DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptpmeg and DLG4

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:XP_011522001.1 Gene:DLG4 / 1742 HGNCID:2903 Length:797 Species:Homo sapiens


Alignment Length:633 Identity:126/633 - (19%)
Similarity:215/633 - (33%) Gaps:195/633 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   344 TELQAVQESKQRGRIHKVFV---RSPSKRLL-------------GAAGGVGTSGSSGGTPMQQHS 392
            |...||:..|:.|.|.:::|   :.|:::::             ..|||||.....|...:....
Human   202 THSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTK 266

  Fly   393 GSESANSHNNGKPAGAGTILTITKTSRP---HDNKVTSKEAD--------SMPRKAWEQQSDEY- 445
            ..|...:|.:|:......||.:......   |::.|.:.:..        :.|..|:  .||.| 
Human   267 IIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAY--LSDSYA 329

  Fly   446 --DIQLDVGFIEQCTRRFESAS------PSPMPPAYSSGQHSPILLPTTIADAVGHQQ-PESGSD 501
              ||  ...:.:........:|      |:.|.|. |..::||:     ..|.:|.:. |.....
Human   330 PPDI--TTSYSQHLDNEISHSSYLGTDYPTAMTPT-SPRRYSPV-----AKDLLGEEDIPREPRR 386

  Fly   502 LITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRH 566
            ::..|....    .|||:.||.| ...:.:|.::...||| .:..:.:||::|.:||.|:....|
Human   387 IVIHRGSTG----LGFNIVGGED-GEGIFISFILAGGPAD-LSGELRKGDQILSVNGVDLRNASH 445

  Fly   567 EQVV-------------------------AMIRDCRHQ------ASGELLLTVRPQRSAPLLLEE 600
            ||..                         |.|.|.|.|      .||...|...|:|...:    
Human   446 EQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYI---- 506

  Fly   601 EPLYQYVPESDEIGSHSNLLD---GDAL---------FTQSLLLLSD------------------ 635
            ..|:.| .::.:.|..|..|.   ||.|         :.|:..:.||                  
Human   507 RALFDY-DKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERR 570

  Fly   636 ----------GLASGA-----------LLAQYELMYRKNPDLAITEARKPAN------------- 666
                      |.:||:           .:.|.|:.|.: |.:.:...:..||             
Human   571 EWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYAR-PIIILGPTKDRANDDLLSEFPDKFGS 634

  Fly   667 ------APKNRYRDISPYDCTRVSLVNSLTGD-----YINANYVNMEIPGGAVN--RYIATQGP- 717
                  .||..| :|...|...||....:..|     :|.|...|..:.|.:|.  |.:|.||. 
Human   635 CVPHTTRPKREY-EIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKH 698

  Fly   718 -LASTTTDFWRMVQQESSHLLVM------LTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSE 775
             :...:.:..|.:|....|.:.:      |..|:|..::       :|.|:.:.|...:.:...|
Human   699 CILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKR-------ITEEQARKAFDRATKLEQE 756

  Fly   776 KPDETGSFVFREFVLKDKHEQRHIHH-----MQYLAWPDHCVPSDPNL 818
            ..:     .|...|..|..|:  |:|     ::.|:.|...||:...|
Human   757 FTE-----CFSAIVEGDSFEE--IYHKVKRVIEDLSGPYIWVPARERL 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604
FERM_N 38..102 CDD:286467
FERM_M 125..232 CDD:278785
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010
FA 333..369 CDD:285894 8/27 (30%)
PDZ_signaling 502..589 CDD:238492 28/117 (24%)
Y_phosphatase 666..955 CDD:278528 39/192 (20%)
PTPc 668..955 CDD:238006 38/171 (22%)
DLG4XP_011522001.1 L27 <26..49 CDD:413432
MAGUK_N_PEST 54..137 CDD:402306
PDZ 138..222 CDD:395476 6/19 (32%)
PDZ 233..317 CDD:395476 13/83 (16%)
PDZ_assoc 318..385 CDD:402299 17/76 (22%)
PDZ 383..467 CDD:214570 20/89 (22%)
SH3_DLG4 503..568 CDD:212963 11/69 (16%)
Guanylate_kin 606..784 CDD:395500 37/193 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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