268/820 - (32%)
• Gaps: 291/820 - (35%)

  Fly   154 NTQCLLASYTVQSELGDFN-ALEH-QPGYLSGMQLLCDQ-TTEAERKVGELHKLHRGQ------- 208
            ||||.:.:.......|... ..|| :.||.:..:..||: ..||:..:|.:..:..||
 Worm  2056 NTQCNVENGQCTCRPGATGMRCEHCEHGYWNYGEHGCDKCDCEADLSMGTVCDVRTGQCHCQEGA 2120

  Fly   209 --------LPADAEYNYLEHAKRLELYGIDL------HRATDSNGKELQLGVSAVGLLVFQHSLR 259
                    ||     :||    |:..||...      |...|.:..||::.|....:.....:..
 Worm  2121 TGSRCDQCLP-----SYL----RIPTYGCRRCDECVHHLIGDVDNLELEIDVLGTAIANISSATI 2176

  Fly   260 VNTFSWSKMVKVSFKRKDF-----FIQLRREPSENYDTLLGFGMSSHKHAKALWKSCV--EHHSF 317
            |.       .:::..:|:|     ..::..:...::..:.|.......::..:....|  :.||
 Worm  2177 VG-------ARLARNKKEFNDINEITKMLNDEENSFGNVFGDAQDILTNSTQIQNKLVRTKTHS- 2233

  Fly   318 FRLKRPHRLSRFLNISL-GSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSG 381
                 .:.:|...||:| |::|       ||.|.:..||.|   ..|||    |...|..:|:|
 Worm  2234 -----QNSVSSAKNITLNGTEF-------LQEVMKRAQRAR---QSVRS----LAEIALAIGSS- 2278

  Fly   382 SSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAW-------- 438
                        |::.|...........|::|:...|           ||..|.||.
 Worm  2279 ------------SKAVNVDPRLLKEAEETLMTLEAAS-----------ADQYPEKAQTVPGKLEE 2320

  Fly   439 -----EQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAY-SSGQHSPILLPTTIADAVGHQQPE 497
                 ::::::.|.|.:. |..|..|..|.|       || :|.|.   ||            .|
 Worm  2321 IQKKIQEETEKLDKQKET-FEAQKKRAEELA-------AYLNSAQQ---LL------------KE 2362

  Fly   498 SGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVH 562
            |.|       :||:..          :::..:|::||
 Worm  2363 SKS-------KADKSN----------NIAKMLQLTKV---------------------------- 2382

  Fly   563 GLRHEQVVAMIRDCRHQ---ASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGS-HSNLLDGD 623
                |.:||.|.|...:   |.||                    :|.:  :..||: ..||.|..
 Worm  2383 ----ENLVAAITDDLERVEAAKGE--------------------FQKL--NVAIGNITENLKDKR 2421

  Fly   624 ALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNS 688
            ...|.::..|::               .:|......||.|     |...||....|   :.|||:
 Worm  2422 EEMTHAVTTLNE---------------TRNDVAEALEAAK-----KRVRRDEKSVD---MQLVNA 2463

  Fly   689 LTGD-YINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCH 752
            ...: ::.|..:.........|...|.                 |:::....||..:::.:.:..
 Worm  2464 KAHELHLQATTLRQTFDNNKDNTDQAV-----------------EAANAFSNLTDTLKNAKAQID 2511

  Fly   753 QYWPVTGEELQLAEGFSVRCLSEK--PDETGSFV--FREFVLKD-KHEQRHIHHMQYLAWPDHCV 812
            ..:.....|...||  ||:...:|  ||||...:  ..:.|.:| |..::....::.|.
 Worm  2512 NAYEALSAEPAFAE--SVQNARDKPFPDETKEKIDALSKTVSQDLKETEKLKKQLEQLT------ 2568

  Fly   813 PSDPNLFLEFTERVRAAR----------NRTLLQEIEESLKQVRLMDADADADENGGLMRERKCA 867
                    |.:|::|..:          ::..|..|:|.:::|..:.|:.||:     :.|.:..
 Worm  2569 --------ELSEKLRKRKEAVKAGIPKYSKNTLDSIDEKVQEVEKLKAEIDAN-----IEETRAK 2620

  Fly   868 ASNGATPEDE-TPVSTSVHQCISAAN---------PPVIV 897
            .|..|...:| |..:.|..:.|..|.         .||||
 Worm  2621 ISEIAGKAEEITEKANSAMEGIRLARRNSVQLNKLAPVIV 2660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	23/101 (23%)
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785	23/101 (23%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	14/106 (13%)
		FA	333..369	CDD:285894	12/36 (33%)
		PDZ_signaling	502..589	CDD:238492	13/89 (15%)
		Y_phosphatase	666..955	CDD:278528	49/258 (19%)
		PTPc	668..955	CDD:238006	49/256 (19%)
epi-1	NP_001294008.1	LamNT	24..296	CDD:214532
		EGF_Lam	297..345	CDD:238012
		Laminin_EGF	427..474	CDD:278482
		EGF_Lam	471..520	CDD:238012
		EGF_Lam	519..564	CDD:214543
		Laminin_EGF	564..612	CDD:278482
		Laminin_EGF	610..658	CDD:278482
		Laminin_EGF	656..703	CDD:278482
		Laminin_EGF	701..753	CDD:278482
		Laminin_EGF	756..806	CDD:278482
		EGF_Lam	808..854	CDD:238012
		CBM6-CBM35-CBM36_like	855..988	CDD:271143
		EGF_Lam	1425..1468	CDD:238012
		EGF_Lam	1472..1515	CDD:238012
		Laminin_EGF	1517..1567	CDD:278482
		Laminin_EGF	1565..1613	CDD:278482
		LamB	1669..1793	CDD:214597
		EGF_Lam	1840..1883	CDD:238012
		Laminin_EGF	1891..1945	CDD:278482
		EGF_Lam	1947..1998	CDD:238012
		EGF_Lam	2001..2045	CDD:214543
		EGF_Lam	2048..2092	CDD:214543	9/35 (26%)
		EGF_Lam	2095..2140	CDD:214543	11/53 (21%)
		Tar	<2145..2378	CDD:223910	59/323 (18%)
		BAR	2289..2486	CDD:299863	57/324 (18%)
		Apolipoprotein	2289..2472	CDD:279749	56/310 (18%)
		COG1340	2414..2690	CDD:224259	58/308 (19%)
		ApoLp-III_like	2510..2635	CDD:304399	29/145 (20%)
		Laminin_II	2589..2730	CDD:283628	19/77 (25%)
		LamG	2704..2875	CDD:238058
		LamG	2909..3057	CDD:238058
		LamG	3353..3510	CDD:238058
		LamG	3532..3682	CDD:238058

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910