DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and erm-1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_491560.1	Gene:	erm-1 / 172174	WormBaseID:	WBGene00001333	Length:	564	Species:	Caenorhabditis elegans

Alignment Length:	457	Identity:	115/457 - (25%)
Similarity:	194/457 - (42%)	Gaps:	95/457 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 FRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPL 112
            |.|:....|.:|.|||.:.:.|.|..||||.:....| ...|:    :..|:..|..:..|...:
Worm    20 FAIQSSTTGKQLFDQVVKTIGLREIWYFGLQYTDNKG-FPTWL----KLNKKVLSQDVKKDPTLV 79

  Fly   113 LEFRVKFFVSD-PSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEH 176
            .:||.||:..| ...:.::.|...||||:|..||..::.|...|..|||||.:|::.||:....|
Worm    80 FKFRAKFYPEDVAEEIIQDVTMRLFYLQVKDGILSDEIYCPPETSVLLASYAMQAKYGDYVPETH 144

  Fly   177 QPGYLSGMQLLCDQ--------TTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHR 233
            ..|.|:..:||..:        :.|.||::......||......|...||:.|:.||:||::...
Worm   145 VAGCLTADRLLPQRVLGQFKLNSEEWERRIMTWWADHRATTREQAMLEYLKIAQDLEMYGVNYFE 209

  Fly   234 ATDSNGKELQLGVSAVGLLVFQHSLRVNT---FSWSKMVKVSFKRKDFFIQLRREPSENYDTLLG 295
            ..:..|.:|.|||.|:||.::..:.|::.   |.||::..:||..|.|.|:...:.:.:: ....
Worm   210 IRNKKGTDLYLGVDALGLNIYDKADRLSPKVGFPWSEIRNISFNDKKFVIKPIDKKAHDF-VFYA 273

  Fly   296 FGMSSHKHAKALWKSCVEHHSFF------------RLKRPHRLSRFLNISLGSKFYYSGRTELQA 348
            ..:..:|...||   |:.:|..:            ::|:..|..|.|.|:...|.    ..|:.|
Worm   274 PRLRINKRILAL---CMGNHELYMRRRKPDTIEVQQMKQQAREDRALKIAEQEKL----TREMSA 331

  Fly   349 VQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQ---QHSGSESANSHNNGKPAGAGT 410
            .:|::||       .|...||:               ..||   :.:..|.|.:||
Worm   332 REEAEQR-------QRDAEKRM---------------AQMQEDMERARLELAEAHN--------- 365

  Fly   411 ILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSS 475
              ||      |..:...|:. .:.::|.||:  ||:::       :.|.:.:|..      |.|.
Worm   366 --TI------HSLEAQLKQL-QLAKQALEQK--EYELR-------ELTAQLQSEK------AMSD 406

  Fly   476 GQ 477
            |:
Worm   407 GE 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	59/192 (31%)
		FERM_N	38..102	CDD:286467	16/53 (30%)
		FERM_M	125..232	CDD:278785	36/114 (32%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	24/108 (22%)
		FA	333..369	CDD:285894	7/35 (20%)
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
erm-1	NP_491560.1	B41	9..208	CDD:214604	59/192 (31%)
		FERM_C_ERM	202..298	CDD:270015	24/99 (24%)
		Caldesmon	<302..>362	CDD:366885	17/85 (20%)
		ERM	333..564	CDD:366293	26/131 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910