DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and nfm-1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_498336.1	Gene:	nfm-1 / 175870	WormBaseID:	WBGene00003593	Length:	709	Species:	Caenorhabditis elegans

Alignment Length:	750	Identity:	163/750 - (21%)
Similarity:	264/750 - (35%)	Gaps:	215/750 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 IEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLD-NDAVPLL 113
            |||...|..|.:.|.:.:.|.|..||||.|..|. ::..|:...|....|  .:..| :|.....
Worm    30 IEKTWTGRHLFEAVCRIIGLRETWYFGLQFTNKK-NIPCWLQNDKTICGQ--DIQKDTSDGTFNF 91

  Fly   114 EFRVKFFVSDPSRLQEEF----TRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQS-------E 167
            .|.|||:   |..::.|.    ||:.|:|||:..||...|.||.....||||:.||:       |
Worm    92 LFLVKFY---PEDVEPEIILDATRHLFFLQIREAILSMNLYCSPEASVLLASFAVQAMHGDCTEE 153

  Fly   168 LGDFNALEHQPGYLSGMQLLCDQTTEAER-KVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDL 231
            :|..:..:|.|..:....   |.:.:..| ::......:.||...:||..||..|:.||:|||..
Worm   154 VGPIDLDKHLPKSVIDQY---DMSADMWRDRIKRWWSRNAGQSREEAELEYLRVAQDLEMYGILY 215

  Fly   232 HRATDSNGKELQLGVSAVGLLVFQHSLRVNT---FSWSKMVKVSFKRKDFFIQLRREPSENYDTL 293
            :...::...:|.||:||.||.:::...|:..   ||||::..:.||.:.|
Worm   216 YPICNNKETDLHLGISAQGLGIYKGVNRITPRPFFSWSEIKNIQFKNRKF--------------- 265

  Fly   294 LGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGR-----TELQAVQ--- 350
                     |.|.:.||.:.    ||.:.....|..|::.:|:...|..|     .|:|.::
Worm   266 ---------HMKTVDKSTIS----FRSRETSIDSSILDLCIGTHNLYLRRRQPDTLEVQQMRSQA 317

  Fly   351 ----------------ESKQRGRIHKVFVRSPSK------RLLGAAGGVGTSGSSGG--TPMQQH 391
                            |.|:|.::.|.:.....|      .|:.|...:..:..:..  ....:|
Worm   318 KEDKQRRAAEQAKVALERKERQQMEKEYKEMKQKVEVMTLELMKAQENIRKAEEANDQLAEKARH 382

  Fly   392 SGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEA-DSMPRKAWE---------------- 439
            |..|:...:.......|       :.:|...|.:.|:|| ..|.|||.|
Worm   383 SEHETLMLYKQKSEVEA-------ECNRLSMNNMKSEEALLRMERKAREAEILAKQMSMSLADVS 440

  Fly   440 --------QQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQ------------------- 477
                    |.|.:..:.:|..:.:|.:.. :|..|. ||...|..|
Worm   441 LDANRKMTQYSSQSALIIDPNWHQQVSGH-QSGHPG-MPSTGSFHQLQSLDTHTHPQQMMSRSLN 503

  Fly   478 --HSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVK-----GGVDLSLPVQVSKVV 535
              .|....|......:.||||:..|.    ..||.:|.....|..     ||..:.:|
Worm   504 MPSSAFSSPIPSNQPLSHQQPQQMSQ----NTQAHQQQTQVQNQNQPPYYGGSGMIIP------- 557

  Fly   536 PHTPADRCTPRVCEGDEVLM----------------------INGRDVHGLRHEQVVAMIRDCRH 578
               |.|....::.|....||                      :.| |:.||:.:..|...:...|
Worm   558 ---PPDPSISQIFEQQTTLMELEKSRSEYETRARIFKEHLEELRG-DIDGLKRDGNVQNGQHREH 618

  Fly   579 QA--------SGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSD 635
            .|        ..:...|:|.::|              ..:..||| |...|...|.|.:..:...
Worm   619 DAVHAQNVAHGFDKFTTMRMKKS--------------KSASSIGS-SGSSDSLELNTVARHVAGR 668

  Fly   636 GL---------ASGALLAQYELMYRKNP-DLAITE 660
            |:         :|.::|:...:::|:.. ||..||
Worm   669 GIPRVSTVSTTSSSSILSHVMMLHRQQSYDLGNTE 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	60/194 (31%)
		FERM_N	38..102	CDD:286467	17/51 (33%)
		FERM_M	125..232	CDD:278785	36/118 (31%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	23/96 (24%)
		FA	333..369	CDD:285894	10/65 (15%)
		PDZ_signaling	502..589	CDD:238492	20/121 (17%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
nfm-1	NP_498336.1	B41	16..216	CDD:214604	60/194 (31%)
		FERM_C_ERM	210..304	CDD:270015	29/121 (24%)
		G_path_suppress	320..>526	CDD:374274	37/214 (17%)
		ERM	339..>432	CDD:366293	18/99 (18%)
		Med15	<464..>608	CDD:312941	30/160 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910