DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptpmeg and tln-1

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:NP_490886.2 Gene:tln-1 / 171736 WormBaseID:WBGene00006771 Length:2553 Species:Caenorhabditis elegans


Alignment Length:1059 Identity:202/1059 - (19%)
Similarity:332/1059 - (31%) Gaps:329/1059 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 FERFRLNN-----------LTRTFRLRGGGPELARDKKTPQRQQCVTV-------------LFLD 42
            ||.:.:.|           |.:...|.|....::.|:..|..|..:||             |..|
 Worm    69 FEHYLVRNKDEIEYKRKIRLLKVRMLDGAVKTISVDESQPVSQLMMTVCNKIGISNYEEYSLVRD 133

  Fly    43 DIT----------------HTFRIEK-------------------RAKGSELLDQVFQYLELSER 72
            ||.                .|:.:::                   |.|..:.|:::.:.|...|.
 Worm   134 DILMQNGGGGGGGGGQNGGSTWNLKEKESRSKSSDRGGGGIYGTMRKKNEQKLEELRKKLHTDEE 198

  Fly    73 DYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVS-------DPSRLQEE 130
                          :.|:|..|..::|    .:..:...:|  |.|:|.|       ||.:|.  
 Worm   199 --------------LPWLDHTKTLREQ----GITEEETLIL--RRKYFFSDSNVDSRDPVQLN-- 241

  Fly   131 FTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQ---TT 192
                ..|:|.:..||.|..|....|...||:.....:.||| ..:....:|.|..:|..:   ..
 Worm   242 ----LLYVQCRDGILRGLHPVEKETAFQLAALQSHIQYGDF-PYDKPKFHLDGRDVLPKEYAKNK 301

  Fly   193 EAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHS 257
            |.|:||..::|...|....||:..|:...:.|:.||:                            
 Worm   302 ENEKKVVAMYKELSGTSELDAKSKYVHLCRGLKTYGV---------------------------- 338

  Fly   258 LRVNTFSWSKMVKVSFKRKDFFIQLRREPSEN--YDTLLGFGMSSHKHAKALWKSCVEHHSFFRL 320
                               .||:...:.|.:|  ...|||....|........|..::.....::
 Worm   339 -------------------TFFVVKEKLPGKNKLVPRLLGVNKESVMRVDENSKQILKEWPLEQV 384

  Fly   321 KRPHRLSRFLNISLG--SKFYYS-----GRTELQAVQE------SKQRGRIHKVF---------- 362
            :|....::..::..|  ...|||     |....|.:|.      .|:|.:.|:..          
 Worm   385 RRWVPSAKCFSLDFGDYQDGYYSVQTTDGEKIAQLIQGYVDIILKKKRTQDHQGIEGDEGSTMLE 449

  Fly   363 -VRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPH----- 421
             :.:|:|..|.|.|.:|:.         ||:        .:|..|..|.:.|      |.     
 Worm   450 DMVAPAKATLVAHGQIGSG---------QHA--------TDGLVAVRGVLRT------PQGGQGY 491

  Fly   422 ----------DNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSG 476
                      ..::||:|.....|..: |...::..:..:|.||...|..|.|.           
 Worm   492 GINGAQYGAVSGEITSQELARAQRLRY-QDMYQHPQRALIGTIEATIRAVEDAE----------- 544

  Fly   477 QHSPILLPTTIADAVGHQQ---PESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHT 538
                       .:.....|   |....|....|...::|.....||...: .::....::||..|
 Worm   545 -----------IELEAEPQIDIPRFNDDYSQNRWMEEQQAVNKENVNERL-AAMGAATAQVVQWT 597

  Fly   539 PADRCTPRVCEGDEVLMI---------NGRDV-----HGLRHEQVVAMIRDCRHQASGELLLTVR 589
            ..:....||  |..:..|         |.||:     |..|.:.:.|..:.|  .|.|:.|.||.
 Worm   598 AVEEYDDRV--GTAIATIGSNLPDVSRNVRDLGAFMEHRERGDLLDATKKLC--GAFGKFLNTVN 658

  Fly   590 PQRSAPLLLEEEPLYQYVPESDEIGSH-SNLL----DGDALFTQSLLLLSDGLASGALLAQYELM 649
            |:..|    ....:::......|...| .|::    :|...|.:.|:..:..:|:..  ||..|.
 Worm   659 PETEA----RRNEVFRTAGHVGETSQHLINVMEAPNEGQQKFDERLVQSAKNVATST--AQLVLC 717

  Fly   650 YR---KNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVNRY 711
            .:   ...|....:.|...:|.|..:.......|.||      ....|:.|....::...|..  
 Worm   718 AKTISAECDEPQVQERVIQSATKCAFATSQLVACARV------VAPTIDNNACQQQLSTAATE-- 774

  Fly   712 IATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQ------------KCHQYWPVTGEELQL 764
             .||. :.:...|....|.|:||     ||.:.|:.||            ||......|..|.:.
 Worm   775 -VTQS-VNNLLHDAEHAVYQQSS-----LTDIHEAARQVTSALDSLLEHAKCSPKTQTTRREEEE 832

  Fly   765 AEGFSVR-----CLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTE 824
            .....:|     .:.:.|.|..:...|:.|   :|.|......|:.|   |..|......|:...
 Worm   833 MYNEVLRRTNRMVVHQGPSEDLTREARKVV---RHSQLLTEQFQHEA---HQRPEHRERLLDAAA 891

  Fly   825 RVRAARNRTLL--QEIEESLKQVRLMDADADADENGG--------------LMRERKCAASNGAT 873
            :|..|.:..:|  ::.|...:||....|...|.|..|              :|:..:.||..  |
 Worm   892 KVAHATSEMILATEQAESQPRQVETEYALRTAAERLGQVTNETTQEQQEQHIMQRLEQAAKQ--T 954

  Fly   874 PEDETPVSTSVHQCISAAN 892
            ..|.|       |.|||||
 Worm   955 AYDAT-------QTISAAN 966

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604 51/254 (20%)
FERM_N 38..102 CDD:286467 15/111 (14%)
FERM_M 125..232 CDD:278785 28/109 (26%)
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010 11/95 (12%)
FA 333..369 CDD:285894 11/59 (19%)
PDZ_signaling 502..589 CDD:238492 22/100 (22%)
Y_phosphatase 666..955 CDD:278528 58/260 (22%)
PTPc 668..955 CDD:238006 57/258 (22%)
tln-1NP_490886.2 FERM_f0 4..84 CDD:293120 3/14 (21%)
B41 89..341 CDD:214604 56/325 (17%)
FERM_N 91..>135 CDD:286467 9/43 (21%)
FERM_M 232..341 CDD:278785 30/162 (19%)
FERM_C_Talin 337..428 CDD:269973 18/137 (13%)
Talin_middle 525..683 CDD:286254 36/188 (19%)
I_LWEQ 698..>783 CDD:302998 17/96 (18%)
talin-RS 1667..1839 CDD:213393
VBS 1863..1984 CDD:286057
talin-RS 1985..2146 CDD:213393
ILWEQ 2357..2549 CDD:214607
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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