Protein Alignment Ptpmeg and Y69A2AR.19

DIOPT Version :9

• Sequence 1: NP_001163309.2
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: NP_500211.3
• Gene: Y69A2AR.19 / 177036
• WormBaseID: WBGene00022090
• Length: 1338
• Species: Caenorhabditis elegans
• Alignment Length: 1130
• Identity: 236/1130 - (20%)
• Similarity: 381/1130 - (33%)
• Gaps: 395/1130 - (34%)

  Fly    46 HTFRIEKRAKG-----------SELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQ 99
            :||..:..:|.           |.|||:    .:.|...:..:.|...||.:
 Worm   287 NTFNFDSLSKTADTINSTIKSCSNLLDK----SDTSWESHSAIRFKDLPGTL------------- 334

  Fly   100 CSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQ------FYLQIKRNILLGKLPCSSNT--- 155
               .:|.:....::...|.|     .:|...||.:|      ..::::|:.::  :|. |||
 Worm   335 ---ETLGSKVKEIINMDVSF-----DKLMNGFTAFQPLERLMHLVELRRSYII--VPV-SNTPDI 388

  Fly   156 ---------QCLLA------SYTVQSELGDFNA----LEHQPGYLSGMQLLCDQTTEAERKVGEL 201
                     |..||      |.|| |.|.|...    .||..|:.||              :.||
 Worm   389 TSNLKKVVEQVALAKAAGKSSMTV-SALADVGGSKPKREHSVGFQSG--------------ISEL 438

  Fly   202 HKLHRGQLP---------ADAEYNYLEHAKRLELYGIDLHRATDS----NGKELQLGVSAVGLLV 253
            .:|.:..|.         ..|:.|.|  |..|:    .|.:.||.    |.|...:..|:|...:
 Worm   439 KQLVKDVLDPWFSSLLNVTSAQQNNL--ADGLQ----SLFKTTDQLSRMNDKLKPIVSSSVQQTI 497

  Fly   254 FQHSLRVNTFSW--SKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHS 316
            ....:.||..|.  |...::|....:.....|..|.::...:   |:...||..:|..|..:...
 Worm   498 AVFQVLVNEISLLSSDSAEMSSVMAELDKCSRTLPMDDQRVV---GVELMKHINSLKLSLSQFAE 559

  Fly   317 FFRLKRPHRLSRFLN------ISLGSKFYYSG-------RTELQAVQESKQRG-----------R 357
            |       :.|..||      .|..:.:.:|.       .||::||.||.|:.           .
 Worm   560 F-------KTSTILNSLEKEITSFQNSYKFSDLQDPTATATEVKAVVESIQKSGSLEKFKQYLLL 617

  Fly   358 IHKVFVRSPSKRL----LGAAG------GVGTSGSSGGTPMQQHSGSESANSHNN---------- 402
            :.|.|.......|    ||...      |..|.|......::.|:..::....:.
 Worm   618 LQKTFADVDGNNLKTVILGGIKARITKIGDSTFGDFIKEELKVHTCLKAQEEQSRKLSQAIQATQ 682

  Fly   403 -------------GKPAGA--------GTILTITKTSRPHDNKVTS---------KEADSMPRKA 437
                         |..|.|        .||.:|.:|.:.....|::         |.:||:.:..
 Worm   683 SLRKLDEKMLEEVGSAASAVSSFAKDLATIKSIPETMKKEAKGVSTDLNGMADAKKNSDSVGQSV 747

  Fly   438 WEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDL 502
            ...|.....|:|:....|  .:.|     .|....|.....||     ....|:..|.....||:
 Worm   748 SSLQDASELIELESAIKE--LKGF-----GPEIDGYIKAVKSP-----EDRKAIETQWGNHHSDM 800

  Fly   503 ITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRD-----VH 562
            .::     |.|...  .||.||   .:.|||.  .|.:|..||         :.|.:|     ::
 Worm   801 ASL-----ESGLKA--AKGFVD---KIDVSKA--KTMSDYGTP---------LANLKDLPDVKIN 844

  Fly   563 GLRHEQVV-AMIRDC----RHQASGELLLTVRPQRS-----APLLLE---EEPLYQYVPESDE-- 612
            .|...:.: |:|:..    |.:|:.:....:...:|     |.|.|:   .:..||..|.:.:
 Worm   845 ALEKIKALDALIKALPPPKRKRATSDPKTVMEAAKSTLEKIAALDLQFSNHKTQYQQAPAAFKAF 909

  Fly   613 --------IGSHSNLLDGD---------ALFTQSLLLLSDGLASG-------------------- 640
                    :.:|||...|.         .:...|:|.|. |:|.|
 Worm   910 HDFLAKFLVTTHSNSTGGSDSGISITLIIIIVGSILALI-GVAVGIYFGVRWYEKKKAAEQMEHE 973

  Fly   641 ------------------ALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDC---TRVS 684
                              .|:|...:::.....:::.::.  |..||.:.|......|   |.|.
 Worm   974 IVVWVKAQAYKSLEAAIIVLVASLHVVWGTQTSVSVEKSN--AYLPKEKNRRPLATPCNPETAVE 1036

  Fly   685 LVNSLTGDYINANYVNMEIP--GGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESG 747
            :::..|...|:||::|.. |  .|...::|||||||.:|:.|||.|||......:|||...:|..
 Worm  1037 VMSDGTRIPIHANWINTS-PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKE 1100

  Fly   748 RQKCHQYWPV-TGEELQLAEGFSVRCLSEKP---DETGSFVFREFVLKDKHEQ---RHIHHMQYL 805
            .:|||:|:|| ||:.:.| |.:.::.::::.   |.|..   |...::|..::   |.|.|.||.
 Worm  1101 EEKCHEYFPVRTGQIVDL-ERYKLKTVTQEQILGDSTSK---RTIQVEDTSKEFPTRTITHYQYH 1161

  Fly   806 AWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASN 870
            :|||..:|..            .|:...|:...:||.|
 Worm  1162 SWPDQGIPQG------------HAQCFDLMNMAKESKK--------------------------- 1187

  Fly   871 GATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLI---------LMDTALALMEAREPVY 926
                                   |::||||||||||...|         |.:..|.|.:|
 Worm  1188 -----------------------PIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQA----- 1224

  Fly   927 PLDIVRTMRDQRACMVQNVSQYRFV 951
                |..:||||.|.:|.|.|..:|
 Worm  1225 ----VAELRDQRWCAIQTVEQMYWV 1245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	46/233 (20%)
		FERM_N	38..102	CDD:286467	11/66 (17%)
		FERM_M	125..232	CDD:278785	32/143 (22%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	20/99 (20%)
		FA	333..369	CDD:285894	11/53 (21%)
		PDZ_signaling	502..589	CDD:238492	20/96 (21%)
		Y_phosphatase	666..955	CDD:278528	85/307 (28%)
		PTPc	668..955	CDD:238006	85/305 (28%)
Y69A2AR.19	NP_500211.3	WSN	172..234	CDD:280385
		Y_phosphatase	1018..1245	CDD:278528	83/302 (27%)
		PTPc	1019..1245	CDD:238006	82/301 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910