DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and frm-4

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001249887.1	Gene:	frm-4 / 172189	WormBaseID:	WBGene00001491	Length:	672	Species:	Caenorhabditis elegans

Alignment Length:	680	Identity:	157/680 - (23%)
Similarity:	258/680 - (37%)	Gaps:	143/680 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVD-- 91
            :|:..:|...|..|.........:......:||.|.|...:.|:|:.||.: |.......|:|
Worm    24 SPKDVRCNVHLLHDSDIIGNEFPRTQSAQTILDYVCQLKHIQEKDFLGLRY-QDHHKHRYWLDLT 87

  Fly    92 -----AQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPC 151
                 ..|.|||:...|.......  |..|.:::.|||:||::...|||.::|::|::|.|:|.|
Worm    88 RSINHVVKNFKKEIKKVGKTESMT--LHLRFRYYPSDPARLRDPNLRYQLFVQLQRDLLHGRLYC 150

  Fly   152 SSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEYN 216
            .:::...||:..:|::|||:|..:|...|:||.:||..||.:.|.::...||..:|:....||..
Worm   151 PTSSAAELAALILQAQLGDYNEEKHVGNYVSGYKLLLKQTPKLEERIANNHKELKGKSSESAELE 215

  Fly   217 YLEHAKRLELYGIDLHRATDSNGK-ELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFI 280
            :||.|.:|:.|..|.:...:.:.. .:.:|.|..|:|::....|.:...||::|||.:..|:..:
Worm   216 FLEKASQLDTYAFDPYTIKEPHDTLPVYIGASCKGILIYTGQSRTHNIDWSELVKVDYSGKEIRL 280

  Fly   281 QLRREPSENY-----------DTLLGFG---------------------MSSHKHAKALWKSCVE 313
            .|    ||||           .||.|.|                     ..|.:.||.||...:.
Worm   281 TL----SENYRGQITAAGTPTGTLNGHGPGSPSIMDKSLTKKPLTLKYTCPSGQFAKHLWIHILS 341

  Fly   314 HHSFFR------LKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLG 372
            ..:||.      :|......|...:|.||.|.:..:             |:::......||.:|.
Worm   342 QQAFFNETSAQDVKLKFSKPRIPLLSRGSTFRFPSK-------------RVYREIEEEDSKSILF 393

  Fly   373 AAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGT------ILTIT-------------KTS 418
            ....:.||.....|.....:.....|......|..:|:      :|..|             |.:
Worm   394 DKSIMETSAVMNETTTSNENEESILNCSTISAPLSSGSGVVRYDLLRQTPRVEQPWLKQNSLKVT 458

  Fly   419 RPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMP-PAYSSGQHS--- 479
            ..|||..:|..:...........|...::.|.:       .|..|.|||..| |...:.|||
Worm   459 TVHDNTASSSSSPDNSETQNNNLSKITNLNLSI-------EREVSTSPSTSPVPIVHTQQHSDHN 516

  Fly   480 ----PILL-----------PTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPV 529
                .:.|           .|:.....|.||          .|:.:..|:.......||||
Worm   517 STSFTVHLIKREEVATSSSSTSSTTTTGQQQ----------NLEKNGNGKLANGGGSGVDL---- 567

  Fly   530 QVSKVVPHTPADRCTPRVC---EGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQ 591
              .|...||..   |..:|   :.|.:|.::    ..|..:.:::.|.:........|||.|
Worm   568 --GKKTVHTNG---TTLICTEEKQDSILSMD----ESLTSKSLISRIANTCFVFFLILLLIV--- 620

  Fly   592 RSAPLLLEEEPLYQYVPESDEIGSHSNLLD 621
             :..::|.|:.  :....:|.|.||..|.|
Worm   621 -AIVIVLFEKS--EDSAHNDFIESHRALSD 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	62/203 (31%)
		FERM_N	38..102	CDD:286467	17/70 (24%)
		FERM_M	125..232	CDD:278785	38/106 (36%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	29/132 (22%)
		FA	333..369	CDD:285894	6/35 (17%)
		PDZ_signaling	502..589	CDD:238492	18/89 (20%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
frm-4	NP_001249887.1	B41	29..226	CDD:214604	60/199 (30%)
frm-4	NP_001249887.1	PH-like	212..346	CDD:388408	33/137 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910