DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and frm-1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_493601.2	Gene:	frm-1 / 173360	WormBaseID:	WBGene00001488	Length:	4648	Species:	Caenorhabditis elegans

Alignment Length:	1007	Identity:	231/1007 - (22%)
Similarity:	379/1007 - (37%)	Gaps:	208/1007 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DKKTP--------QRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQK 82
            |:|.|        .:.|...||..|.:...|.:.|.::|..|..||.:.|.:.||:||.|.|..|
Worm     9 DQKHPTTSQQPRDSKMQLAKVLLPDGVQKEFEVNKNSEGEALFRQVTRDLSIEEREYFSLCFYDK 73

  Fly    83 PGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLG 147
            ......|:...|...||...:..:      ..|.|||:.:.|:.:.::..||..:||::|::|.|
Worm    74 DEGTRHWLYNDKNIAKQIKGLPWE------FSFEVKFYPTTPTTIVDDHARYYVFLQLRRDLLTG 132

  Fly   148 KLPCSSNTQCLLASYTVQSELGDFNALEHQPGY-----LSGMQLLCDQTTEAERKVGELHKLHRG 207
            :||.:::|..||.|:..|.|.||..| |....|     .|.:........|..:|:.:||:..||
Worm   133 RLPATADTHSLLGSFVAQIEFGDAPA-EMTDAYEQFIVASKLVPSAQANPETYKKIVDLHREMRG 196

  Fly   208 QLPADAEYNYLEHAKRLELYGIDLHRA-TDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKV 271
            |.|::||..:|:|.|.|.||||.|.:| :|.:.|.:.:|:.|.|:.::|...:.::|||..::|:
Worm   197 QTPSEAENQFLDHCKHLALYGIHLFKAISDKDKKPVDVGIGAAGINIYQDEQKTHSFSWQNIIKI 261

  Fly   272 SFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGS 336
            .::|..|.|:|:....|..:..|.|.:.:|..||..||..||||:||||.:|...:.....:.||
Worm   262 GYRRTYFSIKLKAGTVEKNEKTLYFKLPNHVAAKRTWKCAVEHHTFFRLIQPEDKTHKSFFNFGS 326

  Fly   337 -KFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVG--------TSGSSGGTPMQQHS 392
             :|.|.|||:.|....|:...:...| .|:||......|....        |.........:::.
Worm   327 QRFRYQGRTQFQTKIASQMFDKPSTV-DRAPSAMSQPIATAENQKLQTLNLTDSELEQRQFERYR 390

  Fly   393 GSESANSHNNGK-PAGAGTILTITKTSRPHDNKV--TSKEADSMPRK-AWEQQSDEYDIQLDVGF 453
            .:.:..|:.:.: ...|.:..|..|.|||....|  ||......|.: ::..:.|:........:
Worm   391 RALTPKSYTSSRQDDDAVSTATFAKYSRPSTLLVVSTSGHHQQSPHELSYSPRGDDSSNYSSAAY 455

  Fly   454 I--EQCTRRFESAS-------PSPMPPAYSSGQH----SPILLPTTIADAVGHQQPESG------ 499
            .  |:.:.|..|::       .||..|.|..|||    ...:..|....|.|  ...||
Worm   456 YMSERSSLRTPSSAYYPPSEYTSPTSPVYFEGQHHGEYHVQMRQTASTSATG--PSNSGARRNLF 518

  Fly   500 ---SDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHT---------PA------------ 540
               ||..:.:...|......|:.        ||..::.:|:|         |.
Worm   519 GRASDARSSQASRDSVRLVSFHE--------PVDPNEPIPNTYPYSELPQIPIERIVHVYHEGHY 575

  Fly   541 DRCTPRVCEGDE-------------VLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQR 592
            ||.:||..:..|             |..::.....|...:|.:....|.||..:....|..|...
Worm   576 DRLSPRRQQRPELPYGFGNYTPRNGVSHVDNLQPDGEMDQQPIRFYVDVRHSGASRRNLAKRLSH 640

  Fly   593 SAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGL--------ASGALLAQYELM 649
            ..    :|:...|..|:             |..|:.|  |.||.:        ...|.:.||...
Worm   641 PG----KEDIKEQIDPK-------------DYYFSAS--LASDPIHRTELSREVQPANIQQYTRR 686

  Fly   650 YRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANY----------VNMEIP 704
            |.....:     .||..........:.|...|.....:..:...:||..          |..|.|
Worm   687 YHHGDSI-----HKPDTPQYRLITHVHPLAVTNRDGRDGQSSSNLNATISQREQVVSTKVRRESP 746

  Fly   705 --------GGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVME-SGR-QKCHQYWPVTG 759
                    ..:|:|    .|.|..||.:..|...:.::...|:.|.::| .|: :|.:|..|.:.
Worm   747 DADRRVRLSASVDR----SGNLTDTTEEMTRSTNEAATPTTVVTTRIVEKKGKGKKNNQKIPPSS 807

  Fly   760 EELQLAE-----------GF----SVRCLSEKPDETGSF------VFREFVLKDKHEQRHIHHMQ 803
            .:...|.           ||    :.:.||..|:.|..|      ..|:..|:...........|
Worm   808 NKTDHASFEGQEKRSRFGGFFTKKTSQTLSGYPESTSQFTGELDATHRDDDLEPSTFSHSNKSQQ 872

  Fly   804 YLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIE--ESLKQVRLM-----DADAD-------- 853
            |.:..|..:       :...|....:.|:..|..:|  |..|:.||:     :.|.|
Worm   873 YSSKQDKTI-------ITSVESKSDSGNKKRLMAVESPEVPKKYRLIARIRHEGDEDVVEKPEKY 930

  Fly   854 ---ADENGGLMRERKCAASNGATPEDETPVST 882
               .|.:.|::.|     :......|:.|:|:
Worm   931 SFVTDSHSGMLEE-----TYRQKELDQIPISS 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	65/201 (32%)
		FERM_N	38..102	CDD:286467	21/63 (33%)
		FERM_M	125..232	CDD:278785	39/111 (35%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	34/94 (36%)
		FA	333..369	CDD:285894	13/36 (36%)
		PDZ_signaling	502..589	CDD:238492	19/120 (16%)
		Y_phosphatase	666..955	CDD:278528	50/276 (18%)
		PTPc	668..955	CDD:238006	50/274 (18%)
frm-1	NP_493601.2	B41	27..221	CDD:214604	65/200 (33%)
		PH-like	216..310	CDD:388408	33/93 (35%)
		FA	321..357	CDD:370090	11/36 (31%)
		4_1_CTD	4542..4646	CDD:368659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910