DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptpmeg and ptp-3

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:NP_001263671.1 Gene:ptp-3 / 174685 WormBaseID:WBGene00004215 Length:2248 Species:Caenorhabditis elegans


Alignment Length:1089 Identity:238/1089 - (21%)
Similarity:346/1089 - (31%) Gaps:448/1089 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 RIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPG---DVVRWVDAQKQFKKQCSSVSLDNDAV 110
            |:|..:..:.::...|   |..:.|.|.:.:..:||   |..:|        ||...||:|.:  
 Worm  1131 RVEATSNSTAVVQWDF---ESQKADSFVVKYMHEPGNRMDTEKW--------KQLPVVSIDKE-- 1182

  Fly   111 PLLEFRVKFFVSDPSR--LQEEFTRYQFY----LQIKRNILLGKLPCSSNTQCLLASYTVQSELG 169
                        :|.|  :..:...::.|    |.:|.|   .:.|| |:...:|.|.|      
 Worm  1183 ------------NPKRFAVVSDLNAHKPYAFCVLAVKNN---RQGPC-SDPPTVLESVT------ 1225

  Fly   170 DFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHR--GQLPADAEYNYLEHAKRLELYGIDLH 232
                    |.|:                |..|..|.:  ..:....|||                
 Worm  1226 --------PTYM----------------VQNLRVLWKTSNSVQLTWEYN---------------- 1250

  Fly   233 RATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFG 297
                        |...||..| .|:                .|||:   :..|..|...:..|||
 Worm  1251 ------------GPRNVGFYV-NHT----------------GRKDY---VNHELQEKTMSTPGFG 1283

  Fly   298 MS-SHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISL-----GSKFYY---------------- 340
            .. ..||.:.||.:.          |||.:.. :::.:     |::.|:                
 Worm  1284 QDVDEKHREYLWTNL----------RPHMMYT-IHVGVRTLPPGARKYWPQEVVTITDPTGPPFV 1337

  Fly   341 --------SGRTELQ-------AVQE---------------------------------SKQRGR 357
                    ||....|       |.:|                                 :::|.:
 Worm  1338 DVPKLVDSSGTQPGQQMIRLTPATEEYGPISHYWIILVPANYSTEDVVNLDPIELEKATAEKRAQ 1402

  Fly   358 IHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHD 422
            :.:....||||:|...|..||             ..|:||:.|...|.|...|:.....|:|...
 Worm  1403 LARSLSVSPSKKLKRKASEVG-------------DDSQSASYHPKEKRARRATVPGAYVTARLSA 1454

  Fly   423 NKVTSKEADSMP-------------------------------------RKAWEQQ-------SD 443
            ::|..:..::.|                                     :.::||:       |.
 Worm  1455 DRVKQQYRNNQPFIVGDSQLYDGFTNYPLEHNLHYRLMMRAFAKNDVRTKDSFEQRAPMSEKLSR 1519

  Fly   444 EY-DIQLDVGFIEQCTRRFESASPSPMPPA-----------------------YSSGQH------ 478
            .| |..|...|..:...|..|...||...|                       .|:|:|      
 Worm  1520 MYSDSVLTEPFTIKSALRGASQKSSPWVGACIAFLVLFSIVGMLICWWLRCNKKSAGRHPRHGSI 1584

  Fly   479 SPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFN----------VKGGVDL-SLPVQVS 532
            :.:.|...|.:..|....|:...|.|    ::|.||...|          ::..:|| .||...|
 Worm  1585 TKVALTGNIMNGGGGIPGETSKLLST----SNEYGRQIMNPYEQMNGNHHMESSMDLYPLPTSHS 1645

  Fly   533 KVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLL 597
            :...:.|.....|.       |..||.::..:.|..|          ...||...:...|     
 Worm  1646 RSNGYAPVPVAIPS-------LPNNGNNMTTVSHPAV----------PIAELANHIERLR----- 1688

  Fly   598 LEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEAR 662
            :.....:|...||.|.|.|         ||..                     ..:.|:      
 Worm  1689 MNNNAGFQSEFESIETGQH---------FTWE---------------------HSSADM------ 1717

  Fly   663 KPANAPKNRYRDISPYDCTRVSLVNSLTG----DYINANYVN-MEIPGGAVNRYIATQGPLASTT 722
               |..||||.:::.||.:||.|.| :.|    ||||||||: .:.|    ..||||||||..|.
 Worm  1718 ---NKHKNRYANVAAYDHSRVVLSN-VEGYPGMDYINANYVDGYDKP----RSYIATQGPLPETF 1774

  Fly   723 TDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGE------ELQLAEGFSVRCLSEKPDETG 781
            :||||||.:|.|..:||||.:.|..|.||.||||..|.      |:.|.|...:          .
 Worm  1775 SDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHL----------A 1829

  Fly   782 SFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQ 844
            .:..|...||  .:.|.|.|.|:||.|||||.||..|..||.|.:||     :||          
 Worm  1830 HYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRV-----KTL---------- 1879

  Fly   845 VRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVL 909
                                        .|.|.               .|:|.||||||||||..
 Worm  1880 ----------------------------NPNDA---------------GPIISHCSAGIGRTGAF 1901

  Fly   910 ILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA 958
            |::|..|..:.....|.....|..:|.||:.|||...||.|:.:.:..|
 Worm  1902 IVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDA 1950

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604 35/193 (18%)
FERM_N 38..102 CDD:286467 12/55 (22%)
FERM_M 125..232 CDD:278785 19/114 (17%)
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010 17/94 (18%)
FA 333..369 CDD:285894 11/104 (11%)
PDZ_signaling 502..589 CDD:238492 20/97 (21%)
Y_phosphatase 666..955 CDD:278528 106/301 (35%)
PTPc 668..955 CDD:238006 105/299 (35%)
ptp-3NP_001263671.1 I-set 93..184 CDD:254352
Ig 106..185 CDD:299845
IG_like 201..287 CDD:214653
Ig 212..288 CDD:299845
IG_like 302..378 CDD:214653
Ig 309..377 CDD:299845
FN3 383..499 CDD:238020
FN3 507..600 CDD:238020
FN3 605..693 CDD:238020
FN3 700..813 CDD:238020
FN3 818..918 CDD:238020
FN3 923..1020 CDD:238020
FN3 1027..1116 CDD:238020
fn3 1125..1213 CDD:278470 21/109 (19%)
PTPc 1694..1949 CDD:214550 115/366 (31%)
PTPc 1720..1949 CDD:238006 105/301 (35%)
PTPc 1980..2239 CDD:214550
PTPc 2008..2239 CDD:238006
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.