Protein Alignment Ptpmeg and frm-5.2

DIOPT Version :9

• Sequence 1: NP_001163309.2
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: NP_001360605.1
• Gene: frm-5.2 / 176821
• WormBaseID: WBGene00021406
• Length: 1386
• Species: Caenorhabditis elegans
• Alignment Length: 1091
• Identity: 197/1091 - (18%)
• Similarity: 340/1091 - (31%)
• Gaps: 388/1091 - (35%)

  Fly     9 NLTRTFRLRGGGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVF----QYLEL 69
            :|||...:|...|  |..||.....:......:.::.:..::|...:...:...||    |.:.:
 Worm   479 DLTRHQNIRLRAP--ATKKKRISLHRVEDTEAVVELLNGQKVEVACRSDVISRDVFSLIVQNMNI 541

  Fly    70 SERDYFGLLFPQKPGDVVRWVDAQKQFKKQCS---SVSLDNDAVP-LLEFRVKFFVSDPSRLQEE 130
            :|..:|||.| .:.|:.....|.|:..|...|   ||:.....|| :|..|.||:......::.:
 Worm   542 NEHVFFGLSF-LRDGEHYFIEDHQRLEKFAPSGWKSVARVGVKVPYVLHLRFKFYPQILDFIKTD 605

  Fly   131 FTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELG--------DFNALEHQPGYLSGMQLL 187
            .|..:.|||.:|::|..::....:....||:..:|:|.|        |:..::|   ||......
 Worm   606 VTMNELYLQCRRDVLEERIQPKRDAAFELAALALQAEFGNRPPPVITDYFDIQH---YLPKKYSS 667

  Fly   188 CDQTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRA--------------TDSN 238
            .:..:..:..:.|||..:.|...::|::.|::..:|...:|..:||.              ....
 Worm   668 FEDQSRLKNILAELHGHYAGTRISEAKHKYIQICQRHPDFGAHVHRVFRTKPTSAHGASPFDPDT 732

  Fly   239 GKELQLGVSAVGLLVFQ---HSLRVNTFS---------------WSKMVKVSFKRKDFFIQLRRE 285
            |..|.:|:...|:.:::   |.:.....|               |.:...:.|.:|.|.|.....
 Worm   733 GSSLWIGIMPRGISIYEQQNHHIPNKYMSIARQGGAREVIAEHVWPQTQTLQFDKKRFVIVAVGA 797

  Fly   286 PSENYDT------------LLGFGMSSHKHAKAL--WKSCVEHHSFFRLKRPHRLSRFLNISLGS 336
            ..|..::            .:.|..|.|:....:  |||.:.|.:              .|....
 Worm   798 HDEQIESTFYTDHHSKSSYFVRFAASQHRWMMKMRQWKSTLRHEN--------------TIQAMP 848

  Fly   337 KFYYSGRT-----ELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSES 396
            .....|:|     ..|.::||            .||..||.:|..:
 Worm   849 DVIVEGQTIPPAPIRQGLEES------------PPSTPLLASADQI------------------- 882

  Fly   397 ANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFI-EQCTRR 460
                             ..|.|...:....::.|:..|.....:.:.:|| .:|.|.: :.....
 Worm   883 -----------------FAKMSVSQEKPAANRPAELPPPAPSSKFAAQYD-TVDEGIVCDSQAEN 929

  Fly   461 FESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPE---SGSDLITIRLQADEQGRYGFNVKGG 522
            ||....:........|....|||....|:.:|....:   :|...:.::|.||.    |..:|.|
 Worm   930 FERVDSTDNGNVTPRGMQFDILLVKDPANGLGLTLVDGNLNGVPGVYVKLVADN----GAGMKAG 990

  Fly   523 VDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDC----------- 576
                                    ||.||.::.:....:.|......|.::|.|
 Worm   991 ------------------------VCVGDRIVQVGTESMEGHDRLHAVELVRRCGQRVPMVIARL 1031

  Fly   577 ----RHQ--ASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSD 635
                |||  .|.|:|.:...::|                                ||.|
 Worm  1032 DGLIRHQKDVSAEMLASAGRKKS--------------------------------FTSS------ 1058

  Fly   636 GLASGALLAQYELMYRKNPDLAITEAR---KPANAPKNRYRDISPYDCTRVSLVNSLTGDYINAN 697
               ||.||        ..|:....::|   .|..|...|.|.:|.:.....:| .:|.||    |
 Worm  1059 ---SGDLL--------NAPNRTNGQSRTPPAPRKAANRRQRAVSDFGAIGDAL-PTLDGD----N 1107

  Fly   698 YVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTG--- 759
            .:|::...|.                           ||       .||..:|.....|.|.
 Worm  1108 LINIKAISGL---------------------------HL-------DESDEEKGEYRLPTTSMYA 1138

  Fly   760 ----EELQLAEGFSVRCLSEKP-DETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLF 819
                ::||.    |:: .|:|| .|..|...|::
 Worm  1139 FDRDDDLQA----SIK-ESKKPAPEPKSGELRKY------------------------------- 1167

  Fly   820 LEFTERVRAAR--NRTLLQEIEESLKQ-----------VRLMDADADADENGGL------MRERK 865
                   |.||  |..:.:||||...:           .|::|.:.|.:|||.|      :..|.
 Worm  1168 -------RYARRSNLEIAEEIEEEAVESSDDDGQIDEGKRVIDVELDRNENGSLGVQIASLSGRV 1225

  Fly   866 CAASNGATPEDETP---------------VSTSVHQ-------------CISAANPPVIV---HC 899
            |.....:.|....|               |...|||             .:....||...   |.
 Worm  1226 CIKQLTSEPAISHPDIRVGDVLLYVNGIAVEGKVHQEVVAMLRGGGDRVVLGVQRPPPAYSDQHH 1290

  Fly   900 SAGIGRTGVLILMDTALALMEAREPVYPLDI---VRTMRDQRACMVQNVSQ 947
            ::....:..||      ::|..::|:..|.:   .|||.|  ...::|::|
 Worm  1291 ASSTSASAPLI------SVMLLKKPMATLGLSLAKRTMSD--GIFIRNIAQ 1333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	45/212 (21%)
		FERM_N	38..102	CDD:286467	14/70 (20%)
		FERM_M	125..232	CDD:278785	23/114 (20%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	22/139 (16%)
		FA	333..369	CDD:285894	7/40 (18%)
		PDZ_signaling	502..589	CDD:238492	20/103 (19%)
		Y_phosphatase	666..955	CDD:278528	64/343 (19%)
		PTPc	668..955	CDD:238006	63/341 (18%)
frm-5.2	NP_001360605.1	B41	510..712	CDD:214604	45/205 (22%)
		PH-like	708..837	CDD:388408	20/128 (16%)
		PDZ_signaling	948..1029	CDD:238492	20/108 (19%)
		PDZ_signaling	1201..1279	CDD:238492	14/77 (18%)
		PDZ_signaling	1300..1380	CDD:238492	11/42 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910