DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and frm-5.1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001255216.1	Gene:	frm-5.1 / 176822	WormBaseID:	WBGene00001492	Length:	1565	Species:	Caenorhabditis elegans

Alignment Length:	1091	Identity:	196/1091 - (17%)
Similarity:	342/1091 - (31%)	Gaps:	388/1091 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NLTRTFRLRGGGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVF----QYLEL 69
            :|||...:|...|...:.:.:..|.:...|:.  ::.:..::|...:...:...||    |.:.:
Worm   658 DLTRHQNIRLRAPATKKKRISLHRVEDTEVVV--ELLNGQKVEVACRSDVISRDVFSLIVQNMNI 720

  Fly    70 SERDYFGLLFPQKPGDVVRWVDAQKQFKKQCS---SVSLDNDAVP-LLEFRVKFFVSDPSRLQEE 130
            :|..:|||.| .:.|:.....|.|:..|...|   ||:.....|| :|..|.||:......::.:
Worm   721 NEHVFFGLSF-LRDGEHYFIEDHQRLEKFAPSGWKSVARVGVKVPYVLHLRFKFYPQILDFIKTD 784

  Fly   131 FTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELG--------DFNALEHQPGYLSGMQLL 187
            .|..:.|||.:|::|..::....:....||:..:|:|.|        |:..::|   ||......
Worm   785 VTMNELYLQCRRDVLEERIQPKRDAAFELAALALQAEFGNRPPPVITDYFDIQH---YLPKKYSS 846

  Fly   188 CDQTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRA--------------TDSN 238
            .:..:..:..:.|||..:.|...::|::.|::..:|...:|..:||.              ....
Worm   847 FEDQSRLKNILAELHGHYAGTRISEAKHKYIQICQRHPDFGAHVHRVFRTKPTSAHGASPFDPDT 911

  Fly   239 GKELQLGVSAVGLLVFQ---HSLRVNTFS---------------WSKMVKVSFKRKDFFIQLRRE 285
            |..|.:|:...|:.:::   |.:.....|               |.:...:.|.:|.|.|.....
Worm   912 GSSLWIGIMPRGISIYEQQNHHIPNKYMSIARQGGAREVIAEHVWPQTQTLQFDKKRFVIVAVGA 976

  Fly   286 PSENYDT------------LLGFGMSSHKHAKAL--WKSCVEHHSFFRLKRPHRLSRFLNISLGS 336
            ..|..::            .:.|..|.|:....:  |||.:.|.:              .|....
Worm   977 HDEQIESTFYTDHHSKSSYFVRFAASQHRWMMKMRQWKSTLRHEN--------------TIQAMP 1027

  Fly   337 KFYYSGRT-----ELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSES 396
            .....|:|     ..|.::||            .||..||.:|..:
Worm  1028 DVIVEGQTIPPAPIRQGLEES------------PPSTPLLASADQI------------------- 1061

  Fly   397 ANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFI-EQCTRR 460
                             ..|.|...:....::.|:..|.....:.:.:|| .:|.|.: :.....
Worm  1062 -----------------FAKMSVSQEKPAANRPAELPPPAPSSKFAAQYD-TVDEGIVCDSQAEN 1108

  Fly   461 FESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPE---SGSDLITIRLQADEQGRYGFNVKGG 522
            ||....:........|....|||....|:.:|....:   :|...:.::|.||.    |..:|.|
Worm  1109 FERVDSTDNGNVTPRGMQFDILLVKDPANGLGLTLVDGNLNGVPGVYVKLVADN----GAGMKAG 1169

  Fly   523 VDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDC----------- 576
                                    ||.||.::.:....:.|......|.::|.|
Worm  1170 ------------------------VCVGDRIVQVGTESMEGHDRLHAVELVRRCGQRVPMVIARL 1210

  Fly   577 ----RHQ--ASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSD 635
                |||  .|.|:|.:...::|                                ||.|
Worm  1211 DGLIRHQKDVSAEMLASAGRKKS--------------------------------FTSS------ 1237

  Fly   636 GLASGALLAQYELMYRKNPDLAITEAR---KPANAPKNRYRDISPYDCTRVSLVNSLTGDYINAN 697
               ||.||        ..|:....::|   .|..|...|.|.:|.:.....:| .:|.||    |
Worm  1238 ---SGDLL--------NAPNRTNGQSRTPPAPRKAANRRQRAVSDFGAIGDAL-PTLDGD----N 1286

  Fly   698 YVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTG--- 759
            .:|::...|.                           ||       .||..:|.....|.|.
Worm  1287 LINIKAISGL---------------------------HL-------DESDEEKGEYRLPTTSMYA 1317

  Fly   760 ----EELQLAEGFSVRCLSEKP-DETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLF 819
                ::||.    |:: .|:|| .|..|...|::
Worm  1318 FDRDDDLQA----SIK-ESKKPAPEPKSGELRKY------------------------------- 1346

  Fly   820 LEFTERVRAAR--NRTLLQEIEESLKQ-----------VRLMDADADADENGGL------MRERK 865
                   |.||  |..:.:||||...:           .|::|.:.|.:|||.|      :..|.
Worm  1347 -------RYARRSNLEIAEEIEEEAVESSDDDGQIDEGKRVIDVELDRNENGSLGVQIASLSGRV 1404

  Fly   866 CAASNGATPEDETP---------------VSTSVHQ-------------CISAANPPVIV---HC 899
            |.....:.|....|               |...|||             .:....||...   |.
Worm  1405 CIKQLTSEPAISHPDIRVGDVLLYVNGIAVEGKVHQEVVAMLRGGGDRVVLGVQRPPPAYSDQHH 1469

  Fly   900 SAGIGRTGVLILMDTALALMEAREPVYPLDI---VRTMRDQRACMVQNVSQ 947
            ::....:..||      ::|..::|:..|.:   .|||.|  ...::|::|
Worm  1470 ASSTSASAPLI------SVMLLKKPMATLGLSLAKRTMSD--GIFIRNIAQ 1512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	46/212 (22%)
		FERM_N	38..102	CDD:286467	15/70 (21%)
		FERM_M	125..232	CDD:278785	23/114 (20%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	22/139 (16%)
		FA	333..369	CDD:285894	7/40 (18%)
		PDZ_signaling	502..589	CDD:238492	20/103 (19%)
		Y_phosphatase	666..955	CDD:278528	64/343 (19%)
		PTPc	668..955	CDD:238006	63/341 (18%)
frm-5.1	NP_001255216.1	PKc_like	9..164	CDD:304357
		B41	686..891	CDD:214604	46/210 (22%)
		FERM_N	689..751	CDD:286467	13/64 (20%)
		FERM_M	781..891	CDD:278785	23/112 (21%)
		PH-like	887..1016	CDD:302622	20/128 (16%)
		PDZ_signaling	1127..1208	CDD:238492	20/108 (19%)
		PDZ_signaling	1380..1458	CDD:238492	14/77 (18%)
		PDZ_signaling	1479..1559	CDD:238492	11/42 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910