Protein Alignment Ptpmeg and frm-2

DIOPT Version :9

• Sequence 1: NP_001163309.2
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: NP_001040870.1
• Gene: frm-2 / 175848
• WormBaseID: WBGene00001489
• Length: 589
• Species: Caenorhabditis elegans
• Alignment Length: 570
• Identity: 167/570 - (29%)
• Similarity: 266/570 - (46%)
• Gaps: 84/570 - (14%)

  Fly    13 TFRLRGGGPELARDKKTPQRQ-------------QCVTVLFLDDITHTFRIEKRAKGSELLDQVF 64
            ::.||......:|:::..|:.             || .||.||.......:.:.|.||||.::||
 Worm    18 SWMLRSLSARFSRNRQQQQKSQTQDASFDTKKFVQC-KVLLLDGAHLNIVVPRNAVGSELYEEVF 81

  Fly    65 QYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPL-LEFRVKFFVSDP-SRL 127
            ..|:|.|||||||.:.. |.:|..|:|..|:..||.:.      ..|. |.||||||.|:| |.|
 Worm    82 YSLDLEERDYFGLQYTD-PFNVQHWLDPTKKVAKQVAI------GPPFTLRFRVKFFTSEPSSNL 139

  Fly   128 QEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTT 192
            :||.|||||:||||::|..|:|.|.......||::.:||||||:|...|...::|..:...:|..
 Worm   140 KEELTRYQFFLQIKQDISSGRLQCPHQLAIELAAFALQSELGDYNPELHTALFISEFRFHPEQDE 204

  Fly   193 EAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHS 257
            :.|.::.|.:|..|||.||.||.|||..|:.:|:||:|:|.....:|...:||::..|:|||...
 Worm   205 KMEVEILERYKACRGQTPAQAELNYLNKARWIEMYGVDMHIVEGKDGNTYRLGLTPQGMLVFDGP 269

  Fly   258 LRVNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLG-----FGMSSHKHAKALWKSCVEHHSF 317
            .::..|.|.|:.|:.||.|...:.:..:..::.:..:.     |.::|.|.||..||..:|.|:|
 Worm   270 QKIGLFLWEKLQKLDFKNKKITLVVEEDADQSNNGQIQLHTFVFHLTSEKAAKHFWKCAIEQHAF 334

  Fly   318 FRLK-RPHRLSRFLN-ISLGSKFYYSGRTELQAVQESKQRGRIHK----VFVRSPSKRLLGAAGG 376
            |||| ||.:.:|.:. ..|||.|.|.||||.:.:.  |:..|:.:    .|.|.||:| .|....
 Worm   335 FRLKSRPIQANRKIQFFRLGSTFKYRGRTEYETIH--KEGARLSRRQSCSFERRPSQR-YGPRQS 396

  Fly   377 VGTSGSSGGTP--------MQQHSGSESANSHNNGKPAGAGTIL------TITKTSRPHDNK--- 424
            ..|:.......        ::|...::...:|....|....:|:      |.....:|.:|.
 Worm   397 HVTNAQIRDAKRAEMRQQIIEQQRANDQQRTHAKSDPTSPHSIIQNVPLPTSPDLKKPVNNSNPF 461

  Fly   425 ----VTSKEADSMPRKAWEQQSDEYDI----QLDVGFIEQCTRRFESASPS-----PMPPAYSSG 476
                :|...:.|         |..:::    ::.||.|........||:||     |:....:|.
 Worm   462 ISDPLTPSSSSS---------SSSHNLSHVTKITVGTIGNLDTPSSSAAPSSYIPRPVVSTSTSF 517

  Fly   477 QHSPIL--------LPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFN 518
            .|.|.|        :|...:.:...:..:.....:.::.|.:|..:|..|
 Worm   518 SHPPPLPAHQSNSKIPRMSSASEQRKSSQPPQPAVRMQTQFEEPRKYSQN 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	85/198 (43%)
		FERM_N	38..102	CDD:286467	27/63 (43%)
		FERM_M	125..232	CDD:278785	47/106 (44%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	29/98 (30%)
		FA	333..369	CDD:285894	15/39 (38%)
		PDZ_signaling	502..589	CDD:238492	4/17 (24%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
frm-2	NP_001040870.1	B41	53..244	CDD:214604	85/198 (43%)
		FERM_C_NBL4_NBL5	240..336	CDD:270007	27/95 (28%)
		FA	349..393	CDD:370090	16/46 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910