DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptpmeg and FRMPD2

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:NP_001018081.4 Gene:FRMPD2 / 143162 HGNCID:28572 Length:1309 Species:Homo sapiens


Alignment Length:1096 Identity:222/1096 - (20%)
Similarity:363/1096 - (33%) Gaps:384/1096 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 RQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQ- 95
            |..||.:|....:.....:|...  ..:.:.|..:..|.|..||||.: .|..:.. ::|::.: 
Human   342 RDLCVVLLNGQHLEVKCDVESTV--GAVFNAVTSFANLEELTYFGLAY-MKSKEFF-FLDSETRL 402

  Fly    96 -------FKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSS 153
                   :::|....|::...   |..|:|||||....||...||:|||||::::||..:|.|:.
Human   403 CKIAPEGWREQPQKTSMNTFT---LFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNE 464

  Fly   154 NTQCLLASYTVQSELGDF--NALEHQP-----GYLSGMQLLCDQTTEAERKVGELHKLHRGQLPA 211
            .....|....:|:|.|::  ..:|.:|     .|:....:........:.:|.|:|:|.......
Human   465 EILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGE 529

  Fly   212 DAEYNYLEHAKRLELYGIDLHRATDSNGK---ELQLGVSAVGLLVFQ----HSLRVNTFSWSKMV 269
            |||..:|...::|..||:.:|:......:   |:.||:.|.|::|::    ..:.:..|.|.:..
Human   530 DAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETG 594

  Fly   270 KVSFKRKDFFIQLRREPSENYDTLLG----FGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFL 330
            |:|..:|.|.|.         .::.|    |...|.|.:|.|...|...|.|             
Human   595 KISTYQKKFTIT---------SSVTGKKHTFVTDSAKTSKYLLDLCSAQHGF------------- 637

  Fly   331 NISLGS-----------KFYYSGRTELQAVQESKQRGRI---------HKVFVRSPSKRLLGAAG 375
            |..:||           ||..  ...|....:::.:..|         :::||    .||.||||
Human   638 NAQMGSGQPSHVLFDHDKFVQ--MANLSPAHQARSKPLIWIQRLSCSENELFV----SRLQGAAG 696

  Fly   376 ---------------------GVGTSGSSG--------------------GTPMQ-QHSGSES-- 396
                                 |:|.|..:|                    |.|:| .|:||::  
Human   697 GLLSTSMDNFNVDGSKEAGAEGIGRSPCTGREQLKSACVIQKPMTWDSLSGPPVQSMHAGSKNNR 761

  Fly   397 ------------------ANSH-------NNGKPAG-------------------------AGTI 411
                              .:.|       |.|:.:|                         .|.|
Human   762 RKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQI 826

  Fly   412 LTITKTS---------------------------------RPHDNK-------VTSKEADSMPRK 436
            |.:...|                                 .|.:.|       |:|.:..|...:
Human   827 LALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQ 891

  Fly   437 ----AWEQQSDEYDIQLDVGFIEQCTRRF-ESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQP 496
                :..|..|....:||:..::....|. ...|..|:..|.||...||               |
Human   892 GSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSP---------------P 941

  Fly   497 E-SGSDLITIRLQADEQGRYGFNVKGGVDLSLP---VQVSKVVPHTPADRCTPRVCEGDEVLMIN 557
            | |..::..:.| ..|.|..||:|.||::.|:|   :.|..:||..||.: ..::.:||.:|.::
Human   942 EISAGEIYFVEL-VKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAK-EGQILQGDRLLQVD 1004

  Fly   558 GRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNLLDG 622
            |..:.||.|:|.|..:              ..|.:.|.|:||..     ||.|.:....:|...|
Human  1005 GVILCGLTHKQAVQCL--------------TGPGQVARLVLERR-----VPRSTQQCPSANDSMG 1050

  Fly   623 DALFTQSLLLLSDGLASGALLA----QYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRV 683
            |.....||:....|..|..:..    ::|:..:||           ||.....:..:....|:. 
Human  1051 DERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKN-----------ANGLGFSFVQMEKESCSH- 1103

  Fly   684 SLVNSLTGDYINANYV--------NMEIPGG----AVNRYIATQGPLASTTTDFWRMVQQESSHL 736
                 |..|.:....:        |..|..|    |||.. :|:|           ::.||..||
Human  1104 -----LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGR-STEG-----------LIFQEVLHL 1151

  Fly   737 L--------VMLTTVMESGRQKCHQYWPVTGEELQLAEGF-----SVRCLSEKPDETGSFVFREF 788
            |        ::|.........:..|.|..  .||...:.|     :..|.|...|:..|      
Human  1152 LRGAPQEVTLLLCRPPPGALPELEQEWQT--PELSADKEFTRATCTDSCTSPILDQEDS------ 1208

  Fly   789 VLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADAD 853
                              |.|...|.               ....|....|.|.|.:|       
Human  1209 ------------------WRDSASPD---------------AGEGLGLRPESSQKAIR------- 1233

  Fly   854 ADENGGLMRERKCAASNGATPE------------DETPVSTSVHQ-----CISAAN 892
             :...|..|||..|:|...:||            ||:.::||:.:     |.|..:
Human  1234 -EAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 1288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604 53/211 (25%)
FERM_N 38..102 CDD:286467 12/71 (17%)
FERM_M 125..232 CDD:278785 31/113 (27%)
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010 25/104 (24%)
FA 333..369 CDD:285894 8/55 (15%)
PDZ_signaling 502..589 CDD:238492 24/89 (27%)
Y_phosphatase 666..955 CDD:278528 49/269 (18%)
PTPc 668..955 CDD:238006 48/267 (18%)
FRMPD2NP_001018081.4 KIND 15..197 CDD:214801
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 214..249
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..302
B41 346..550 CDD:214604 52/210 (25%)
FERM_C_PTPH13 546..647 CDD:270008 27/122 (22%)
PDZ_signaling 773..857 CDD:238492 8/83 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 859..880 2/20 (10%)
PDZ 947..1034 CDD:214570 29/102 (28%)
PDZ 1078..1167 CDD:214570 22/117 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1204..1228 7/62 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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