DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and T22C1.8

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_492194.1	Gene:	T22C1.8 / 172571	WormBaseID:	WBGene00011918	Length:	591	Species:	Caenorhabditis elegans

Alignment Length:	443	Identity:	116/443 - (26%)
Similarity:	167/443 - (37%)	Gaps:	115/443 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 QVSKVVPHTPADRCTPRVCEGDE----VLMINGRDVHGLRHEQV------------VAMIRDCRH 578
            |.|:.:...|:|.   :|.|.|:    ||...|..:|..:.|:|            ....|.|.|
Worm    16 QASRRLAKKPSDE---KVDEKDKKKGGVLKRLGFLLHNEKKEEVGSTQKRRKPKRGTERKRACSH 77

  Fly   579 QASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALF-TQSLLLL---SDGLAS 639
            .       ...|.:.  :....|..:..:|           |.||.|. .|..:..   ||.:..
Worm    78 P-------VWNPDKK--IHFNNEKTHAIIP-----------LKGDPLSDVQKKVFFKFASDAVKK 122

  Fly   640 GALLAQYELMYRKNPDLAITEARK--PANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNME 702
            .......|.|.:..|.......||  .||..||||:|:...|.|||.|.:...||||:|||||
Worm   123 NPPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGDGDYIHANYVN-- 185

  Fly   703 IPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEG 767
               |....:|.|||..|:|..||||||....:..:|||..|||.|:.||.||:|....|......
Worm   186 ---GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGA 247

  Fly   768 FSVRCLSEKPDETGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR 830
            :::.| |.:.|:..:.:.|...::  |..::..:.|:...:|||.|||:.....|.....||
Worm   248 WTILC-SLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVR--- 308

  Fly   831 NRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPV 895
                                                                       .|:.||
Worm   309 -----------------------------------------------------------TASGPV 314

  Fly   896 IVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQY 948
            .|||||||||||..:.::..|.::...:.:..|...|.:|:.||..:|...||
Worm   315 TVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQY 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	16/74 (22%)
		Y_phosphatase	666..955	CDD:278528	84/285 (29%)
		PTPc	668..955	CDD:238006	83/283 (29%)
T22C1.8	NP_492194.1	PTPc	130..376	CDD:214550	90/306 (29%)
T22C1.8	NP_492194.1	PTPc	153..376	CDD:238006	83/283 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910