Protein Alignment Ptpmeg and tln-1

DIOPT Version :9

• Sequence 1: NP_001163309.2
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: NP_490886.2
• Gene: tln-1 / 171736
• WormBaseID: WBGene00006771
• Length: 2553
• Species: Caenorhabditis elegans
• Alignment Length: 1059
• Identity: 202/1059 - (19%)
• Similarity: 332/1059 - (31%)
• Gaps: 329/1059 - (31%)

  Fly     2 FERFRLNN-----------LTRTFRLRGGGPELARDKKTPQRQQCVTV-------------LFLD 42
            ||.:.:.|           |.:...|.|....::.|:..|..|..:||             |..|
 Worm    69 FEHYLVRNKDEIEYKRKIRLLKVRMLDGAVKTISVDESQPVSQLMMTVCNKIGISNYEEYSLVRD 133

  Fly    43 DIT----------------HTFRIEK-------------------RAKGSELLDQVFQYLELSER 72
            ||.                .|:.:::                   |.|..:.|:::.:.|...|.
 Worm   134 DILMQNGGGGGGGGGQNGGSTWNLKEKESRSKSSDRGGGGIYGTMRKKNEQKLEELRKKLHTDEE 198

  Fly    73 DYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVS-------DPSRLQEE 130
                          :.|:|..|..::|    .:..:...:|  |.|:|.|       ||.:|.
 Worm   199 --------------LPWLDHTKTLREQ----GITEEETLIL--RRKYFFSDSNVDSRDPVQLN-- 241

  Fly   131 FTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQ---TT 192
                ..|:|.:..||.|..|....|...||:.....:.||| ..:....:|.|..:|..:   ..
 Worm   242 ----LLYVQCRDGILRGLHPVEKETAFQLAALQSHIQYGDF-PYDKPKFHLDGRDVLPKEYAKNK 301

  Fly   193 EAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHS 257
            |.|:||..::|...|....||:..|:...:.|:.||:
 Worm   302 ENEKKVVAMYKELSGTSELDAKSKYVHLCRGLKTYGV---------------------------- 338

  Fly   258 LRVNTFSWSKMVKVSFKRKDFFIQLRREPSEN--YDTLLGFGMSSHKHAKALWKSCVEHHSFFRL 320
                               .||:...:.|.:|  ...|||....|........|..::.....::
 Worm   339 -------------------TFFVVKEKLPGKNKLVPRLLGVNKESVMRVDENSKQILKEWPLEQV 384

  Fly   321 KRPHRLSRFLNISLG--SKFYYS-----GRTELQAVQE------SKQRGRIHKVF---------- 362
            :|....::..::..|  ...|||     |....|.:|.      .|:|.:.|:..
 Worm   385 RRWVPSAKCFSLDFGDYQDGYYSVQTTDGEKIAQLIQGYVDIILKKKRTQDHQGIEGDEGSTMLE 449

  Fly   363 -VRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPH----- 421
             :.:|:|..|.|.|.:|:.         ||:        .:|..|..|.:.|      |.
 Worm   450 DMVAPAKATLVAHGQIGSG---------QHA--------TDGLVAVRGVLRT------PQGGQGY 491

  Fly   422 ----------DNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSG 476
                      ..::||:|.....|..: |...::..:..:|.||...|..|.|.
 Worm   492 GINGAQYGAVSGEITSQELARAQRLRY-QDMYQHPQRALIGTIEATIRAVEDAE----------- 544

  Fly   477 QHSPILLPTTIADAVGHQQ---PESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHT 538
                       .:.....|   |....|....|...::|.....||...: .::....::||..|
 Worm   545 -----------IELEAEPQIDIPRFNDDYSQNRWMEEQQAVNKENVNERL-AAMGAATAQVVQWT 597

  Fly   539 PADRCTPRVCEGDEVLMI---------NGRDV-----HGLRHEQVVAMIRDCRHQASGELLLTVR 589
            ..:....||  |..:..|         |.||:     |..|.:.:.|..:.|  .|.|:.|.||.
 Worm   598 AVEEYDDRV--GTAIATIGSNLPDVSRNVRDLGAFMEHRERGDLLDATKKLC--GAFGKFLNTVN 658

  Fly   590 PQRSAPLLLEEEPLYQYVPESDEIGSH-SNLL----DGDALFTQSLLLLSDGLASGALLAQYELM 649
            |:..|    ....:::......|...| .|::    :|...|.:.|:..:..:|:..  ||..|.
 Worm   659 PETEA----RRNEVFRTAGHVGETSQHLINVMEAPNEGQQKFDERLVQSAKNVATST--AQLVLC 717

  Fly   650 YR---KNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVNRY 711
            .:   ...|....:.|...:|.|..:.......|.||      ....|:.|....::...|..
 Worm   718 AKTISAECDEPQVQERVIQSATKCAFATSQLVACARV------VAPTIDNNACQQQLSTAATE-- 774

  Fly   712 IATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQ------------KCHQYWPVTGEELQL 764
             .||. :.:...|....|.|:||     ||.:.|:.||            ||......|..|.:.
 Worm   775 -VTQS-VNNLLHDAEHAVYQQSS-----LTDIHEAARQVTSALDSLLEHAKCSPKTQTTRREEEE 832

  Fly   765 AEGFSVR-----CLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTE 824
            .....:|     .:.:.|.|..:...|:.|   :|.|......|:.|   |..|......|:...
 Worm   833 MYNEVLRRTNRMVVHQGPSEDLTREARKVV---RHSQLLTEQFQHEA---HQRPEHRERLLDAAA 891

  Fly   825 RVRAARNRTLL--QEIEESLKQVRLMDADADADENGG--------------LMRERKCAASNGAT 873
            :|..|.:..:|  ::.|...:||....|...|.|..|              :|:..:.||..  |
 Worm   892 KVAHATSEMILATEQAESQPRQVETEYALRTAAERLGQVTNETTQEQQEQHIMQRLEQAAKQ--T 954

  Fly   874 PEDETPVSTSVHQCISAAN 892
            ..|.|       |.|||||
 Worm   955 AYDAT-------QTISAAN 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	51/254 (20%)
		FERM_N	38..102	CDD:286467	15/111 (14%)
		FERM_M	125..232	CDD:278785	28/109 (26%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	11/95 (12%)
		FA	333..369	CDD:285894	11/59 (19%)
		PDZ_signaling	502..589	CDD:238492	22/100 (22%)
		Y_phosphatase	666..955	CDD:278528	58/260 (22%)
		PTPc	668..955	CDD:238006	57/258 (22%)
tln-1	NP_490886.2	FERM_f0	4..84	CDD:293120	3/14 (21%)
		B41	89..341	CDD:214604	56/325 (17%)
		FERM_N	91..>135	CDD:286467	9/43 (21%)
		FERM_M	232..341	CDD:278785	30/162 (19%)
		FERM_C_Talin	337..428	CDD:269973	18/137 (13%)
		Talin_middle	525..683	CDD:286254	36/188 (19%)
		I_LWEQ	698..>783	CDD:302998	17/96 (18%)
		talin-RS	1667..1839	CDD:213393
		VBS	1863..1984	CDD:286057
		talin-RS	1985..2146	CDD:213393
		ILWEQ	2357..2549	CDD:214607

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910