DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Mpdz

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001292213.1	Gene:	Mpdz / 17475	MGIID:	1343489	Length:	2069	Species:	Mus musculus

Alignment Length:	535	Identity:	117/535 - (21%)
Similarity:	190/535 - (35%)	Gaps:	143/535 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 ELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTS---------GSSGGTPMQQHSGSESANSH 400
            ||..:.::..:||..::|     :.|....||:|.|         |..|....:...||.   :|
Mouse   122 ELDQLIKNMAQGRHVEIF-----ELLKPPCGGLGFSVVGLRSENRGELGIFVQEIQEGSV---AH 178

  Fly   401 NNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESAS 465
            .:|:......||.|  ..:..|..:|.::|.|:.:||.:      .:||.:             :
Mouse   179 RDGRLKETDQILAI--NGQVLDQTITHQQAISILQKAKD------TVQLVI-------------A 222

  Fly   466 PSPMPPAYSSG-QHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPV 529
            ...:||..|.. ..||....|..|    |..|.....:.||.|..|..| .||.:.||  .:..|
Mouse   223 RGSLPPVSSPRISRSPSAASTISA----HSNPMHWQHVETIELVNDGSG-LGFGIIGG--KATGV 280

  Fly   530 QVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSA 594
            .|..::|...||: ..|:|.||.:|.|...|:.|:..|||..::|.|.::.  :|::.    |.|
Mouse   281 IVKTILPGGVADQ-HGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRV--KLMIA----RGA 338

  Fly   595 PLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAIT 659
               :||      .|.|..:|                :.||...:|                  .:
Mouse   339 ---VEE------TPASSSLG----------------ITLSSSTSS------------------TS 360

  Fly   660 EARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTD 724
            |.|..|:..||...:....:.|:            |...:.:.|.|...::.:...|....:.|
Mouse   361 EMRVDASTQKNDESETFDVELTK------------NVQGLGITIAGYIGDKKLEPSGIFVKSIT- 412

  Fly   725 FWRMVQQESSHLLVMLTTVMESGR-QKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREF 788
                   :||       .|...|| |...|...|.|..||   ||:.:...|....||..|....
Mouse   413 -------KSS-------AVEHDGRIQIGDQIIAVDGTNLQ---GFTNQQAVEVLRHTGQTVRLTL 460

  Fly   789 VLKDKHEQRHIHHMQYLAW-----PDHCVPSDPNLFLEFTERVRAARNRTLLQEIEES--LKQVR 846
            :.|...::..:......|.     .::|...:.:|.|:        ||.::|...||.  |....
Mouse   461 MRKGASQEAELTSRGDTAKDVDLPAENCEKDEESLSLK--------RNTSILPIEEEGFPLLSAE 517

  Fly   847 LMDADADADENGGLM 861
            |.:|: |..:...|:
Mouse   518 LEEAE-DVQQEAALL 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894	5/23 (22%)
		PDZ_signaling	502..589	CDD:238492	28/86 (33%)
		Y_phosphatase	666..955	CDD:278528	40/204 (20%)
		PTPc	668..955	CDD:238006	40/202 (20%)
Mpdz	NP_001292213.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492	22/105 (21%)
		PDZ_signaling	256..335	CDD:238492	28/84 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..372		8/57 (14%)
		PDZ	375..464	CDD:214570	23/118 (19%)
		PDZ_signaling	553..622	CDD:238492
		PDZ_signaling	694..777	CDD:238492
		PDZ_signaling	994..1064	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1144
		PDZ_signaling	1151..1242	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1313
		PDZ	1349..1434	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1449..1473
		PDZ_signaling	1483..1563	CDD:238492
		MPDZ_u10	1564..1625	CDD:293272
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1571..1611
		PDZ	1626..1710	CDD:214570
		PDZ_signaling	1722..1802	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1809..1848
		PDZ_signaling	1859..1944	CDD:238492
		PDZ_signaling	1985..2068	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910